Protective effect of deinoxanthin in sorafenib-induced nephrotoxicity in rats with the hepatocellular carcinoma model DOI

Nilgun Karasu,

Mehmet Kuzucu, Özge Cengiz Mat

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Language: Английский

Exploring the Metabolic Profiling and Anticancer Activities of Red Sea Sponges Echinodictyum asperum and Callyspongia siphonella against Human Breast Cancer Cells: A Comparative Study DOI Creative Commons
Samah S. Abuzahrah, Tahani Bakhsh, Reham Hassan Mekky

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(9), P. 9402 - 9425

Published: Feb. 25, 2025

Marine sponges are noteworthy sources of bioactive secondary metabolites that demonstrate fundamental functions in defense mechanisms and ecological interactions. This study focused on the extraction characterization from two sponge species, Echinodictyum asperum Callyspongia siphonella, obtained Red Sea coast Saudi Arabia. Methanol generated EAE CSE extracts, which were subjected to metabolic profiling, illuminating 44 identified involving fatty acids, sterols, terpenoids, long-chain amides, alkaloids. The cytotoxic effects both assessed versus MDA-MB-231 MCF-7 breast cancer cell lines, utilizing sulforhodamine B (SRB) assay, with IC50 values about 2.7 μg/mL for 0.5 cells 8.7 45.3 cells. Flow cytometry analysis indicated extracts induced apoptosis necrosis across lines. Particularly, G2 phase arrest cells, while elevated S population As well, boosted autophagy especially Comparative analyses existing literature underscore therapeutic potential these sponge-derived medication. Molecular docking studies demonstrated robust binding affinities between selected key targets MCL-1, BCL-2, ERα. In conclusion, this research emphasizes significant features proposing their purposes treatment via distinct action.

Language: Английский

Citations

0
Metabolic profiling and antioxidant activity of fenugreek seeds cultivars ‘Giza 2’ and ‘Giza 30’ compared to other geographically-related seeds DOI Creative Commons
Reham Hassan Mekky, Essam Abdel‐Sattar,

Maha-Hamadien Abdulla

et al.

Food Chemistry X, Journal Year: 2024, Volume and Issue: 24, P. 101819 - 101819

Published: Sept. 7, 2024

Language: Английский

Citations

3
Ginkgo biloba Extract Safety: Insights from a Real-world Pharmacovigilance Study of FDA Adverse Event Reporting System (FAERS) Events DOI

Yinhui Yao,

Jingyi Zhao, Li‐Qun Chen

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119010 - 119010

Published: Oct. 1, 2024

Language: Английский

Citations

2
Total alkaloids in Fritillaria cirrhosa D. Don alleviate OVA-induced allergic asthma by inhibiting M2 macrophage polarization DOI
Yu Wang,

Meihao Peng,

Xin Yang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118935 - 118935

Published: Oct. 11, 2024

Language: Английский

Citations

2
Patients with non‑small cell lung cancer with the exon 21 L858R mutation: From distinct mechanisms to epidermal growth factor receptor tyrosine kinase inhibitor treatments (Review) DOI Open Access
Jiayu Liu, Shouzheng Wang,

Han-Qi Yuan

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 29(3)

Published: Dec. 20, 2024

The most common oncogenic driver in non‑small cell lung cancer (NSCLC) is epidermal growth factor receptor (EGFR) gene mutations, which are more Asian (30‑50%) than Caucasian (10‑15%) populations. Exon 19 deletion (ex19del) and exon 21 L858R (ex21 L858R) mutations account for ~45 40% of all EGFR respectively. Moreover, EGFR‑tyrosine kinase inhibitors (TKIs) may be effective improve the quality life patients with NSCLC chemotherapy regimens. By contrast, ex21 mutation have a lower sensitivity duration response to EGFR‑TKIs as well shorter survival compared those ex19del mutation. However, current guidelines classify same condition recommend treatment strategy both. Aiming precision medicine, present review introduces compares different assess personalized options population this

Language: Английский

Citations

2
Study on the activity and mechanism of herbal formula anti-infection powder (AIP) against influenza-virus-induced pneumonia through genetic susceptibility genes DOI
Wenwen Feng,

Yueyao Zhang,

Yujia Wu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118959 - 118959

Published: Oct. 1, 2024

Language: Английский

Citations

0
Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms DOI

P. Snega Priya,

Raghul Murugan,

R Srileka

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 197, P. 107086 - 107086

Published: Oct. 28, 2024

Language: Английский

Citations

0
Protective effect of deinoxanthin in sorafenib-induced nephrotoxicity in rats with the hepatocellular carcinoma model DOI

Nilgun Karasu,

Mehmet Kuzucu, Özge Cengiz Mat

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Language: Английский

Citations

0