Predicting Sprint Potential: A Machine Learning Model Based on Blood Metabolite Profiles in Young Male Athletes

European Journal of Sport Science, Journal Year: 2025, Volume and Issue: 25(3)

Published: Feb. 24, 2025

ABSTRACT This study aims to utilize male blood metabolite signatures for (i) distinguishing between healthy individuals and athletes, thereby optimizing the athlete screening process; (ii) predicting athletic performance in 100, 200, 400 m sprints, enhancing precompetition preparation intervention strategies. Initially, we employed nontargeted metabolomics analyze metabolome of ( n = 10) athletes 10), identifying differential expressed metabolites (DEMs) potentially related through analysis, consensus clustering, WGCNA, UMAP analysis. Subsequently, using LASSO‐Cox refined our selection two core DEMs: HMDB0012085 (Sphingomyelin (d18:0/14:0)) HMDB0009224 (Phosphatidylethanolamine(20:0/18:1(9Z))) associated with performance. We then applied targeted measure levels these DEMs a larger cohort, including 50) 100), revealing significant increase compared individuals. Utilizing 13 machine learning classification methods, demonstrated that effectively differentiate athletes. Notably, exhibits greater feature importance across multiple algorithms HMDB0009224. Specifically, decision trees (94.1 vs. 5.9), random forests (60.7 39.3), gradient boosting (91.5 8.5), CatBoost (61.7 38.3), ExtraTrees (64.7 35.3), XGBoost (74.5 25.5). Finally, found negative correlation whole sprint times races. In conclusion, hold promise as biomarkers potential males.

Language: Английский

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Comparative Efficacy of Various Exercise Types on Cancer‐Related Fatigue for Cancer Survivors: A Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(7)

Published: March 27, 2025

ABSTRACT Background This study compares the effectiveness of 7 types guideline‐recommended first‐line exercises for cancer‐related fatigue (CRF). Methods A comprehensive search was conducted utilizing public databases, including Medline, Embase, Web Science, and Cochrane Library. Randomized clinical trials examining effects aerobic exercise, resistance stretching combined Yoga, Qigong, or Tai Chi on CRF in various cancer were included. Bayesian network meta‐analysis used to synthesize data. Subgroup analyses sensitivity detect effect modifiers confirm robustness, respectively. Results total 33 included this analysis. Overall, both (SMD, −1.72; 95% CI, −2.81 −0.63) Yoga −1.27; −1.38 −1.16) reduced severity significantly better than standard care, but there no significant decrease other exercise types. For survivors with an age over 55 years, only showed statistically improvement −1.16). patients less −1.75; −2.91 −0.58) −1.66; −0.51) compared care. Conclusion Both yoga benefits alleviating particularly effective years age, while comparably those under years.

Language: Английский

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Metabolomics Analysis Reveals Potential Biomarkers for Diffuse Axonal Injury Article Category: Original Work

Neurocritical Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Language: Английский

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Combined Mediterranean Diet-based Sustainable Healthy Diet and Multicomponent Training intervention impact on plasma biomarkers and metabolome in older adults

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(9), P. 2125 - 2135

Published: July 26, 2024

Healthy dietary patterns and exercise practices have been associated with improved metabolic inflammatory profiles. However, studies regarding the combined effect of these interventions on plasma biomarkers metabolome in older adults are sparser. The primary aim this study was to investigate impact a Mediterranean Diet-based Sustainable Diet (SHD) Multicomponent Training (MT) intervention how intake could modulate effects.

Language: Английский

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Wearable Solid-Phase Microextraction Sampling for Enhanced Detection of Volatile Analytes in Human Ears

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1318, P. 342923 - 342923

Published: July 2, 2024

Language: Английский

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Does Vitamin B6 Act as an Exercise Mimetic in Skeletal Muscle?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9962 - 9962

Published: Sept. 15, 2024

Marginal vitamin B6 (B6) deficiency is common in various segments worldwide. In a super-aged society, sarcopenia major concern and has gained significant research attention focused on healthy aging. To date, the primary interventions for have been physical exercise therapy. Recent evidence suggests that inadequate status associated with an increased risk of mortality among older adults. Our previous study showed supplementation to marginal B6-deficient diet up-regulated expression exercise-induced genes skeletal muscle rodents. Notably, supplemental B6-to-B6-deficient stimulates satellite cell-mediated myogenesis rodents, mirroring effects exercise. These findings suggest potential role as exercise-mimetic nutrient muscle. test this hypothesis, we reviewed relevant literature compared roles muscles. Here, provide several pieces supporting hypothesis discuss mechanisms behind similarities between This research, first time, provides insight into

