The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study DOI Creative Commons
Zhihao Chen, Luyao Liu,

Xueyan Jiao

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential TG/HDL-C predict development calcific aortic valve disease (CAVD), thereby extending its applicability in diagnostics. Data from 400 individuals, comprising 200 patients with diagnosed CAVD matched healthy controls, were analyzed. Clinical parameters compared between groups, logistic regression was utilized explore association CAVD. diagnostic performance assessed using receiver operating characteristic (ROC) curves. notably higher group than controls (Z = -7.98, P < 0.001). Multivariable analysis indicated that an independent predictor after adjusting confounders including gender. ROC curve revealed achieved sensitivity 80.5%, specificity 59.5%, area under (AUC) 0.731 (P 0.001), confirming efficacy predicting High significantly associated occurrence CAVD, could be used tool assessment indicator Not applicable.

Language: Английский

Deletion of Transient Receptor Channel Vanilloid 4 Aggravates CaCl2-Induced Abdominal Aortic Aneurysm and Vascular Calcification: A Histological Study DOI Creative Commons
Isehaq Al‐Huseini,

Maryam Al-Ismaili,

Ammar Boudaka

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 2566 - 2566

Published: March 19, 2024

Vascular calcification is calcium deposition occurring in the wall of blood vessels, leading to mechanical stress and rupture due a loss elasticity hardening vessel wall. The role Transient Receptor Channel Vanilloid 4 (TRPV4), Ca2+-permeable cation channel, progression vascular poorly explored. In this study, we investigated TRPV4 development abdominal aortic aneurysm (AAA). Experimental mice were randomly divided into four groups: wild-type (WT) sham operated group, WT CaCl2-induced injury, TRPV4-KO injury. TRPV4-knockout (TRPV4-KO) subjected histopathological analysis, aorta showed extensive tunica media with significant increase outer diameter (p < 0.0001), luminal area 0.05), internal circumference 0.05) after CaCl2 injury when compared mice. Additionally, damage apparent elongation disruption elastic lamella. These results indicate protective function against AAA

Language: Английский

Citations

0
Association of Apolipoprotein E Gene Polymorphisms with Risk of Coronary Artery Disease in a Han Chinese Population at Middle and High Altitude in China DOI Creative Commons
Fanrong Zeng,

Xinyi Zhang,

Meng Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Abstract Background This study aimed to assess how APOE gene polymorphisms affect the development of coronary artery disease (CAD) in Han Chinese population at middle and high altitudes by regulating body's lipid levels, which stimulates atherosclerosis. Methods A total 628 CAD non-CAD cases were enrolled this study, respectively. determined PCR fluorescence hybridization techniques. Data analysis was performed using software SPSS 26.0. Results revealed that statistical differences ε3ε4 ε4ε4 genotypes, as well ε4 allele frequencies between control groups, significant (p < 0.05). Furthermore, Apo-B/Apo-A1, Apo-B, LDL-C levels statistically higher patients carrying than those ε2 ε3 alleles. Moreover, multifactorial logistic regression gene's genotype (OR = 1.514, 95% CI 1.087–2.109, p 0.014) independent risk factor (IRF) for intermediate altitudes. Conclusion gene’s is a potential onset

Language: Английский

Citations

0
Therapeutic potentials of peptide-derived nanoformulations in atherosclerosis: present status and future directions DOI Creative Commons
Xue Liu, Weijiao Wang, Qiang Li

et al.

International Journal of Smart and Nano Materials, Journal Year: 2024, Volume and Issue: 15(3), P. 610 - 651

Published: July 2, 2024

Atherosclerosis is a severe cardiovascular disease followed by the accumulation of atherosclerotic plaques within lumen blood vessels resulting in reduced flow thus initiating series events. Conventional therapies for atherosclerosis encounter multiple challenges, especially difficulty precisely concentrating certain affected regions and potential unwanted side effects. Consequently, scientists are focused on developing nanoformulations diagnosis therapy. Peptide-based nanomedicines improve conventional offering improved structural therapeutic stability enabling target-specific delivery. Their inherent biocompatibility biodegradability additionally render them desirable materials intended vivo use. This review manuscript aims to provide an in-depth overview peptide-based atherosclerosis, focusing targeted cells like endothelial cells, macrophages, monocytes their interaction with different plaque components. Moreover, also highlights latest progress multimodal techniques provides comprehensive limitations associated practical implementation.

Language: Английский

Citations

0
The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study DOI Creative Commons
Zhihao Chen, Luyao Liu,

Xueyan Jiao

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 19, 2024

The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential TG/HDL-C predict development calcific aortic valve disease (CAVD), thereby extending its applicability in diagnostics. Data from 400 individuals, comprising 200 patients with diagnosed CAVD matched healthy controls, were analyzed. Clinical parameters compared between groups, logistic regression was utilized explore association CAVD. diagnostic performance assessed using receiver operating characteristic (ROC) curves. notably higher group than controls (Z = -7.98, P < 0.001). Multivariable analysis indicated that an independent predictor after adjusting confounders including gender. ROC curve revealed achieved sensitivity 80.5%, specificity 59.5%, area under (AUC) 0.731 (P 0.001), confirming efficacy predicting High significantly associated occurrence CAVD, could be used tool assessment indicator Not applicable.

Language: Английский

Citations

0