Synthetic antimicrobial Nkl and Dic peptides are immunomodulatory but only Dic peptide can be therapeutic against nodavirus infection DOI Creative Commons
Laura Cervera, Marta Arizcún, Luís Mercado

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 152, P. 109772 - 109772

Published: July 16, 2024

Aquaculture is a prosperous economic sector threatened by viral infections. Among the viruses threatening fish culture, Betanodavirus (NNV) extremely important in Mediterranean Sea affecting to highly traded species as European sea bass. In this context, application of antimicrobial peptides (AMPs) has arisen potential biotechnological tool. The aim work was evaluate therapeutic two bass-derived AMPs, NK-lysin (Nkl) and dicentracin (Dic), against NNV Synthetic Dic peptide able significantly reduce NNV-induced mortalities while Nkl failed do so. Although neither nor were alter transcriptional levels number infected cells, seemed increase load per cell. Interestingly, both showed immunomodulatory roles. For instance, our data revealed an interplay among different at gene protein levels. Otherwise, provoked anti-inflammatory balance upon infection, well recruitment macrophages B cells target site brain. conclusion, can be proposed candidate combat NNV.

Language: Английский

Synthetic antimicrobial Nkl and Dic peptides are immunomodulatory but only Dic peptide can be therapeutic against nodavirus infection DOI Creative Commons
Laura Cervera, Marta Arizcún, Luís Mercado

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 152, P. 109772 - 109772

Published: July 16, 2024

Aquaculture is a prosperous economic sector threatened by viral infections. Among the viruses threatening fish culture, Betanodavirus (NNV) extremely important in Mediterranean Sea affecting to highly traded species as European sea bass. In this context, application of antimicrobial peptides (AMPs) has arisen potential biotechnological tool. The aim work was evaluate therapeutic two bass-derived AMPs, NK-lysin (Nkl) and dicentracin (Dic), against NNV Synthetic Dic peptide able significantly reduce NNV-induced mortalities while Nkl failed do so. Although neither nor were alter transcriptional levels number infected cells, seemed increase load per cell. Interestingly, both showed immunomodulatory roles. For instance, our data revealed an interplay among different at gene protein levels. Otherwise, provoked anti-inflammatory balance upon infection, well recruitment macrophages B cells target site brain. conclusion, can be proposed candidate combat NNV.

Language: Английский

Citations

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