Language: Английский

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Metabolic characteristics of ischaemic preconditioning induced performance improvement in Taekwondo athletes using LC‒MS/MS-based plasma metabolomics

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 19, 2024

Language: Английский

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The Relationship between Changes in MYBPC3 Single-Nucleotide Polymorphism-Associated Metabolites and Elite Athletes’ Adaptive Cardiac Function

Journal of Cardiovascular Development and Disease, Journal Year: 2023, Volume and Issue: 10(9), P. 400 - 400

Published: Sept. 18, 2023

Athletic performance is a multifactorial trait influenced by complex interaction of environmental and genetic factors. Over the last decades, understanding improving elite athletes’ endurance has become real challenge for scientists. Significant tools include but are not limited to development molecular methods talent identification, personalized exercise training, dietary requirements, prevention exercise-related diseases, as well recognition structure function genome in athletes. Investigating markers phenotypes critical surveillance. The identification variants contributing predisposition excellence certain types athletic activities been difficult despite relatively high inheritance athlete status. Metabolomics can potentially represent useful approach gaining thorough various physiological states clarifying disorders caused strength–endurance physical exercise. Based on previous GWAS study, this manuscript aims discuss association specific single-nucleotide polymorphisms (SNPs) located MYBPC3 gene encoding cardiac MyBP-C protein with linked heart remodeling during or after exercise, it could also be phenotype hypertrophy (HCM). To make distinction between both phenotypes, metabolites that analyzed relation HCM. These theophylline, ursodeoxycholate, quinate, decanoyl-carnitine. According analysis effect size, decanoyl carnitine increase while decreasing cardiovascular disease, whereas ursodeoxycholate increases disease. In conclusion, based our metabolomics data, effects each SNP-associated metabolite discussed.

Language: Английский

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A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(1), P. 166 - 182

Published: March 20, 2024

To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for analysis plasma samples before and after personalized intervention. Consisting aerobic resistance exercises, this intervention associated with significant molecular changes that correlated improvements lean mass, appendicular skeletal muscle index (ASMI), performance 400-m walk test (MWT) sit-to-stand test. These alterations indicated exercise-induced modulation inflammation mitochondrial function markers. This case study provides proof-of-principal application multiomics-based assessments supervised exercise, thereby supporting as feasible beneficial PDAC patients to potentially enhance response patient quality life. The observed here underscore importance activity cancer protocols, advocating development accessible multiomics-guided programs patients.

Language: Английский

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Insights into the Serum Metabolic Adaptations in Response to Inspiratory Muscle Training: A Metabolomic Approach Based on 1H NMR and UHPLC-HRMS/MS

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16764 - 16764

Published: Nov. 25, 2023

Inspiratory muscle training (IMT) is known to promote physiological benefits and improve physical performance in endurance sports activities. However, the metabolic adaptations promoted by different IMT prescribing strategies remain unclear. In this work, a longitudinal, randomized, double-blind, sham-controlled, parallel trial was performed investigate effects of 11 weeks (3 days·week-1) at exercise intensities on serum metabolomics profile its main regulated pathways. Twenty-eight healthy male recreational cyclists (30.4 ± 6.5 years) were randomized into three groups: sham (6 cm·H2O inspiratory pressure, n = 7), moderate-intensity (MI group, 60% maximal pressure (MIP), 11) high-intensity (HI 85-90% MIP, 10). Blood samples collected before after analyzed 1H NMR UHPLC-HRMS/MS. Data using linear mixed models metabolite set enrichment analysis. The UHPLC-HRMS/MS techniques resulted 46 200 compounds, respectively. These results showed that ketone body metabolism, fatty acid biosynthesis, aminoacyl-tRNA biosynthesis upregulated IMT, while alpha linolenic linoleic metabolism as well unsaturated acids downregulated. MI group presented higher Tryptophan, Valine levels but decreased 2-Hydroxybutyrate when compared other two studied groups. suggest an increase oxidative processes with additional evidence for upregulation essential amino accompanied greater improvement respiratory strength.

Language: Английский

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