Semisynthesis and biological evaluation of 17-hydroxybrevianamide N derivatives as anti-inflammatory agents by mediating NF-κB and MAPK signaling pathways
Tian-Yi Zhou,
No information about this author
Yangyang Guo,
No information about this author
Qian-Qian Jing
No information about this author
et al.
European Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 117541 - 117541
Published: March 1, 2025
Language: Английский
Antibacterial and antibiofilm effects of invasive corals Tubastraea coccinea and Tubastraea tagusensis
Academia Biology,
Journal Year:
2025,
Volume and Issue:
3(2)
Published: April 16, 2025
This
study
evaluated
the
antibacterial
and
antibiofilm
activities
of
methanolic
extracts
from
invasive
corals
Tubastraea
coccinea
tagusensis
a
synthesized
alkaloid
(APL01).
The
activity
was
by
macrodilution
microdilution
methods
using
16
bacterial
strains.
in
Staphylococcus
aureus
biofilm
inhibition
assay.
cytotoxic
potential
also
analyzed
human
carcinoma
cell
lines
HEp-2
Caco-2.
All
samples
were
capable
interfering
with
growth
strains,
highlighted
extract
T.
coccinea,
which
inhibited
Streptococcus
pyogenes
(8668)
strain
(IC50
=
66.31
µg
mL−1).
able
to
inhibit
formation,
EC50
values
for
EbMTc,
EbMTt,
APL01
being
414.1,
82.08,
153.9
mL−1.
Both
showed
effects;
Caco-2
line
most
sensitive.
results
expressed
as
selectivity
index.
(EbMTc
respectively)
presented
antimicrobial
potential,
inhibiting
S.
strain.
formation
biofilms
aureus.
EbMTc
promising
sample
activity.
use
sun
coral
pharmacological
research
can
be
studied
further.
Language: Английский
Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 28, 2025
In
recent
years,
medicinal
plants
have
gained
significant
attention
in
modern
medicine
due
to
their
accessibility,
affordability,
widespread
acceptance,
and
safety,
making
herbal
remedies
highly
valued
globally.
Consequently,
ensuring
plants’
quality,
efficacy,
safety
has
become
a
critical
concern
for
developed
developing
nations.
The
emergence
of
multidrug-resistant
microorganisms
poses
serious
global
health
threat,
particularly
low-income
regions,
despite
advancements
antimicrobial
drugs
medical
research
over
the
past
century.
rapid
spread
these
infections
is
primarily
attributed
improper
prescriptions,
overuse,
unregulated
access
antibiotics.
Addressing
challenges,
standardization
plant-derived
pharmaceuticals
could
pave
way
transformative
era
healthcare.
Preserving
leveraging
historical
knowledge
essential
before
such
valuable
information
lost.
Recently,
there
been
growing
interest
among
natural
pharmaceutical
scientists
exploring
as
potential
sources
agents.
This
current
review
aims
identify
most
common
pathogens
threatening
human
health,
analyze
factors
contributing
rise
drug-resistant
microorganisms,
evaluate
use
across
various
countries
alternative
antibiotics,
highlighting
unique
mechanisms
resistance.
Language: Английский
Anthoteibinenes A–E from the Irish Deep-Sea Coral Anthothela grandiflora: An Amination Puzzle
Stine S. H. Olsen,
No information about this author
Sam Afoullouss,
No information about this author
Ryan Young
No information about this author
et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 3, 2024
Chemical
investigation
of
extracts
from
the
Irish
deep-sea
soft
coral
Anthothela
grandiflora
revealed
cadinene-like
sesquiterpenes,
anthoteibinenes
A–E,
bearing
unusual
dimethylamine
substitution.
Structure
elucidation
was
accomplished
using
1D/2D
NMR
spectroscopy
and
high-resolution
mass
spectrometry,
while
NOESY
experiments,
gauge
invariant
atomic
orbital
(GIAO)
calculations
coupled
with
DP4+
probabilities
measures,
ECD
comparisons
were
incorporated
to
propose
their
relative
absolute
configurations.
Anthoteibinene
B
(2)
exhibited
49%
inhibition
respiratory
syncytial
virus
(RSV)
at
3.1
μM
no
cytotoxicity.
Language: Английский
A review on anti-inflammatory and antioxidant peptides derived from marine organisms: Mechanism of action and therapeutic applications
Kannan Thilothamai Jegani,
No information about this author
Akshad Balde,
No information about this author
Rasool Abdul Nazeer
No information about this author
et al.
Food Bioscience,
Journal Year:
2024,
Volume and Issue:
unknown, P. 105745 - 105745
Published: Dec. 1, 2024
Language: Английский
Diversity and antibacterial potential produced by marine endophytic fungi by submerged fermentation from Buton Island, Indonesia
BIO Web of Conferences,
Journal Year:
2024,
Volume and Issue:
147, P. 01007 - 01007
Published: Jan. 1, 2024
This
study
investigated
the
diversity
and
antibacterial
potential
of
marine
endophytic
fungi
from
Buton
Island,
Indonesia.
focused
on
identifying
capable
producing
bioactive
compounds
effective
against
Vibrio
harveyi
.
32
fungal
isolates
were
obtained
various
samples.
Aspergillus
terreus
(WB
1-2)
exhibited
highest
activity.
The
growth
dynamics
these
analyzed,
emphasizing
importance
log
phase
for
secondary
metabolite
production.
Environmental
conditions
mechanical
agitation
found
to
significantly
influence
yield.
These
findings
highlight
as
sources
novel
antimicrobial
agents,
suggesting
promising
opportunities
biotechnological
pharmaceutical
advancements.
underscores
untapped
development
new
antibiotics.
Language: Английский