Natural Products and Bioprospecting,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 19, 2024
Biotransformation
is
a
process
in
which
molecules
are
modified
the
presence
of
biocatalyst
or
enzymes,
as
well
metabolic
alterations
that
occur
organisms
from
exposure
to
molecules.
Microbial
biotransformation
an
important
natural
product
drug
discovery
novel
compounds
biosynthesised.
Additionally,
products
offer
with
improved
efficacy,
solubility,
reduced
cytotoxic
and
allows
for
understanding
structure
activity
relationships.
One
driving
forces
these
impeccable
findings
associated
cytochrome
P450
monooxygenases
present
all
such
mammals,
bacteria,
fungi.
Numerous
fungal
strains
have
been
used
reported
their
ability
biotransform
different
compounds.
This
review
focused
on
studies
using
Alternaria
species
biocatalysts
facilitates
reactions
favour
stereoselectivity,
regioselectivity
under
mild
conditions.
microbial
products,
application
food,
pharmaceutical
agricultural
sector
discussed
this
review.
Inflammopharmacology,
Journal Year:
2024,
Volume and Issue:
32(6), P. 3953 - 3971
Published: July 4, 2024
Abstract
Parkinsonism
is
an
age-related
neurodegenerative
illness
that
affects
motor
coordination
leading
to
loss
of
dopaminergic
neurons.
Many
medications
are
used
for
the
treatment
Parkinson’s
disease
but
only
symptomatic
and
have
a
limited
effect
on
progression
this
ailment.
Therefore,
bioactive
compounds
which
derived
from
plants
been
examined
their
ability
improve
neuronal
damage
cell
death
happened
in
parkinsonian
patients.
In
study
iridoids-rich
fraction
isolated
Pentas
lanceolata
(PIRF)
leaves
was
investigated
its
phytoconstituents.
Seven
iridoids
(
1
–
7
)
one
flavonol
diglycoside
8
were
isolated,
chemical
structures
achieved
by
H
13
C
nuclear
magnetic
resonance
ESI–MS
spectral
data.
Compound
(6β,7β-epoxy-8-
epi
-splendoside)
5
(gaertneroside)
first
time
genus
as
well
compound
(kaempferol-3-
O
-robinobioside).
The
current
aims
investigate
possible
anti-parkinsonian
PIRF
using
rotenone
model
mice.
Behavioural
tests
(wirehanging,
stair
wooden-walking
tests)
done
examine
mice
after
treatment.
Biochemical
histopathological
examinations
brain
striatum
different
groups
also
evaluated.
Results
revealed
rotenone-treated
had
poor
functions
described
depletion
dopamine
Ach
levels,
significant
increase
proinflammatory
cytokines,
IL-1B,
TNF-α
Mcp-1
oxidative
biomarkers
with
subsequent
reduction
antioxidant
mediators.
Disorganization
striatum,
degenerated
neurocytes,
slight
vacuolation,
shrunken
neurons
pyknotic
nuclei
apoptotic
cells
displayed
examinations.
Treatment
ameliorates
neurodegeneration-induced
could
be
attributed
constituents
iridoids.
Natural Products and Bioprospecting,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 19, 2024
Biotransformation
is
a
process
in
which
molecules
are
modified
the
presence
of
biocatalyst
or
enzymes,
as
well
metabolic
alterations
that
occur
organisms
from
exposure
to
molecules.
Microbial
biotransformation
an
important
natural
product
drug
discovery
novel
compounds
biosynthesised.
Additionally,
products
offer
with
improved
efficacy,
solubility,
reduced
cytotoxic
and
allows
for
understanding
structure
activity
relationships.
One
driving
forces
these
impeccable
findings
associated
cytochrome
P450
monooxygenases
present
all
such
mammals,
bacteria,
fungi.
Numerous
fungal
strains
have
been
used
reported
their
ability
biotransform
different
compounds.
This
review
focused
on
studies
using
Alternaria
species
biocatalysts
facilitates
reactions
favour
stereoselectivity,
regioselectivity
under
mild
conditions.
microbial
products,
application
food,
pharmaceutical
agricultural
sector
discussed
this
review.
