Metabolomics Profiling Reveals Critical Roles of Indoxyl Sulfate in the Regulation of Innate Monocytes in COVID-19 DOI Creative Commons
Liqing He, Yunke Wang, Fang Yuan

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 256 - 256

Published: Feb. 11, 2025

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is intricately related to the reprogramming of host metabolism. However, existing studies have mainly focused on peripheral blood samples and barely identified specific metabolites that are critically involved in pathology disease 2019 (COVID-19). In current small-scale study, we performed metabolic profiling plasma (n = 61) paired bronchoalveolar lavage fluid (BALF) 20) using parallel two-dimensional liquid chromatography–mass spectrometry (2DLC-MS). addition, studied how an metabolite regulates immunopathogenesis COVID-19. results unveiled distinct metabolome changes between healthy donors, moderate patients both BALF, indicating locations severity play critical roles COVID-19 alteration. Notably, a vital metabolite, indoxyl sulfate, was found be elevated BALF patients. Indoxyl sulfate selectively induced TNF-α production, reduced co-stimulatory signals, enhanced apoptosis human monocytes. Moreover, its levels negatively correlated with strength signals antigen presentation capability monocytes Collectively, our findings suggest could potentially serve as functional biomarker monitor progression guide more individualized treatment for

Language: Английский

Metabolomics Profiling Reveals Critical Roles of Indoxyl Sulfate in the Regulation of Innate Monocytes in COVID-19 DOI Creative Commons
Liqing He, Yunke Wang, Fang Yuan

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 256 - 256

Published: Feb. 11, 2025

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is intricately related to the reprogramming of host metabolism. However, existing studies have mainly focused on peripheral blood samples and barely identified specific metabolites that are critically involved in pathology disease 2019 (COVID-19). In current small-scale study, we performed metabolic profiling plasma (n = 61) paired bronchoalveolar lavage fluid (BALF) 20) using parallel two-dimensional liquid chromatography–mass spectrometry (2DLC-MS). addition, studied how an metabolite regulates immunopathogenesis COVID-19. results unveiled distinct metabolome changes between healthy donors, moderate patients both BALF, indicating locations severity play critical roles COVID-19 alteration. Notably, a vital metabolite, indoxyl sulfate, was found be elevated BALF patients. Indoxyl sulfate selectively induced TNF-α production, reduced co-stimulatory signals, enhanced apoptosis human monocytes. Moreover, its levels negatively correlated with strength signals antigen presentation capability monocytes Collectively, our findings suggest could potentially serve as functional biomarker monitor progression guide more individualized treatment for

Language: Английский

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