Epigenetic control of skeletal muscle atrophy

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: July 8, 2024

Abstract Skeletal muscular atrophy is a complex disease involving large number of gene expression regulatory networks and various biological processes. Despite extensive research on this topic, its underlying mechanisms remain elusive, effective therapeutic approaches are yet to be established. Recent studies have shown that epigenetics play an important role in regulating skeletal muscle atrophy, influencing the numerous genes associated with condition through addition or removal certain chemical modifications at molecular level. This review article comprehensively summarizes different types DNA, histones, RNA, their known regulators. We also discuss how epigenetic change during process by which proteins control assess translational potential. The stem cells highlighted. In addition, we propose alternative splicing interacts regulate mass, offering novel perspective enhances our understanding inheritance’s network governing atrophy. Collectively, advancements provide invaluable insights into study Moreover, knowledge paves way for identifying new avenues development more strategies pharmaceutical interventions.

Language: Английский

Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 30, 2024

Language: Английский

Muscle‐Derived Bioactive Factors: MyoEVs and Myokines

Cell Proliferation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Overview of the functions and applications myokines MyoEVs.

Language: Английский