Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol® on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy—A Randomized Placebo-Controlled Double-Blind Trial DOI Open Access

Jasmin Bayer,

Nicole Petersen,

Jeanine Veruschka Hess

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1546 - 1546

Published: April 30, 2025

Background: Gingival inflammation is highly prevalent and may impact systemic health. While professional mechanical plaque removal (PMPR) the standard treatment, dietary interventions provide additional benefits. The French maritime pine bark extract Pycnogenol® has anti-inflammatory antioxidant properties, but its on inflammatory biomarkers in saliva serum not been studied a controlled clinical trial. Methods: In this randomized, double-blind, placebo-controlled trial, 91 participants received (100 mg twice daily; n = 46) or placebo (n 45) following PMPR. Saliva samples were collected at baseline, after two three months. Inflammatory (IL-1β, IL-6, MMP-8, MMP-9) polyphenol concentrations analyzed using ELISA LC-MS/MS. Results: supplementation significantly reduced salivary MMP-8 levels (p 0.0261), IL-6 compared to 0.0409). Additionally, ferulic acid, caffeic gut microbial metabolite 5-(3,4-dihydroxyphenyl)-γ-valerolactone (M1) increased intake. A correlation analysis revealed significant inverse association between bleeding probing M1 concentration (r -0.3476, p 0.0167). Conclusions: Dietary with key saliva, suggesting potential effect of gingival inflammation. Trial registration: ClinicalTrials.gov (NCT05786820).

Language: Английский

Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol® on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy—A Randomized Placebo-Controlled Double-Blind Trial DOI Open Access

Jasmin Bayer,

Nicole Petersen,

Jeanine Veruschka Hess

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1546 - 1546

Published: April 30, 2025

Background: Gingival inflammation is highly prevalent and may impact systemic health. While professional mechanical plaque removal (PMPR) the standard treatment, dietary interventions provide additional benefits. The French maritime pine bark extract Pycnogenol® has anti-inflammatory antioxidant properties, but its on inflammatory biomarkers in saliva serum not been studied a controlled clinical trial. Methods: In this randomized, double-blind, placebo-controlled trial, 91 participants received (100 mg twice daily; n = 46) or placebo (n 45) following PMPR. Saliva samples were collected at baseline, after two three months. Inflammatory (IL-1β, IL-6, MMP-8, MMP-9) polyphenol concentrations analyzed using ELISA LC-MS/MS. Results: supplementation significantly reduced salivary MMP-8 levels (p 0.0261), IL-6 compared to 0.0409). Additionally, ferulic acid, caffeic gut microbial metabolite 5-(3,4-dihydroxyphenyl)-γ-valerolactone (M1) increased intake. A correlation analysis revealed significant inverse association between bleeding probing M1 concentration (r -0.3476, p 0.0167). Conclusions: Dietary with key saliva, suggesting potential effect of gingival inflammation. Trial registration: ClinicalTrials.gov (NCT05786820).

Language: Английский

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