Action Mechanisms of Medicinal Plant Components as Antimycosis: A Literature Review DOI Creative Commons
Mohamed El‐Sakhawy,

Ghadah S. Abusalim,

Ahmed Ashour

et al.

Salud Ciencia y Tecnología, Journal Year: 2025, Volume and Issue: 5, P. 1647 - 1647

Published: March 12, 2025

Mycosis poses a significant threat to global health, particularly in immune-compromised individuals, and the rise of antifungal resistance has further complicated their treatment. The fungal infections (FIs) is growing concern, contributing significantly morbidity mortality rates. Medicinal plants (MPs), with long history use traditional medicine, have emerged as valuable source bioactive compounds potent properties. current study explores mechanisms by which plant active constituents (PACs) exert effects, including inhibition cell membrane (CM) wall (CW) synthesis, mitochondrial dysfunction, Nucleic acids (Nas) protein synthesis (PS), inhibiting electron transport chain, decreasing ATP production, glycolysis, oxidative phosphorylation, oxygen uptake cells, this lead affect division, /or its mycelial growth spore germination. Compounds such flavonoids, alkaloids, terpenoids, other PACs demonstrated activity through these diverse mechanisms, offering potential alternatives conventional drugs. This highlights MPs foundation for developing novel therapies. Furthermore, it underscores importance understanding intraocular action (MsOA) combat improve therapeutic outcomes. comprehensive analysis not only validates medicine but also provides roadmap future research drug development fight against FIs. aligns supports sustainable goals (SDGs), good health well-being (SDG 3) goals.

Language: Английский

Oxidative Stress: The Role of Antioxidant Phytochemicals in the Prevention and Treatment of Diseases DOI Open Access
Adele Muscolo, Mariateresa Oliva, Torello Giulio

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3264 - 3264

Published: March 13, 2024

Oxidative stress, characterized by an imbalance favouring oxidants over antioxidants, is a key contributor to the development of various common diseases. Counteracting these considered effective strategy mitigate levels oxidative stress in organisms. Numerous studies have indicated inverse correlation between consumption vegetables and fruits risk chronic diseases, attributing health benefits presence antioxidant phytochemicals foods. Phytochemicals, present wide range foods medicinal plants, play pivotal role preventing treating diseases induced working as antioxidants. These compounds exhibit potent antioxidant, anti-inflammatory, anti-aging, anticancer, protective properties against cardiovascular diabetes mellitus, obesity, neurodegenerative conditions. This comprehensive review delves into significance averting managing elucidating sources invaluable elements. Additionally, it provides summary recent advancements understanding associated with phytochemicals.

Language: Английский

Citations

97
Recent Developments in Citrus aurantium L.: An Overview of Bioactive Compounds, Extraction Techniques, and Technological Applications DOI Open Access
Joaquín Fernández-Cabal, Kevin Alejandro Avilés-Betanzos, Juan Valerio Cauich‐Rodríguez

et al.

Processes, Journal Year: 2025, Volume and Issue: 13(1), P. 120 - 120

Published: Jan. 5, 2025

This review provides an overview of recent developments in Citrus aurantium L. (sour or bitter orange), focusing on its bioactive compounds, innovative extraction techniques, and technological applications. C. is rich compounds such as flavonoids (naringin, hesperidin, kaempferol, quercetin), essential oils (β-pinene, limonene), vitamin C, which represents significant biological activities including antioxidant, antimicrobial, anti-inflammatory, anticancer effects. The discusses traditional methods, solvent hydrodistillation, alongside newer, eco-friendly approaches like ultrasound-assisted extraction, microwave-assisted supercritical fluid natural deep eutectic solvents. It also highlights cutting-edge molecular imprinting polymer-based enable the more efficient enrichment purification specific synephrine. Finally, examines diverse industrial applications these sectors foods, pharmaceuticals, cosmetics, while emphasizing growing need for sustainable technologies.

