Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1395 - 1395

Published: April 21, 2025

Conjugated linoleic acid (CLA) is a bioactive compound known for its anti-inflammatory, anti-carcinogenic, and metabolic effects, with growing interest in role supporting bone health. Preclinical studies, particularly those involving the t10c12 isomer, have shown that CLA can enhance mineral density (BMD) by enhancing formation reducing resorption, indicating potential as therapeutic agent to improve However, clinical trials yielded inconsistent results, underscoring difficulty translating animal model successes human applications. A major challenge CLA’s low water solubility, poor absorption, limited bioavailability, which restrict effectiveness. To address these issues, nanoparticle-based delivery systems been proposed stability, resistance oxidative damage, thereby bioactivity. Recent studies also suggest electrical stimulation stimulate regeneration promoting cell proliferation, differentiation, adherence scaffolds. This review explores combined use of supplementation novel approach improving health, osteoporosis management. By integrating biological effects regenerative stimulation, this multimodal strategy offers promising method restoration, significant implications applications

Language: Английский