Effects of Globularia cordifolia on colon cancer cells: antioxidant activity, inflammatory cytokine analysis and molecular docking studies DOI Open Access
Emine İncilay Torunoğlu, Erdi Can Aytar, Betül Aydın

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract BACKGROUND The present study aimed to comprehensively evaluate the anticancer, anti‐inflammatory, and antioxidant properties of Globularia cordifolia L. samples. plant material was collected extracted using maceration method. Antioxidant activities were assessed through DPPH (i.e. 2,2‐diphenyl‐1‐picrylhydrazyl) iron chelation assays, whereas phenolic flavonoid contents measured spectrophotometric methods. Gas chromatography‐mass spectrometry analysis performed identify biologically active compounds. cytotoxic effect on colon cancer cells evaluated MTT [i.e. 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide] inflammatory cytokine levels an enzyme‐linked immunosorbent assay. Molecular docking studies investigated interactions bioactive compounds with 4UYA protein, ADME absorption, distribution, metabolism, excretion toxicity) modeling predicted their toxicity. RESULTS revealed that extract exhibited strong activity a median 50% inhibitory concentration (IC 50 ) value 39.48 ± 2.15 μg mL −1 in assay effective capacity IC 4.28 0.19 mg . total content 662.51 20.95 gallic acid equivalents g , 114.99 0.51 quercetin demonstrating extract's richness Significant antiproliferative effects observed at dose 250 Inflammatory indicated reduction pro‐inflammatory responses. showed binding affinities between suggesting mechanisms action. CONCLUSION findings indicate G. exhibits antioxidant, anti‐inflammatory properties, making it promising biomolecular agent for therapy. high contents, combined compounds' key molecular targets, underscore its potential therapeutic applications. © 2024 Society Chemical Industry.

Language: Английский

Biologically Synthesized Nanoparticles for Enhancing Secondary Metabolites in Plant Tissue Cultures DOI

Athira Sajeev,

Insha Asheem,

Ravishankar Patil

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

1
Impact of zinc oxide nanoparticles and iron on Stevia rebaudiana Bertoni growth, nutrient uptake, and bioactive compounds under in vitro conditions DOI

Seyed Mohammad Javad Lankarani,

Jaber Karimi, Ayatollah Rezaei

et al.

Plant Cell Tissue and Organ Culture (PCTOC), Journal Year: 2024, Volume and Issue: 159(1)

Published: Oct. 1, 2024

Language: Английский

Citations

1
Nanoparticles as Elicitors and Harvesters of Economically Important Secondary Metabolites in Plants DOI
Sanchaita Lala

Reference series in phytochemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 1, 2024

Language: Английский

Citations

0
Green Synthesis, Characterization and Pharmaceutical Applications of Biocompatible Zinc Oxide Nanoparticles Using Heliotropium rariflorum Stocks DOI Creative Commons
Noor Ul Uza, Ghulam Dastagir, Syed Tanveer Shah

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1457 - 1457

Published: Oct. 31, 2024

Zinc oxide nanoparticles are safe, non-toxic, and biocompatible. These NPs used in food packaging materials, self-cleaning glass, ceramics, deodorants, sunscreens, paints, coatings, ointments, lotions, as preservatives. This study explored the biological potential of ZnO synthesized using

Language: Английский

Citations

0
Effects of Globularia cordifolia on colon cancer cells: antioxidant activity, inflammatory cytokine analysis and molecular docking studies DOI Open Access
Emine İncilay Torunoğlu, Erdi Can Aytar, Betül Aydın

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Abstract BACKGROUND The present study aimed to comprehensively evaluate the anticancer, anti‐inflammatory, and antioxidant properties of Globularia cordifolia L. samples. plant material was collected extracted using maceration method. Antioxidant activities were assessed through DPPH (i.e. 2,2‐diphenyl‐1‐picrylhydrazyl) iron chelation assays, whereas phenolic flavonoid contents measured spectrophotometric methods. Gas chromatography‐mass spectrometry analysis performed identify biologically active compounds. cytotoxic effect on colon cancer cells evaluated MTT [i.e. 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide] inflammatory cytokine levels an enzyme‐linked immunosorbent assay. Molecular docking studies investigated interactions bioactive compounds with 4UYA protein, ADME absorption, distribution, metabolism, excretion toxicity) modeling predicted their toxicity. RESULTS revealed that extract exhibited strong activity a median 50% inhibitory concentration (IC 50 ) value 39.48 ± 2.15 μg mL −1 in assay effective capacity IC 4.28 0.19 mg . total content 662.51 20.95 gallic acid equivalents g , 114.99 0.51 quercetin demonstrating extract's richness Significant antiproliferative effects observed at dose 250 Inflammatory indicated reduction pro‐inflammatory responses. showed binding affinities between suggesting mechanisms action. CONCLUSION findings indicate G. exhibits antioxidant, anti‐inflammatory properties, making it promising biomolecular agent for therapy. high contents, combined compounds' key molecular targets, underscore its potential therapeutic applications. © 2024 Society Chemical Industry.

Language: Английский

Citations

0