A systematic review on marine umami peptides: Biological sources, preparation methods, structure-umami relationship, mechanism of action and biological activities

Food Bioscience, Journal Year: 2024, Volume and Issue: 57, P. 103637 - 103637

Published: Jan. 17, 2024

Language: Английский

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Immunomodulatory peptides from thick-shelled mussel (Mytilus coruscus): Isolation, identification, molecular docking and immunomodulatory effects on RAW264.7 cells

Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 103874 - 103874

Published: March 8, 2024

Language: Английский

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Systematical Investigation on Anti-Fatigue Function and Underlying Mechanism of High Fischer Ratio Oligopeptides from Antarctic Krill on Exercise-Induced Fatigue in Mice

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(7), P. 322 - 322

Published: July 19, 2024

High Fischer ratio oligopeptides (HFOs) have a variety of biological activities, but their mechanisms action for anti-fatigue are less systematically studied at present. This study aimed to evaluate the efficacy HFOs from Antarctic krill (HFOs-AK) and explore its mechanism through establishing fatigue model endurance swimming in mice. Therefore, according comparison with group, HFOs-AK were able dose-dependently prolong time, reduce levels metabolites (lactic acid, blood urea nitrogen, ammonia), increase content glucose, muscle glycogen, liver lactate dehydrogenase creatine kinase extravasation, protect tissue damage shown enhance Na+-K+-ATPase Ca2+-Mg2+-ATPase activities ATP tissue. Meanwhile, also showed significantly antioxidant ability by increasing superoxide dismutase glutathione peroxidase decreasing level malondialdehyde. Further studies that could regulate body’s energy metabolism thus exert effects activating AMPK signaling pathway up-regulating expression p-AMPK PGC-α proteins. can be used as an auxiliary functional dietary molecules good activity applied foods.

Language: Английский

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Optimization of the Preparation Process and Ameliorative Efficacy in Osteoporotic Rats of Peptide–Calcium Chelates from Skipjack Tuna (Katsuwonus pelamis) Meat

Foods, Journal Year: 2024, Volume and Issue: 13(17), P. 2778 - 2778

Published: Aug. 30, 2024

This study aimed to establish the preparation process of peptide–calcium chelates (TMP-Ca) using skipjack tuna meat and investigate function mechanism TMP-Ca in an osteoporosis model rats. The results indicated that trypsin is more suitable for preparing Ca-chelating hydrolysates meat, optimal hydrolysis conditions were derived as follows: digestion time 4 h, material–liquid ratio 1:10, enzyme dose 3%. chelating Ca with hydrolysate optimized be chelation 50 min, temperature °C, pH 8.0, a peptide–Ca 1:10. prepared was subjected ultrafiltration, fraction (TMP) (MW <1 kDa) showed highest rate (51.27 ± 1.42%) made into (TMP-Ca). In osteoporotic rats, significantly improved decrease ovarian indexes caused by retinoic acid. It also elevated serum Ca, phosphorus, bone turnover indexes, increased number trabeculae, microstructure. addition, we confirmed could regulate OPG/TRAF6 pathway reduce osteoclast differentiation, inhibit resorption, promote formation. Therefore, ameliorate osteoporosis, this provides functional component healthcare products treat osteoporosis.

Language: Английский

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High Fischer ratio oligopeptides from Antarctic krill: Ameliorating function and mechanism to alcoholic liver injury through regulating AMPK/Nrf2/IκBα pathways

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106537 - 106537

Published: Oct. 25, 2024

Language: Английский

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Recent advances in the use of antarctic krill (Euphausia superba) as a sustainable source of high-quality protein: A comprehensive review

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 152, P. 104684 - 104684

Published: Aug. 31, 2024

Language: Английский

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Bioactive peptides of marine organisms: Roles in the reduction and control of cardiovascular diseases

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(8), P. 5271 - 5284

Published: April 23, 2024

Cardiovascular diseases (CVDs) affect the quality of life or are fatal in worst cases, resulting a significant economic and social burden. Therefore, there is an urgent need to invent functional products drugs for improving patient health alleviating controlling these diseases. Marine bioactive peptides reduce control CVDs. Many predisposing factors triggering CVDs can be alleviated by consuming foods containing marine biopeptides. CVD incidence through use effective biopeptide from sources has attracted increasing interest attention. This review reports information on derived various organisms, focusing process separation, purification, identification biological peptides, characteristics, food promoting cardiovascular health. Increasing evidence shows that bioactivity safety significantly impact their storage, processing. It feasible develop further strategies involving treat testing methods. Future work should focus producing high-quality applying them drug industry.

Language: Английский

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Comprehensive characterization of bioactive peptides in rice bran protein hydrolysates: A multi‐platform approach for metabolomic profiling, identification, and molecular docking analysis

Cereal Chemistry, Journal Year: 2024, Volume and Issue: 101(5), P. 1000 - 1019

Published: June 6, 2024

Abstract Background and Objectives To optimize the utilization of rice by‐products, bran protein hydrolysate (RBPH) was subjected to a process separation purification using ultrafiltration reversed‐phase high‐performance liquid chromatography (RP‐HPLC). Subsequently, identification peptide sequences carried out mass spectrometer hybrid quadrupole‐time‐of‐flight nontargeted metabolomic profiling done UHPLC‐QTOF‐IMS identify antioxidant antihypertensive amino acids. Findings Three novel bioactive peptides, namely, STCCK, FMKSK, KICILVFTLTTC, were identified within RBPH through enzymatic digestion alcalase, pepsin, trypsin. These peptides showed significant activity angiotensin‐converting enzyme (ACE) inhibitory activity. Molecular docking analyses elucidated various interaction mechanisms between these ACE receptor protein, including hydrogen bonding hydrophobic interactions. This suggested that effectively suppress by forming bonds with active pockets human high affinity. Conclusion In summary, derived from exhibited distinguished properties, underscoring their potential for valuable in addressing by‐products. Significance Novelty The study advances scientific knowledge offers practical solutions health improvement sustainable agriculture.

Language: Английский

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Structural, antioxidant activity, and stability studies of jellyfish collagen peptide–calcium chelates

Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101706 - 101706

Published: July 31, 2024

Language: Английский

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Polysaccharides extracted from larvae of Lucilia sericata ameliorated ulcerative colitis by regulating the intestinal barrier and gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132441 - 132441

Published: May 16, 2024

Language: Английский

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