Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches

GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 5267 - 5286

Published: April 26, 2024

Abstract The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced medical community to phenomenon of long COVID, a condition characterized persistent symptoms following resolution acute phase infection. Among myriad reported COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond initial viral pathology. Emerging evidence pointed mitochondrial dysfunction as potential underpinning mechanism contributing persistence diversity symptoms. This review aims synthesize current findings related in exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic endothelial dysfunction. Through comprehensive analysis literature, we highlight significance health pathophysiology drawing parallels with similar clinical syndromes linked post-infectious states other diseases where impairment been implicated. We discuss therapeutic strategies targeting function, including pharmacological interventions, lifestyle modifications, exercise, dietary approaches, emphasize need further research collaborative efforts advance our understanding management COVID. underscores critical role calls multidisciplinary approach address gaps knowledge treatment options those affected this condition.

Language: Английский

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Management of cognitive impairment associated with post-COVID-19 syndrome: recommendations for primary care

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 22, 2024

Introduction: Although post-COVID-19 syndrome (PCS) with cognitive impairment is increasingly encountered in primary care, evidence-based recommendations for its appropriate management are lacking. Methods: A systematic literature search evaluating the diagnosis and treatment of associated PCS was conducted. Practical PCS-associated care summarized, based on an evaluation pharmacological plausibility clinical applications. Results: Currently, pathology remains unclear no high-quality data to support targeted interventions. Existing approaches directed towards symptom relief where counseling chronicity disease regular reassessments at 4- 8-week intervals considered reasonable. Patients should be informed encouraged adopt a healthy lifestyle that centers around balanced nutrition physical activities. They may also benefit from intake vitamins, micronutrients, probiotics. The administration Ginkgo biloba extract could offer safe potentially beneficial option. Other non-pharmacological measures include physiotherapy, digitally supported training, and, if indicated, ergotherapy or speech therapy. In most patients, symptoms improve within 8 weeks. If serious, ambiguous, when new occur, specialized diagnostic such as comprehensive neurocognitive testing neuroimaging initiated. Very few patients would require inpatient rehabilitation. Conclusion: debilitating condition affect daily functioning reduce work productivity. Management multidisciplinary approach, centering physical, cognitive, therapies.

Language: Английский

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The Effect of Dietary Supplementation on Physical Performance in Adolescent Male Soccer Players Infected with SARS-CoV-2

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 527 - 527

Published: Jan. 31, 2025

The impact of the COVID-19 infection on athletes was reported to influence physical health, both decreasing performance and increasing risk injuries. This study aimed assess (maximal aerobic power, muscle function, speed) a group male adolescent soccer players before after compare effects nutrition intervention performance. included 99 players, between 13 15 years old, that had mild SARS-CoV-2 infection. Their evaluated in three periods (1 month 1 3 months infection). subjects were divided into two groups, one with rigorous without. Physical through five tests: hand grip strength, 10 m sprint test, 30 beep bench press. A total 20.2% restrictions at spirometry One infection, four tests (hand test) showed statistically significantly (p < 0.005) better results group. same difference maintained 0.005). Nutrition strict dietary plan an increase daily calories protein also vitamin mineral supplements young may be effective for faster recovery parameters from its beneficial should studied further this as well other respiratory tract infections.

Language: Английский

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Estimation of Anti-SARS-CoV-2 IgM/IgG Seroprevalence Among Non-Vaccinated and Vaccinated University Students: A Cross-Sectional Egyptian Study

Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 378 - 378

Published: March 6, 2025

It is essential to comprehend the humoral immune response severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its vaccines maximize effectiveness of anti-SARSCoV-2 community immunization efforts. The aim this cross-sectional study was determine seroprevalence anti-SARS-CoV-2 IgM/IgG among newcomer students at Kafr Elsheikh University in Egypt, whether they had been vaccinated or not. Blood samples from 400 healthy (200 non-vaccinated 200 vaccinated) were evaluated for presence using colloidal gold immunochromatography lateral flow immunoassay cards, then results confirmed by specific ELISA tests. prevalence antibodies participants (n = 400) 56.3% IgG 13.3% IgM. Regarding participants, 55.0% females, mean age 18.2 years, BMI 25.35. 58.5% 18.1 25.3. There statistically non-significant correlations (p ˃ 0.05) between gender, BMI, each IgM- IgG-positivity both groups. In total, 41.5% 48.5% IgM-positive IgG-positive non-vaccinated, respectively. Furthermore, 51.5% vaccinated, No significant association immunoglobulins positivity immunological nonsmokers, people who exercise regularly, those take vitamin supplements, eat a balanced diet, use certain herbs noteworthy. Among subjects, 96.6%, 25.0%, 31.9%, 45.7%, 7.8% group, versus 97.2%, 60.6%, 64.2%, 52.3%, 6.4% exercisers, taking eating herbs, 93.5%, 32.3%, 35.5%, 48.4%, 6.5% 100.0%, 63.6%, 81.8%, 45.5%, 4.5% physical supplement users, eaters, herbalists, Persons are free comorbidities, young, non-obese, non-smokers, engage exercise, vitamins, immunostimulant herbal all have strong response, even if not vaccinated. During pandemics, vaccination group should be priority preserve vaccine doses high-risk vulnerable people. Even there lockdown during an anticipated future epidemic pandemic, we prioritize lifestyle choices, along with increasing activity.

Language: Английский

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Vitamin D: A Nutraceutical Supplement at the Crossroad Between Respiratory Infections and COVID-19

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2550 - 2550

Published: March 12, 2025

Even though in mid-2023 the World Health Organization declared end of public health emergency international concern status for COVID-19, many areas uncertainty about SARS-CoV-2 infection pathophysiology remain. Although last 4 years pharmaceutical industries widely invested development effective antiviral treatments and vaccines, large disparities their availability worldwide still exist, thus fostering investigation nutritional supplements as adjuvant therapeutic approaches disease management, especially resource-limited settings. During COVID-19 pandemic, vitamin D has been used an over-the-counter solution to improve evolution, thanks its known immunomodulatory anti-inflammatory actions. Ecological observational studies support a relationship between hypovitaminosis negative outcomes and, according this evidence, several research groups investigated role supplementation protecting from and/or improving evolution. This narrative review is intended offer insights into existing data on D’s biological effects respiratory infections, COVID-19. Furthermore, it will also brief overview complex interplay vaccine-elicited immune response, with special attention anti-COVID-19 vaccines.

Language: Английский

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Correlation Between Vitamin D Deficiency (25(OH)D3) and the Severity of Purulent Oropharyngeal Infections

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2410 - 2410

Published: April 1, 2025

Background: Vitamin D plays a crucial role in immune system function, and its deficiency has been associated with an increased risk of infections. This study investigates the relationship between vitamin severity purulent oropharyngeal infections, considering need for surgical interventions duration hospitalization. Materials Methods: retrospective included patients diagnosed peritonsillar phlegmons, laterocervical abscesses, abscesses. Patients were categorized based on their levels: (<30 ng/mL) optimal levels (≥30 ng/mL). The clinical parameters, length hospitalization, type treatment analyzed. Statistical analyses Student's t-test, chi-square test, ANOVA to assess differences groups. Results: (25(OH)D3) had significantly longer hospital stay (8.50 days vs. 3.24 days, p = 0.001) required more frequent (55.6% 27.8%, 0.002) compared those levels. A trend toward complex regimens was also observed, although this not statistically significant (p > 0.05). Conclusions: These findings suggest that may contribute severe course increasing invasive treatments prolonging highlights importance monitoring potential benefits supplementation preventing managing upper respiratory tract

Language: Английский

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Lower Serum Magnesium Is Associated with Mortality in Severe COVID-19: A Secondary Analysis of a Randomized Trial