Language: Английский

Citations

3
Heat Stress and Plant–Biotic Interactions: Advances and Perspectives DOI Creative Commons
Rahul Mahadev Shelake, Sopan Ganpatrao Wagh, Akshay Milind Patil

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(15), P. 2022 - 2022

Published: July 23, 2024

Climate change presents numerous challenges for agriculture, including frequent events of plant abiotic stresses such as elevated temperatures that lead to heat stress (HS). As the primary driving factor climate change, HS threatens global food security and biodiversity. In recent years, have negatively impacted physiology, reducing plant's ability maintain disease resistance resulting in lower crop yields. Plants must adapt their priorities toward defense mechanisms tolerate challenging environments. Furthermore, selective breeding long-term domestication higher yields made varieties vulnerable multiple stressors, making them more susceptible events. Studies on predict concurrent biotic will become severe future, potentially occurring simultaneously or sequentially. While most studies focused singular effects systems examine how plants respond specific stresses, simultaneous occurrence pose a growing threat agricultural productivity. Few explored interactions between plant-biotic interactions. Here, we aim shed light physiological molecular (bacteria, fungi, oomycetes, nematodes, insect pests, pollinators, weedy species, parasitic plants), well combined impact growth We also advances designing developing various strategies address multi-stress scenarios related factors.

Language: Английский

Citations

12
Biofungicides Based on Plant Extracts: On the Road to Organic Farming DOI Open Access
Antonio de Jesús Cenobio-Galindo, Alma Delia Hernández-Fuentes, Uriel González-Lemus

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6879 - 6879

Published: June 22, 2024

Phytopathogenic fungi are responsible for diseases in commercially important crops and cause major supply problems the global food chain. Plants were able to protect themselves from disease before humans played an active role protecting plants. They known synthesize a variety of secondary metabolites (SMs), such as terpenes, alkaloids, phenolic compounds, which can be extracted using conventional unconventional techniques formulate biofungicides; plant extracts have antifungal activity various mechanisms action against these organisms. In addition, they considered non-phytotoxic potentially effective control. sustainable economically viable alternative use agriculture, is why biofungicides increasingly recognized attractive option solve caused by synthetic fungicides. Currently, organic farming continues grow, highlighting importance developing environmentally friendly alternatives crop production. This review provides compilation literature on biosynthesis, phytopathogens, extraction formulation biofungicides, biological phytopathogenic fungi, regulation, advantages, disadvantages overview current agriculture.

Language: Английский

Citations

11
Selective breeding of cold-tolerant black soldier fly (Hermetia illucens) larvae: Gut microbial shifts and transcriptional patterns DOI
Chong Ma, Zhijun Huang,

Xingbao Feng

et al.

Waste Management, Journal Year: 2024, Volume and Issue: 177, P. 252 - 265

Published: Feb. 13, 2024

Language: Английский

Citations

8
Model-based fed-batch cultivation of Viola odorata plant cells exhibiting antimalarial and anticancer activity DOI Creative Commons
R. Narendra Babu, Manokaran Veeramani, W. Aadinath

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 29, 2025

Introduction Viola odorata is a medicinal plant used in the indigenous systems of medicine India, to treat respiratory tract disorders. V. natural source limited availability. Bioprocess principles can be applied develop sustainable methods for commercial production high-quality biomass. Methods To this effect, vitro culture conditions were rationally optimized increase biomass up 21.7 ± 0.8 g DW L −1 12 days shake flasks. In current study, modified stirred tank reactor and balloon-type bubble column improve at batch level. Sufficient nutrient feeding strategies developed using first principle-based mathematical modelling overcome substrate inhibition achieve higher cell density reactor. addition, bioreactor-cultivated extracts (aqueous/alcoholic) tested various bioactivities like hemolytic, cytotoxic, anti-inflammatory, antiplasmodial. Results Experimental validation fed-batch model-predicted strategy resulted two-fold enhancement (32.2 ) bioreactor Biomass showed no hemolytic activity 4 mg mL concentrations. Further, cultivated extract displayed cytotoxicity against Caco2 - colon carcinoma lines, exhibiting an IC50 1.5 0.1 . experiments also indicated anti-inflammatory property extracts. As new application, demonstrated 80% malarial parasite growth Additionally, when administered alongside artesunate (1.8 kg d ), (400 effectively controlled vivo Discussion It noted that report on cultivation suspension lab-scale bioreactors antiplasmodial Overall, bioactive potential -generated similar

