The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts DOI Creative Commons
Nazario Carrabba, Mattia Alexis Amico,

Gherardo Busi

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 20, 2025

Abstract Aims Valvular heart disease (VHD) is the third leading cause of cardiovascular morbidity, with its incidence and public health impact projected to increase significantly. This study adopts a novel perspective, focusing on elderly individuals residing in rural areas, highlighting unique dynamics small-town settings. Methods multicenter, observational was conducted from May 2022 September 2023, under coordination AOU Careggi Echo Core-Lab, which managed entire screening program. In 10 small Italian villages, each municipality facilitated enrollment asymptomatic aged ≥ 65 years, no prior VHD history, through voluntary participation. Participants were grouped into three age categories (65–69, 70–74, 75 years) underwent thorough evaluation, including Quality Life (QoL) questionnaire comprehensive echocardiographic assessment detection grading. Results Among 1,113 participants, prevalence severity showed significant ( p < 0.0001). Remarkably, 94% years had at least one valvular defect, 22.5% presenting moderate or severe valvulopathy, 4.8% for aortic valve stenosis 7.5% mitral regurgitation. Right-sided valvulopathies followed similar trend, affecting 71.9% participants. QoL evaluations revealed generally positive perceived status, mean score 77 ± 16. Conclusions Our registry highlights that over living communities substantial, increases age, predominantly degenerative etiology. Notably, most undiagnosed themselves as healthy.

Language: Английский

Full‐Field Assessment of Geometry and Collagenous Architecture of Porcine Valve Leaflets via Laser Micrometry and Quantitative Polarized Light Imaging DOI Creative Commons
S. Sreedhar, Daniel Pearce, Colleen M. Witzenburg

et al.

Journal of Biophotonics, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Despite the frequent failure of aortic valves and pediatric usage pulmonary as a replacement, comparative studies on their full-field collagenous architecture macroscale geometries are limited. We applied laser micrometry quantitative polarized light imaging (QPLI), novel technique for assessing collagen fiber organization, to porcine (n = 8) valve leaflets non-destructively compare thickness anisotropy. confirmed (1) intensity sample inversely related (2) thicker with decreased organization when unloaded. To demonstrate ability QPLI capture dynamic alignment, we imaged during equibiaxial loading. There was an increase in leaflet's degree alignment throughout loading, whereas leaflet exhibited relatively unchanged alignment. Ultimately, understanding heterogeneous ECM how it is altered by pathology can inform therapy development.

Language: Английский

Citations

0
Assessment of the risk of atrial fibrillation after mitral valve re- construction using various types of support rings up to 12 months after operation DOI Creative Commons
Д. И. Лебедев, I. V. Dvadtsatov, А. В. Евтушенко

et al.

Journal of Arrhythmology, Journal Year: 2025, Volume and Issue: 32(1), P. 32 - 37

Published: March 8, 2025

Aim . To evaluate the effect of mitral valve (MV) reconstruction using rigid and superelastic support rings for up to one year in patients with regurgitation (MR) II according A. Carpentier on development atrial fibrillation (AF). Methods The study included 62 indications surgical correction MR sinus rhythm (SR): group I (n=31) - implantation biological semi-rigid saddle closed ring NeoRing open RIGID. average age was 56.6±11.2 years 58.0±10.2 groups II. Both were comparable gender (men 67.7% 61.3%), age, comorbidity, functional class chronic heart failure NYHA. assessed by Holter monitoring at control points after 9 days 12 months. Results duration artificial circulation, aortic occlusion, incidence isolated P2-segment prolapse did not differ comparison groups. A positive reverse remodeling left revealed: end-diastolic dimension ventricle (p<0.001), atrium a decrease overload pulmonary circulation pressure artery (p<0.001). According data, all had SR. showed satisfactory result hospital stage form restoration locking function MV (p<0.001) low frequency revealed maximum grade 1 9.7% 29% (p=0.292). However, RIGID higher values transvalvular diastolic gradient flow velocity (p < 0.001). In II, Pcp 3.34±1.01 mm Hg, versus 2.39±0.62 Hg 0.001), Vcp 79±15 cm/sec 66±12 I, respectively After months, more often change from SR AF 11 cases (35.5%), 4 (12.9%). echocardiography data freedom ≥ 2 93.5%, 77.4% (p=0.076). addition, maintained 3.70 [3.00; 4.40] mmHg, 2.3 [2.05; 2.85] mmHg as well 79 [71; 94] 70 [64; 79] (p=0.017). developed months surgery those whose exceeded 2.7 grade. Conclusions medium term, ring, an increased transmitral is cause AF, while accompanied high risk developing within (p=0.029).

