Microbiome-Metabolome Analysis Insight into the Effects of the Extract of Phyllanthus emblica L. on High-Fat Diet-Induced Hyperlipidemia DOI Creative Commons
Jiahao Wang,

Jijing Dong,

Furong Zhong

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(5), P. 257 - 257

Published: April 29, 2024

The fruit of Phyllanthus emblica L. (FEPE) has a long history use in Asian folk medicine. main bioactive compounds FEPE are polyphenols, known for their potent antioxidant, anti-inflammatory, and hypolipidemic activities. present study aimed to investigate the intervention effect (100 200 mg/kg) on hyperlipidemia 8 weeks preliminarily explored potential mechanism by microbiome-metabolome analysis. results showed that high-dose (200 effectively alleviated dyslipidaemic symptoms body weight gain hyperlipidemic mice induced high-fat diet (HFD). Microbiome analysis altered structure intestinal microbiota, which included an increase specific probiotics (such as Akkermansia, Anaerovorax, Bacteroides) decrease harmful bacteria (including A2, Acetitomaculum, Candidatus_Arthromitus, Lachnospiraceae_NK4A136_group, Lachnospiraceae_NK4B4_group, Rikenella, Streptococcus), well reduction level short-chain fatty acids (SCFAs). In addition, significant changes hepatic metabolome were observed, eight key metabolites associated with betaine metabolism, lysine degradation, methionine acid metabolism pathways primarily filtered. correlated identified several “microbiota-metabolite” axes treatment extract. conclusion, is expected provide basis treating from perspective microbiome-liver axis.

Language: Английский

Microbiome-Metabolome Analysis Insight into the Effects of the Extract of Phyllanthus emblica L. on High-Fat Diet-Induced Hyperlipidemia DOI Creative Commons
Jiahao Wang,

Jijing Dong,

Furong Zhong

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(5), P. 257 - 257

Published: April 29, 2024

The fruit of Phyllanthus emblica L. (FEPE) has a long history use in Asian folk medicine. main bioactive compounds FEPE are polyphenols, known for their potent antioxidant, anti-inflammatory, and hypolipidemic activities. present study aimed to investigate the intervention effect (100 200 mg/kg) on hyperlipidemia 8 weeks preliminarily explored potential mechanism by microbiome-metabolome analysis. results showed that high-dose (200 effectively alleviated dyslipidaemic symptoms body weight gain hyperlipidemic mice induced high-fat diet (HFD). Microbiome analysis altered structure intestinal microbiota, which included an increase specific probiotics (such as Akkermansia, Anaerovorax, Bacteroides) decrease harmful bacteria (including A2, Acetitomaculum, Candidatus_Arthromitus, Lachnospiraceae_NK4A136_group, Lachnospiraceae_NK4B4_group, Rikenella, Streptococcus), well reduction level short-chain fatty acids (SCFAs). In addition, significant changes hepatic metabolome were observed, eight key metabolites associated with betaine metabolism, lysine degradation, methionine acid metabolism pathways primarily filtered. correlated identified several “microbiota-metabolite” axes treatment extract. conclusion, is expected provide basis treating from perspective microbiome-liver axis.

Language: Английский

Citations

6