Relationship of Thyroid Volume and Function with Carotid and Femoral Intima-Media Thickness in Euthyroid People Aged 18–65 Taking into Account the Impact of Diabetes, Hypertension, and Excess Body Mass

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 604 - 604

Published: Jan. 18, 2025

Background/Objectives: The interrelationship of thyroid volume and function with features cardiovascular dysfunction has already been investigated but some aspects remain unclear, especially in terms subclinical euthyroid patients. Intima-media thickness (IMT) measurement ultrasound B-mode imaging different vascular beds (most frequently within the common carotid artery) is one most important tools for detection atherosclerosis both clinical practice research. This article aimed to present results our research on association between evaluation parameters IMT measured femoral arteries patients aged 18 65 years taking into account influence diabetes, hypertension, excess body mass. Methods: We performed a retrospective cross-sectional analysis data from no disease who during planned hospitalization underwent ultrasound, determination biochemical function, Doppler carotid, vertebral, lower extremities measurement. Data 45 people (females: 57.8%) were analyzed. Results: No significant correlations found parameters. Thyroid was be significantly correlated all superficial artery (R = 0.407, p 0.007 mean calculated left side right side) minimal taken 0.342, 0.025). Selected shown higher arterial obesity, or metabolic syndrome comparison without mentioned comorbidities. Using multiple linear regression, it confirmed that related status do not affect value. A effect diabetes and, lesser extent, hypertension value confirmed, arteries. Conclusions: In population patients, correlates IMT.

Language: Английский

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The Effect of Thyroid Lobe Volume on the Common Carotid Artery Blood Flow in Thyroidectomy Position

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1743 - 1743

Published: March 5, 2025

Background/Objectives: This study investigates the effect of thyroid lobe size on common carotid artery hemodynamics during thyroidectomy. While prior research has reported reduced blood flow procedure, impact remains unclear. We hypothesized that larger lobes may influence dynamics via external compression. Methods: Adult patients undergoing elective thyroidectomy were prospectively included. Doppler ultrasonography measured diameters and characteristics at three time points: before anesthesia induction, after surgical positioning. Regional cerebral oximetry was recorded. Each analyzed separately. Results: Data from 202 arteries (132 patients) analyzed. Baseline velocities similar between with normal large lobes. Anesthesia induction in all patients. After positioning, had significantly increased peak systolic velocity, leading to an overestimation flow, when using formula-based calculations. Manually traced Velocity Time Integral confirmed increase velocity a shortened systolic/diastolic ratio these Receiver operating characteristic analysis identified volume cutoff 19.7 mL (AUC: 0.93, Sensitivity: 85%, Specificity: 98%). oxygen saturation remained unchanged (p > 0.05). Conclusions: Larger are associated altered thyroidectomy, emphasizing diastolic flow. findings provide insight into thyroid-related hemodynamic changes, their applicability pre-existing stenosis or peripheral disease uncertain, as our population did not include such cases.

Language: Английский

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Association of gender and metabolic factors with thyroid nodules in T2DM: a retrospective study

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19068 - e19068

Published: March 26, 2025

Sex differences in the incidence of thyroid nodules (TNs) are broadly recognized, but further analysis is lacking. Thus, aim this study was to evaluate association between TNs and anthropometric parameters type 2 diabetic males females. This cross-sectional included 747 patients with diabetes mellitus (T2DM). All underwent clinical examination, ultrasound, laboratory tests, anthropometrics body composition. Multivariable logistic regression assessed factors associated TNs, a simple nomogram finally developed. In total, 36.95% (276/747) significantly higher females (52.75%) than (27.85%). Age positively correlated risk T2DM (males: OR = 4.141, 95% CI [1.999-8.577], females: 4.630, [1.845-11.618]). Obesity (OR 2.655, [1.257-5.607]) hyperuricemia 1.997, [1.030-3.873]) were only independent other females, as well obesity such weight, BMI, waist-hip ratio, percent fat, visceral curve area, upper arm circumference, not males. However, diameter largest nodule related age (R 0.226, p < 0.01). Finally, for evaluating female established, C-index 0.704 (95% [0.89-0.94]). occur frequency males, especially those obesity. Modifiable metabolic factors, hyperuricemia, major focus improving women.

Language: Английский

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Analysis of Tryptophan Metabolic Profile Characteristics and Clinical Value in Differentiated Thyroid Cancer Patients

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(6)

Published: March 1, 2025

ABSTRACT Background Differentiated thyroid cancer (DTC) is the primary subtype of cancer. Timely diagnosis and intervention are crucial for improving prognosis survival. However, effectiveness existing serum markers limited, necessitating discovery new biomarkers. Methods This study utilized liquid chromatography–tandem mass spectrometry to analyze tryptophan metabolic profiles in samples from 105 DTC patients 50 healthy controls. Independent predictors were identified through univariate intergroup comparisons multivariate logistic regression analysis, leading development validation a diagnostic model. Results Significant differences observed 11 metabolites between Logistic nicotinamide, 3‐hydroxyanthranilic acid, 5‐hydroxytryptophan, melatonin, indole‐3‐propionic acid as independent predictors. The nomogram prediction model was established based on these five metabolites, according Hosmer–Lemeshow test, showed good fit. five‐metabolite demonstrated 84.8% sensitivity, 90.0% specificity, an area under ROC curve 0.932. Decision analysis indicated that had significant advantages over thyroglobulin. Discussion Tryptophan metabolism exhibits distinct changes patients, with specific serving early markers. panel demonstrates potential detection management DTC.

Language: Английский

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The Association of Thyroid Disease with Risk of Dementia and Cognitive Impairment: A Systematic Review

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1917 - 1917

Published: Nov. 21, 2024

Background and Objectives: Cognitive impairment is defined as a reduced ability to perform one or more cognitive functions, potentially leading dementia if the condition worsens. With being rapidly growing public health issue affecting approximately 50 million people worldwide, understanding modifiable risk factors such thyroid disease crucial for prevention early diagnosis. Thyroid hormones play vital role in brain development functioning, impacting processes neuron growth, myelination, neurotransmitter synthesis. Recent decades have seen disorders emerging potential independent reversible impairment. Materials Methods: The review adheres PRISMA guidelines, utilizing structured PICO question explore whether individuals with diseases higher of developing impairments compared those without. literature search was conducted PubMed, Cochrane, ScienceDirect databases, including studies published from 1 January 2019 31 December 2023. discusses nine selected articles. Results: findings highlight complex association between dysfunction decline, some indicating significant links, particularly hypothyroidism, others suggesting relationship may depend on specific type domain affected. Six out articles found link impairment, while three refuted this link. Conclusions: reveals ambiguous Further research needed elucidate mechanisms underlying these associations determine be factor dementia.

Language: Английский

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