The Roles of Neuroinflammation in l‐DOPA‐Induced Dyskinesia: Dissecting the Roles of NF‐κB and TNF‐α for Novel Pharmacological Therapeutic Approaches DOI Open Access
Mohammad Yasin Zamanian, Maryam Golmohammadi, Zhanna R. Gardanova

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(5)

Published: March 1, 2025

ABSTRACT Levodopa‐induced dyskinesia (LID) is a common and debilitating complication of long‐term Parkinson's disease treatment. This review explores the roles NF‐κB TNF‐α signalling pathways in LID pathophysiology potential therapeutic approaches targeting these mechanisms. Chronic levodopa treatment leads to aberrant neuroplasticity neuroinflammation, involving activation increased production pro‐inflammatory cytokines like TNF‐α. glial cells contributes sustained neuroinflammation exacerbates dopaminergic neuron loss. levels are elevated brain regions affected by correlate with severity. Several compounds involved mitigating modulating pathways. Agmatine reduces NMDA receptor expression while protecting neurons. Resveratrol doxycycline demonstrate antidyskinetic effects attenuating production. The Rho‐kinase (ROCK) inhibitor fasudil cannabinoid 2 (CB2) agonists also show efficacy reducing severity neuroinflammation. Hydrogen gas inhalation decreases cytokine associated LID. These findings highlight complex interplay between NF‐κB, other neurotransmitter systems pathogenesis. Targeting through represents promising strategy for developing novel treatments. Further research needed fully elucidate mechanisms optimize

Language: Английский

The Roles of Neuroinflammation in l‐DOPA‐Induced Dyskinesia: Dissecting the Roles of NF‐κB and TNF‐α for Novel Pharmacological Therapeutic Approaches DOI Open Access
Mohammad Yasin Zamanian, Maryam Golmohammadi, Zhanna R. Gardanova

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(5)

Published: March 1, 2025

ABSTRACT Levodopa‐induced dyskinesia (LID) is a common and debilitating complication of long‐term Parkinson's disease treatment. This review explores the roles NF‐κB TNF‐α signalling pathways in LID pathophysiology potential therapeutic approaches targeting these mechanisms. Chronic levodopa treatment leads to aberrant neuroplasticity neuroinflammation, involving activation increased production pro‐inflammatory cytokines like TNF‐α. glial cells contributes sustained neuroinflammation exacerbates dopaminergic neuron loss. levels are elevated brain regions affected by correlate with severity. Several compounds involved mitigating modulating pathways. Agmatine reduces NMDA receptor expression while protecting neurons. Resveratrol doxycycline demonstrate antidyskinetic effects attenuating production. The Rho‐kinase (ROCK) inhibitor fasudil cannabinoid 2 (CB2) agonists also show efficacy reducing severity neuroinflammation. Hydrogen gas inhalation decreases cytokine associated LID. These findings highlight complex interplay between NF‐κB, other neurotransmitter systems pathogenesis. Targeting through represents promising strategy for developing novel treatments. Further research needed fully elucidate mechanisms optimize

Language: Английский

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