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

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ARACOV-02. Specialized nutritional intervention and telerehabilitation in patients with long COVID: Protocol of a randomized controlled trial

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321811 - e0321811

Published: April 29, 2025

Background It is estimated that at least 10% of the population infected with SARS-CoV-2 develop Post COVID Condition, which characterized by a diverse array symptoms including dyspnea, fatigue, anxiety, depression, and deterioration in quality life. The virus can trigger an excessive immune response, release pro-inflammatory cytokines IL-6, IL-1, TNFα reactive oxygen species. Specialized Pro Resolving Mediators (SPMs) (17-HAD, 14-HAD 18_HEPE) could be useful Condition modulating inflammatory response. objective to determine change life, profile, functional capacity emotional variables group taking nutritional supplement plus telerehabilitation programme. Methods ARACOV-2 study double-blind, parallel-group, randomized control trial two parallel interventions: Nutritional vs placebo telerehabilitation. primary endpoint will life (EQ-5L-5D). intervention last 12 weeks daily intake omega-3 or supervised rehabilitation programme using Discussion This suggests SPMs supplementation combined may improve inflammation like fatigue patients. Both interventions have anti-inflammatory potential, their use enhance physical mental health outcomes. approach offers promising strategy for managing symptoms. Trial registration ClinicalTrials.gov NCT06063031

Language: Английский

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Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1650 - 1650

Published: July 24, 2024

Cardiovascular disease and cancer are the two leading causes of morbidity mortality in world. The emerging field cardio-oncology described several shared risk factors that predispose patients to both cardiovascular cancer. Post-acute COVID-19 syndrome is a chronic condition occurs many who have experienced SARS-CoV-2 infection, mainly based on fatigue, sedentary lifestyle, cramps, breathing difficulties, reduced lung performance. exposes increased visceral adiposity, insulin resistance, myosteatosis, white adipose tissue content (surrounded by M1 macrophages characterized Th1/Th17 phenotype), which increases recurrence. In this review, main metabolic affections post-acute at low high cardiomyopathies will be summarized. Furthermore, non-pharmacological strategies aimed reducing atherosclerotic cardiac provided, especially through anti-inflammatory nutrition with glycemic index, appropriate physical activity, immune-modulating bioactivities able reduce obesity improving insulin-related signaling myocardial metabolism.

Language: Английский

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The COVID-19 Pandemic Increased the Risk of Eating Disorders and Emotional Eating Symptoms: A Review of the Current Clinical Evidence

COVID, Journal Year: 2024, Volume and Issue: 4(11), P. 1704 - 1718

Published: Oct. 28, 2024

Background: There has been recent evidence to suggest that people who suffer from eating disorders (EDs) or other behavior disturbances, such as emotional (EE), are particularly vulnerable post-COVID-19. This narrative literature review aims comprehensively analyze and scrutinize the existing clinical studies regarding effects of COVID-19 pandemic on with EDs EE. Moreover, due pandemic, it is very important find out whether a person’s state may lead them wrongly confront their food consumption. Methods: A thorough search several databases (PubMed, Scopus, Web Science, Public Library Google Scholar, CINAHL Complete, PsycINFO, Academic Search Complete) was performed identify available published between 2020 2024 using relevant keywords. Results: substantial exerted negative persons suffering EDs, including those symptomatic, in remission, an EE behavior. Characteristically, diagnosed anorexia nervosa (AN), bulimia (BN), binge disorder (BED) showed considerable symptomatic worsening after first wave pandemic. Clinical investigating have also clearly demonstrated mood disturbances negatively affected behaviors. These shown were at greater risk development progression during Conclusion: The seems significant deleterious effect history related frequency dysfunctional behaviors, thus decreasing therapeutic intervention efficiency well disturbed behaviors In this aspect, further strongly recommended investigate exact explore potential long-term complications post-pandemic period. strategies policies should be applied provide special healthcare for group patients.

Language: Английский

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