Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules DOI Creative Commons

Changyu Liu,

Jiaxun Li, Dexu Wang

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(12), P. 540 - 540

Published: Nov. 30, 2024

Marine natural products are increasingly utilized in nutrition, cosmetics, and medicine, garnering significant attention from researchers globally. With the expansion of marine resource exploration recent years, demand for has risen, necessitating rapid cost-effective activity evaluations using model organisms. Zebrafish, a valuable vertebrate model, become an efficient tool screening identifying safe, active molecules products. This review, based on nearly 10 years literature, summarizes current status progress zebrafish models evaluating product bioactivity. It also highlights their potential exploring resources with health benefits, offering reference future development utilization biological resources.

Language: Английский

The intervention of macrophages in progressive fibrosis characterizing systemic sclerosis: A systematic review DOI Creative Commons
Rosanna Campitiello, Stefano Soldano, Emanuele Gotelli

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(10), P. 103637 - 103637

Published: Sept. 8, 2024

Language: Английский

Citations

4
Marine Phytoplankton Bioactive Lipids and Their Perspectives in Clinical Inflammation DOI Creative Commons
Edoardo Andrea Cutolo, Rosanna Campitiello, Valeria Di Dato

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 86 - 86

Published: Feb. 17, 2025

Marine phytoplankton is an emerging source of immunomodulatory bioactive lipids (BLs). Under physiological growth conditions and upon stress challenges, several eukaryotic microalgal species accumulate lipid metabolites that resemble the precursors animal mediators inflammation: eicosanoids prostaglandins. Therefore, marine could serve as a biotechnological platform to produce functional BLs with therapeutic applications in management chronic inflammatory diseases other clinical conditions. However, be commercially competitive, lipidic precursor yields should enhanced. Beside tailoring cultivation native producers, genetic engineering feasible strategy accrue production introduce heterologous biosynthetic pathways hosts. Here, we present state-of-the-art research on from discuss synthetic biology approaches boost their light-driven biosynthesis.

Language: Английский

Citations

0
Talaroterpenoids A–F: Six New Seco-Terpenoids from the Marine-Derived Fungus Talaromyces aurantiacus DOI Creative Commons

Zhongli Peng,

Hui Jia,

Yan-Liang Luo

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(10), P. 475 - 475

Published: Oct. 18, 2024

Six new highly oxidized seco-terpenoids, including three 3-nor-labdane type diterpenes, talaroterpenoids A–C (1–3), and meroterpenoids containing an orthoester group, D–F (6–8), together with five known compounds (4–5 9–11), were isolated from the marine-derived fungus Talaromyces aurantiacus. Their chemical structures elucidated through 1D, 2D NMR, HRESIMS, J-based configuration analysis (JBCA), computational ECD calculations, single-crystal X-ray diffraction analysis. Compounds 1 2 contain unusual 6,20-γ-lactone-bridged scaffold. 10 11 presented inhibitory effects on NO release in lipopolysaccharide (LPS)-induced BV-2 cells IC50 values of 11.47 11.32 μM, respectively. Talaroterpenoid C (3) showed moderate antifungal activity against A. alternata P. theae Steyaert.

Language: Английский

Citations

1
Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules DOI Creative Commons

Changyu Liu,

Jiaxun Li, Dexu Wang

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(12), P. 540 - 540

Published: Nov. 30, 2024

Marine natural products are increasingly utilized in nutrition, cosmetics, and medicine, garnering significant attention from researchers globally. With the expansion of marine resource exploration recent years, demand for has risen, necessitating rapid cost-effective activity evaluations using model organisms. Zebrafish, a valuable vertebrate model, become an efficient tool screening identifying safe, active molecules products. This review, based on nearly 10 years literature, summarizes current status progress zebrafish models evaluating product bioactivity. It also highlights their potential exploring resources with health benefits, offering reference future development utilization biological resources.

Language: Английский

Citations

0