Rhythms of life: circadian disruption and brain disorders across the lifespan

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 20(1), P. 49 - 65

Published: Nov. 20, 2018

Language: Английский

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Circadian and sleep dysfunction in Alzheimer’s disease

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 60, P. 101046 - 101046

Published: April 16, 2020

Language: Английский

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Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults

The Lancet Healthy Longevity, Journal Year: 2020, Volume and Issue: 1(3), P. e96 - e105

Published: Nov. 12, 2020

Summary

Background

Circadian disturbances are commonly seen in people with Alzheimer's disease and have been reported individuals without symptoms of dementia but pathology. We aimed to assess the temporal relationship between circadian progression.

Methods

did a prospective cohort study 1401 healthy older adults (aged >59 years) enrolled Rush Memory Aging Project (Rush University Medical Center, Chicago, IL, USA) who had followed up for 15 years. Participants underwent annual assessments cognition (with battery 21 cognitive performance tests) motor activities actigraphy). Four measures were extracted from actigraphy quantify daily rhythmicity, which amplitude 24-h activity rhythm, acrophase (representing peak time), interdaily stability intradaily variability hourly fragmentation rhythm. used Cox proportional hazards models logistic regressions whether predict an increased risk incident conversion mild impairment dementia. linear mixed-effects investigate how rhythms changed longitudinally change integrated

Findings

median age 81·8 (IQR 76·3–85·7) Risk developing was lower (1 SD decrease, hazard ratio [HR] 1·39, 95% CI 1·19–1·62) higher increase, 1·22, 1·04–1·43). In participants impairment, predicted by HR 1·46, 1·24–1·72), 1·36, 1·15–1·60), 1·21, 1·02–1·44). A faster transition odds [OR] 2·08, 1·53–2·93), 1·97, 1·43–2·79), decreased 1·35, 1·01–1·84). amplitude, acrophase, progressively over time, time. progression accelerated these aging effects doubling or more than changes after diagnosis further doubled them The longitudinal global positively correlated negatively variability.

Interpretation

Our results indicate link dysregulation progression, implying either bidirectional relation shared common underlying pathophysiological mechanisms.

Funding

National Institutes Health, BrightFocus Foundation.

Language: Английский

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Gamma Oscillations in Alzheimer’s Disease and Their Potential Therapeutic Role

Frontiers in Systems Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: Dec. 13, 2021

Despite decades of research, Alzheimer’s Disease (AD) remains a lethal neurodegenerative disorder for which there are no effective treatments. This review examines the latest evidence novel and newly introduced perspective, focuses on restoration gamma oscillations investigates their potential role in treatment AD. Gamma brain activity (∼25–100 Hz) has been well-known its cognitive function, including memory, it is fundamental healthy intra-brain communication. Aberrant have observed both mice AD models human patients. A recent line work demonstrated that entrainment, through auditory visual sensory stimulation, can effectively attenuate pathology improve function disease. The first from patients indicate entrainment therapy reduce loss functional connectivity atrophy, ameliorate several pathological markers Even though research still infancy, suggests gamma-based may disease-modifying effect signified new promising era research.

Language: Английский

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The Effect of Aerobic Exercise on Cognitive Function in People with Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(23), P. 15700 - 15700

Published: Nov. 25, 2022

A growing body of research has examined the effect aerobic exercise on cognitive function in people with Alzheimer’s Disease (AD), but findings available studies were conflicting. The aim this study was to explore AD patients. Searches performed PubMed, Web Science, and EBSCO databases from inception indexing until 12 November 2021. Cochrane risk assessment tool used evaluate methodological quality included literature. From 1942 search records initially identified, 15 randomized controlled trials (RCTs) considered eligible for systematic review meta-analysis. Included involved 503 participants 16 groups (mean age: 69.2–84 years) 406 68.9–84 control groups. There a significant increasing mini-mental state examination (MMSE) score patients [weighted mean difference (WMD), 1.50 (95% CI, 0.55 2.45), p = 0.002]. Subgroup analyses showed that interventions conducted 30 min per session [WMD, 2.52 0.84 4.20), 0.003], less than 150 week 2.10 3.37), 0.001], up three times 1.68 0.46 2.89), 0.007] increased MMSE significantly. In addition, worse basal status associated greater improvement score. Our analysis indicated exercise, especially session, week, contributed improving Additionally, more improvements function.

