Exploring the genetic link between gastroesophageal reflux disease and pancreatic cancer: insights from Mendelian randomization DOI Creative Commons
Chen Yang, Fan Ge,

Mengye Peng

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 18, 2025

Gastroesophageal reflux disease (GERD) is increasingly recognized for its associations with extragastric diseases, yet potential role in pancreatic cancer (PC) etiology remains underexplored. This study investigates the genetic causal relationship between GERD and PC using Mendelian randomization (MR), a method designed to reduce confounding factors. A two-sample MR analysis was conducted genome-wide association studies (GWAS) data. The inverse variance weighted (IVW) applied, additional sensitivity analyses performed evaluate pleiotropy heterogeneity. IVW demonstrated significant signature predisposing an increased risk of (OR: 1.36, 95% CI: 1.04-1.80, P = 0.03). There no evidence (P 0.71) or heterogeneity 0.94). Our provides robust supporting that predisposition associated PC. These findings emphasize necessity integrating into assessments encourage further research elucidate underlying biological mechanisms. insight holds inform strategies early detection, prevention, personalized management patients.

Language: Английский

Gut Microbiota Serves as a Crucial Independent Biomarker in Inflammatory Bowel Disease (IBD) DOI Open Access
Bharti Sharma,

George Agriantonis,

Kate Twelker

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2503 - 2503

Published: March 11, 2025

Inflammatory bowel disease (IBD), encompassing Crohn’s (CD), ulcerative colitis (UC), and IBD unclassified (IBD-U), is a complex intestinal disorder influenced by genetic, environmental, microbial factors. Recent evidence highlights the gut microbiota as pivotal biomarker modulator in pathogenesis. Dysbiosis, characterized reduced diversity altered composition, hallmark of IBD. A consistent decrease anti-inflammatory bacteria, such Faecalibacterium prausnitzii, an increase pro-inflammatory species, including Escherichia coli, have been observed. Metabolomic studies reveal decreased short-chain fatty acids (SCFAs) secondary bile acids, critical for homeostasis, alongside elevated metabolites. The interacts with host immune pathways, influencing morphogens, glycosylation, podoplanin (PDPN) expression. disruption glycosylation impairs mucosal barriers, while aberrant PDPN activity exacerbates inflammation. Additionally, alterations contribute to oxidative stress, further destabilizing barriers. These molecular cellular disruptions underscore role microbiome pathophysiology. Emerging therapeutic strategies, probiotics, prebiotics, dietary interventions, aim restore balance mitigate Advanced on microbiota-targeted therapies their potential reduce severity improve patient outcomes. Nevertheless, research needed elucidate bidirectional interactions between responses translate these insights into clinical applications. This review consolidates current findings microbiota’s IBD, emphasizing its diagnostic implications, advocates continued exploration microbiome-based interventions combat this debilitating disease.

Language: Английский

Citations

1
Salting-out assisted liquid-liquid extraction for UPLC-MS/MS determination of bile acids and kynurenine-, indole- and serotonin-pathway metabolites of tryptophan in human serum of healthy probands DOI Creative Commons

Celine Oanes,

Marina Alexeeva,

Kjetil Søreide

et al.

Journal of Chromatography B, Journal Year: 2025, Volume and Issue: 1255, P. 124519 - 124519

Published: Feb. 11, 2025

Language: Английский

Citations

0
Rosuvastatin inhibits carcinogenesis through Ca2+ triggered endoplasmic reticulum stress pathway in pancreatic cancer DOI
Hui Miao, Baojian Zhang, Yue Li

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111753 - 111753

Published: March 1, 2025

Language: Английский

Citations

0
Exploring the genetic link between gastroesophageal reflux disease and pancreatic cancer: insights from Mendelian randomization DOI Creative Commons
Chen Yang, Fan Ge,

Mengye Peng

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 18, 2025

Gastroesophageal reflux disease (GERD) is increasingly recognized for its associations with extragastric diseases, yet potential role in pancreatic cancer (PC) etiology remains underexplored. This study investigates the genetic causal relationship between GERD and PC using Mendelian randomization (MR), a method designed to reduce confounding factors. A two-sample MR analysis was conducted genome-wide association studies (GWAS) data. The inverse variance weighted (IVW) applied, additional sensitivity analyses performed evaluate pleiotropy heterogeneity. IVW demonstrated significant signature predisposing an increased risk of (OR: 1.36, 95% CI: 1.04-1.80, P = 0.03). There no evidence (P 0.71) or heterogeneity 0.94). Our provides robust supporting that predisposition associated PC. These findings emphasize necessity integrating into assessments encourage further research elucidate underlying biological mechanisms. insight holds inform strategies early detection, prevention, personalized management patients.

Language: Английский

Citations

0