Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi Penicillium spp.: Chemical Diversity and Biological Activity DOI Creative Commons

Guojun Zhou,

Jin Cai, Bin Wang

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 23(1), P. 7 - 7

Published: Dec. 26, 2024

Mangrove ecosystems have attracted widespread attention because of their high salinity, muddy or sandy soil, and low pH, as well being partly anoxic periodically soaked by tides. plants, sediment-derived fungi, especially the Penicillium species, possess unique metabolic pathways to produce secondary metabolites with novel structures potent biological activities. This paper reviews structural diversity activity isolated from mangrove ecosystem-derived species over past 5 years (January 2020-October 2024), 417 natural products (including 170 new compounds, among which 32 compounds were separated under guidance molecular networking OSMAC approach) are described. The divided into six major categories, including alkaloids, polyketides, terpenoids, benzene derivatives, steroids, other classes. Among these products, plausible biosynthetic 37 also proposed; 11 skeleton structures, 26 contain halogen atoms. A total 126 showed activities, such cytotoxic, antifungal, antibacterial, anti-inflammatory, α-glucosidase-inhibitory exhibited diverse These bioactivities will continue guide separation synthesis structurally biologically active offer leading for development innovation pharmaceuticals pesticides.

Language: Английский

Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived Streptomyces sp. HDN150000 DOI Creative Commons
Xiaoting Zhang, Falei Zhang, Wenxue Wang

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(5), P. 188 - 188

Published: April 27, 2025

Three new structures named naphpyrone I–K (1–3) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from marine-derived Streptomyces sp. HDN155000. Their chemical structures, including configurations, elucidated by extensive NMR, MS, single-crystal X-ray diffraction, theoretical NMR calculations, DP4+ probability analysis, ECD analyses. Naphpyrone K (3) showed cytotoxic activities against L-02, K562, NCI-H446/EP, MDA-MB-231, NCI-H446 cancer cells with IC50 values of 5.13, 3.34, 2.50, 2.61, 2.20 μM, respectively. These findings highlight the potential for screening developing therapeutic drugs aromatic polyketides derived marine actinobacteria.

Language: Английский

Citations

0
Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi Penicillium spp.: Chemical Diversity and Biological Activity DOI Creative Commons

Guojun Zhou,

Jin Cai, Bin Wang

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 23(1), P. 7 - 7

Published: Dec. 26, 2024

Mangrove ecosystems have attracted widespread attention because of their high salinity, muddy or sandy soil, and low pH, as well being partly anoxic periodically soaked by tides. plants, sediment-derived fungi, especially the Penicillium species, possess unique metabolic pathways to produce secondary metabolites with novel structures potent biological activities. This paper reviews structural diversity activity isolated from mangrove ecosystem-derived species over past 5 years (January 2020-October 2024), 417 natural products (including 170 new compounds, among which 32 compounds were separated under guidance molecular networking OSMAC approach) are described. The divided into six major categories, including alkaloids, polyketides, terpenoids, benzene derivatives, steroids, other classes. Among these products, plausible biosynthetic 37 also proposed; 11 skeleton structures, 26 contain halogen atoms. A total 126 showed activities, such cytotoxic, antifungal, antibacterial, anti-inflammatory, α-glucosidase-inhibitory exhibited diverse These bioactivities will continue guide separation synthesis structurally biologically active offer leading for development innovation pharmaceuticals pesticides.

Language: Английский

Citations

0