PANoptosis in autoimmune diseases interplay between apoptosis, necrosis, and pyroptosis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 31, 2024

PANoptosis is a newly identified inflammatory programmed cell death (PCD) that involves the interplay of apoptosis, necrosis, and pyroptosis. However, its overall biological effects cannot be attributed to any one type PCD alone. regulated by signaling cascade triggered recognition pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs) various sensors. This triggers assembly PANoptosome, which integrates key components from other pathways via adapters ultimately activates downstream execution molecules, resulting in with necrotic, apoptotic, pyroptotic features. Autoimmune diseases are characterized reduced immune tolerance self-antigens, leading abnormal responses, often accompanied systemic chronic inflammation. Consequently, PANoptosis, as unique innate immune-inflammatory pathway, has significant pathophysiological relevance inflammation autoimmunity. most previous research on focused tumors infectious diseases, leaving activation role autoimmune unclear. review briefly outlines characteristics summarizes several PANoptosome complexes, their mechanisms, components. We also explored dual potential therapeutic approaches targeting PANoptosis. Additionally, we existing evidence for explore regulatory mechanisms involved.

Language: Английский

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A Review of the Impact of Sjögren’s Syndrome and/or the Presence of Anti-Ro/SS-A Antibodies on Therapeutic Strategies for Rheumatoid Arthritis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 568 - 568

Published: Jan. 17, 2025

Rheumatoid arthritis (RA) is an immune-mediated disease characterized by polyarthritis that affects the small joints of bilateral upper and lower extremities. RA shares several common clinical symptoms with Sjögren’s syndrome (SS), another rheumatic caused lymphocytic infiltration exocrine glands, dry eye mouth being two most symptoms. Anti-Ro/SS-A antibodies, a diagnostic biomarker SS, are positive in patients at certain rate. The coexistence SS and/or positivity for anti-Ro/SS-A antibodies influences activity effectiveness classes disease-modifying antirheumatic drugs (DMARDs). Furthermore, RA, DMARDs, including methotrexate, associated onset lymphoproliferative disorders (LPD). In contrast, biological such as tocilizumab rituximab, plausible options without risk LPD relapse. Considering results studies introduced this article, could be considered phenotype different from isolated perspective refractoriness to DMARD therapy risk. Hence, rheumatologists should observe caution when choosing DMARDs. Further needed establish appropriate treatment presence antibodies.

Language: Английский

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Disclosing the impact of metformin and methotrexate in adjuvant arthritis in female rats: molecular docking and biochemical insights on visfatin

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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Current understanding of the immunological basis of rheumatoid arthritis: from post-translational modification of proteins to the use of disease-modifying antirheumatic drugs

Eastern Ukrainian Medical Journal, Journal Year: 2023, Volume and Issue: 11(4), P. 326 - 336

Published: Jan. 1, 2023

Background. Rheumatoid arthritis (RA) is a multietiological chronic systemic autoimmune disease associated with inflammatory joint damage and extra-articular processes in internal organs. RA recognized as the most common an incidence of 0.4% to 1.3% population. Objective. Summarize current information on immunopathogenesis based data from open sources information. Methods. The selection publications that covered about rheumatoid was performed using following keywords: diseases, RA, citrullination, carbamylation. Results. considered immune-mediated strong genetic influence. An important role initiation development played by factors mucous membranes lungs, oral cavity, gastrointestinal tract.. In response appearance post-translationally modified (citrullinated/carbamylated) proteins, B-cells induce production antibodies cyclic citrullinated peptide (anti-citrullinated – ACPA). factor another well-studied autoantibody involved RA. Given complex dendritic cells play pathogenesis targeted therapies are being developed block their immunogenic or enhance tolerogenic functions. Dysfunction fibroblast-like synoviocytes leads synovial hyperplasia. Disease-modifying antirheumatic drugs (DMARDs) used target inflammation prevent progression. Conclusions. Genetic predisposition specific post-translational modifications proteins significant introduction DMARDs prospects for use mesenchymal stem derivatives allows new effective treatment strategies implement more control over this disease.

Language: Английский

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Secondary Metabolites, Anti-Diabetic, Antioxidant, Anti-Arthritic and Antimicrobial Potential of Justicia secunda for Health Benefits

Journal of Clinical Microbiology and Biochemical Technology, Journal Year: 2024, Volume and Issue: 10(1), P. 009 - 021

Published: Aug. 8, 2024

The study was designed to investigate the ameliorative effect of phytochemicals in extract Justicia secunda (JS) on hyperglycaemia, antioxidant status alloxan-induced diabetic rats, and inhibitory potential two important diabetes mellitus-associated proteins-alpha-amylase alpha-glucosidase. At same time evaluate anti-arthritic antibacterial sample. at doses 200 mg/kg 400 used hyperglycaemia antioxidants using albino rats model. There a significant decrease (p < 0.05) blood insulin concentration levels observed control group relative normal control, while treated groups showed relatively levels. A increase glucose control. reversal elevated upon treatment with JS when compared 0.01) Malondialdehyde (MDA) all test group. Glutathione (GSH) status, S-transferase (GST) catalase activities groups, It that 3,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one, 3-amino-4-methoxybutyric acid are inhibitors alpha-amylase 1-(1-adamantyl)-3-(dimethylamino)-1-propanone, 2-(2-hydroxypropyl)-1,4-benzenediol, Interestingly, were shown be stable dual inhibitor both α-amylase α-glucosidase. Anti-arthritic values ranged between 24.50-80.00%. Zone inhibition assay 0.7-30.0 mm. Galvinoxyl DPPH IC50 50.0 µgml-1 each. results this leaf possesses significantly reduce ameliorate oxidative stress evidenced rats. This plant may therefore serve as an excellent alternative therapy for management mellitus, arthritic bacterial-related health problems formulated food or drug supplement.

Language: Английский

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