Language: Английский

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Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(4), P. 833 - 845

Published: Aug. 14, 2023

A growing body of evidence suggests that the gut microbiota contributes to development neurodegenerative diseases via microbiota-gut-brain axis. As a contributing factor, dysbiosis always occurs in pathological changes diseases, such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped reveal bidirectional communication between central nervous system enteric is facilitated by microbiota's diverse microorganisms, for both neuroimmune neuroendocrine systems. Here, we summarize bioinformatics analysis wet-biology validation metagenomics with an emphasis on multi-omics studies virome. The pathogen-associated signaling biomarkers identifying brain disorders potential therapeutic targets are also elucidated. Finally, discuss role diet, prebiotics, probiotics, postbiotics exercise interventions remodeling microbiome reducing symptoms diseases.

Language: Английский

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Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease

Acta Physiologica, Journal Year: 2023, Volume and Issue: 238(2)

Published: March 31, 2023

Abstract Dysfunction of circadian and sleep rhythms is an early feature many neurodegenerative diseases. Alzheimer's disease (AD) a progressive disorder resulting in cognitive psychiatric disturbances. Although it largely unclear whether dysfunctions contribute to the etiology AD or are consequence disease, there evidence that these conditions involved complex self‐reinforcing bidirectional relationship. According recent studies, dysregulation clock already occurs during asymptomatic stage could promote neurodegeneration. Thus, restoration preclinical may represent opportunity for intervention slow course.

Language: Английский

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Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7579 - 7579

Published: April 20, 2023

Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired rhythms are associated with mental disorders. The evening chronotype, which misalignment, risk factor for severe psychiatric symptoms metabolic comorbidities. Resynchronization of commonly improves symptoms. Furthermore, evidence indicates that preventing misalignment help reduce disorders impact neuro–immuno–metabolic disturbances in psychiatry. gut microbiota exhibits diurnal rhythmicity, as governed by meal timing, regulates host’s rhythms. Temporal regulation feeding has emerged promising chronotherapeutic strategy prevent and/or treatment illnesses, through modulation microbiota. Here, we provide an overview link between disruption illness. We summarize connection rhythms, supporting idea aid resynchronization disrupted describe microbiome rhythmicity its related factors, highlighting role timing. Lastly, emphasize necessity rationale further research develop effective safe dietary strategies based chrononutrition combat

Language: Английский

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The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

Neuron, Journal Year: 2019, Volume and Issue: 104(4), P. 724 - 735.e6

Published: Sept. 12, 2019

Language: Английский

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The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer’s disease model

The FASEB Journal, Journal Year: 2022, Volume and Issue: 36(3)

Published: Feb. 4, 2022

Alzheimer's disease (AD) is a devastating neurodegenerative disorder, and there pressing need to identify disease-modifying factors devise interventional strategies. The circadian clock, our intrinsic biological timer, orchestrates various cellular physiological processes including gene expression, sleep, neuroinflammation; conversely, dysfunctions are closely associated with and/or contribute AD hallmarks. We previously reported that the natural compound Nobiletin (NOB) clock-enhancing modulator promotes health healthy aging. In current study, we treated double transgenic model mice, APP/PS1, NOB-containing diets. NOB significantly alleviated β-amyloid burden in both hippocampus cortex, exhibited trend improve cognitive function these mice. While several systemic parameters for wheel-running activity, metabolism were unchanged, treatment showed marked effect on expression of clock clock-controlled cortex. accordance, cortical proteomic profiling demonstrated time-dependent restoration protein landscape APP/PS1 mice NOB. More importantly, found potent efficacy inhibit proinflammatory cytokine inflammasome formation immunostaining further revealed specific diminish astrogliosis, but not microgliosis, by Together, results underscore beneficial effects mitigate pathological hallmarks AD, suggest possible mechanism via suppressing astrogliosis-associated neuroinflammation.

Language: Английский

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