Antifouling activity exhibited by pyrrolo compound isolated from marine sponge associated bacterium Halobacillus kuroshimensis SNSAB01 against barnacles DOI

S. Nalini,

S. Venkatnarayanan,

D. Inbakandan

et al.

International Biodeterioration & Biodegradation, Journal Year: 2024, Volume and Issue: 197, P. 105960 - 105960

Published: Nov. 29, 2024

Language: Английский

Latrunculin U: a potent actin-disrupter from the Red Sea marine sponge Negombata magnifica DOI
Diaa T. A. Youssef,

Mohamed M. AlOmmary,

Bushra M. Bashanfar

et al.

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 26, 2025

During our efforts to identify biologically active compounds from Red Sea marine invertebrates, a new compound, latrunculin U (1), was identified the sponge Negombata magnifica along with latrunculins A (2), B (3), and 16-epi-latrunculin (4). The structures of were elucidated based on combination comprehensive 1D 2D NMR analyses high-resolution mass spectral determinations. antiproliferative potency each compound in HeLa cells evaluated, they had IC50 values ranging 0.31 1.64 μM. activities indicated that 16-membered macrocyclic lactone moiety (1 2) more potent than those 14-membered (3 4), suggesting importance size macrolide for optimal activity. All four promoted disruption actin cytoskeleton cells, consistent reported actin-disrupting effects this class.

Language: Английский

Citations

0
Novel Anticancer Drug Discovery Strategies Targeting Hypoxia-Inducible factors DOI
Muhamad Mustafa, Mahmoud Rashed, Jean‐Yves Winum

et al.

Expert Opinion on Drug Discovery, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Hypoxia is a key feature of solid tumors, associated with aggressive behaviors such as radiation and chemotherapy resistance, increased metastasis, poor prognosis. Hypoxia-inducible factors (HIFs) are essential transcription that help tumor cells adapt to hypoxic environments by promoting the expression pro-oncogenic genes. Reducing HIF activity presents promising strategy for advancing cancer treatment.

Language: Английский

Citations

2
Harnessing Natural Inhibitors of Protein Synthesis for Cancer Therapy: A Comprehensive Review DOI Creative Commons
Liqin Liu, Zhihui Li, Wenshuang Wu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107449 - 107449

Published: Oct. 4, 2024

Cancer treatment remains a formidable challenge in modern medicine, necessitating nuanced understanding of its molecular underpinnings and the identification novel therapeutic modalities. Among intricate web cellular pathways implicated oncogenesis, protein synthesis has emerged as fundamental process warranting meticulous investigation. This review elucidates multifaceted role tumor initiation progression, highlighting potential targeting key nodes within these viable strategies. Natural products have long served source bioactive compounds with owing to their structural diversity evolutionary honing. Within this framework, we provide thorough examination natural inhibitors promising candidates for cancer therapy, drawing upon recent advancements mechanistic insights. By synthesizing current evidence elucidating challenges opportunities, aims galvanize further research into development product-based anticancer therapeutics, thereby advancing clinical armamentarium against malignancies.

Language: Английский

Citations

0
Antifouling activity exhibited by pyrrolo compound isolated from marine sponge associated bacterium Halobacillus kuroshimensis SNSAB01 against barnacles DOI

S. Nalini,

S. Venkatnarayanan,

D. Inbakandan

et al.

International Biodeterioration & Biodegradation, Journal Year: 2024, Volume and Issue: 197, P. 105960 - 105960

Published: Nov. 29, 2024

Language: Английский

Citations

0