Language: Английский

Citations

0
Evaluation of the Timing to Noncardiac Surgery following Cardiac Operations: A National Analysis DOI Creative Commons

Saad Mallick,

Shayan Ebrahimian,

Sara Sakowitz

et al.

JACC Advances, Journal Year: 2025, Volume and Issue: 4(4), P. 101668 - 101668

Published: March 19, 2025

Despite advancements in peri-operative care and conflicting evidence regarding the need for preoperative coronary revascularization, optimal timing of noncardiac surgery (NCS) following cardiac operations remains unclear. The purpose this study was to evaluate effect time interval between NCS on risk major adverse events (MAEs). Adults undergoing elective CABG, valve repair or replacement, combined procedures were identified 2016 2020 Nationwide Readmissions Database, with subsequent admission analyzed. index modeled using restricted cubic splines, clinical outcome differences evaluated across various urgency categories. Of 1,335,175 patients surgery, 20,253 (1.5%) required a NCS. On risk-adjusted examination MAE rates as function delay after an inflection point noted at 100 days postoperatively. Based threshold, 47.9% who had within considered early while others grouped late. Late associated significantly lower odds (adjusted OR: 0.69; 95% CI: 0.62-0.76), in-hospital mortality 0.66; 0.46-0.96), compared This relationship persisted all surgical subgroups whether elective. Additionally, nonelective classically categorized low general population, exhibited comparable high-risk When feasible, delaying NCS, particularly beyond days, appears be reduction events, suggesting potential opportunity optimization patient outcomes.

Language: Английский

Citations

0
Épidémiologie des valvulopathies en France DOI
Clémence Grave, A. Gabet,

C Tribouilloy

et al.

Archives des Maladies du Coeur et des Vaisseaux - Pratique, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Citations

0
The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts DOI Creative Commons
Nazario Carrabba, Mattia Alexis Amico,

Gherardo Busi

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: March 20, 2025

Abstract Aims Valvular heart disease (VHD) is the third leading cause of cardiovascular morbidity, with its incidence and public health impact projected to increase significantly. This study adopts a novel perspective, focusing on elderly individuals residing in rural areas, highlighting unique dynamics small-town settings. Methods multicenter, observational was conducted from May 2022 September 2023, under coordination AOU Careggi Echo Core-Lab, which managed entire screening program. In 10 small Italian villages, each municipality facilitated enrollment asymptomatic aged ≥ 65 years, no prior VHD history, through voluntary participation. Participants were grouped into three age categories (65–69, 70–74, 75 years) underwent thorough evaluation, including Quality Life (QoL) questionnaire comprehensive echocardiographic assessment detection grading. Results Among 1,113 participants, prevalence severity showed significant ( p < 0.0001). Remarkably, 94% years had at least one valvular defect, 22.5% presenting moderate or severe valvulopathy, 4.8% for aortic valve stenosis 7.5% mitral regurgitation. Right-sided valvulopathies followed similar trend, affecting 71.9% participants. QoL evaluations revealed generally positive perceived status, mean score 77 ± 16. Conclusions Our registry highlights that over living communities substantial, increases age, predominantly degenerative etiology. Notably, most undiagnosed themselves as healthy.

Language: Английский

Citations

0