Language: Английский

Citations

1
Glycyrrhizin and its derivatives: an emerging secondary metabolite arsenal of Glycyrrhiza glabra DOI
Aadil Rasool, Tanveer Ali Dar

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

1
Dynamic molecular regulation of salt stress responses in maize (Zea mays L.) seedlings DOI Creative Commons

Ailijiang Maimaiti,

Wei Gu, Diansi Yu

et al.

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 25, 2025

Maize ranks among the most essential crops globally, yet its growth and yield are significantly hindered by salt stress, posing challenges to agricultural productivity. To utilize saline-alkali soils more effectively enrich maize germplasm resources, identifying salt-tolerant genes in is essential. In this study, we used a inbred line, SPL02, salt-sensitive Mo17. We treated both lines with 180 mmol/L sodium chloride (NaCl) for 0 days, 3 6 9 days at three-leaf stage (V3). Through comprehensive morphological, physiological, transcriptomic analyses, assessed stress effects identified hub pathways associated tolerance. Our analysis 25,383 expressed genes, substantial differences gene expression patterns across treatment stages. found 8,971 differentially (DEGs)-7,111 unique SPL02 4,791 Mo17-indicating dynamic changes under stress. DEGs primarily MAPK signaling pathway, phenylpropanoid biosynthesis, hormone conditions. Mo17, responses mediated through abscisic acid-activated pathway response. Additionally, our weighted co-expression network (WGCNA) pinpointed five that likely play central roles mediating These functions including phosphate import ATP-binding protein, glycosyltransferase, WRKY transcription factors. This study offers valuable insights into complex regulatory networks governing response identifies further investigation. findings contribute knowledge enhancing resilience sustainability saline-affected environments.

Language: Английский

Citations

1
Review green synthesis of silver nanoparticles by using plant extracts and their antimicrobial activity DOI Creative Commons
Emad Abada, Abdullah Mashraqi, Yosra Modafer

et al.

Saudi Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 31(1), P. 103877 - 103877

Published: Nov. 26, 2023

Interest in the biosynthesis of nanoparticles has increased last era by researchers. Nanoparticles have several applications different fields like optoelectronics, magnetic devices, drug delivery, and sensors. Nanoparticle synthesis green methods is safe for environment should be explored encouraged popularly since various plants' high extent to form these nanoparticles. Worldwide, UV spectroscopy, X-ray diffraction, Transmission Electron Microscopy (TEM), Scanning (SEM), Dynamic Light Scattering (DLS), Atomic Force (AFM) besides Fourier Transform Infrared Spectroscopy (FTIR) are used many ways characterize The most advantageous use AgNPs their great attribution as antimicrobial agents. Finally, concept deserved modern technical medical concern. current review shows a complete comprehensive analytical survey with particular focus on activities antimicrobials possible theories effect microbial cell all influenced secondary metabolites.

Language: Английский

Citations

20
Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy DOI Open Access
Anna Stasiłowicz-Krzemień, Anna Gościniak, Dorota Formanowicz

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6937 - 6937

Published: June 25, 2024

Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, cornerstone in cancer treatment, aims destroy cells while minimizing harm healthy tissues. However, the harmful effects irradiation on normal present formidable obstacle. To mitigate these effects, researchers have explored using radioprotectors and mitigators, including natural compounds derived from secondary plant metabolites. This review outlines diverse classes compounds, elucidating their roles as protectants cells. Furthermore, highlights potential radioprotective agents capable enhancing body's resilience radiation therapy. By integrating into treatment regimens, clinicians may improve therapeutic outcomes adverse Ongoing research this area holds promise for developing complementary strategies optimize radiotherapy efficacy enhance patient quality life.

Language: Английский

Citations

7