The Analyst,
Journal Year:
2022,
Volume and Issue:
148(1), P. 9 - 25
Published: Dec. 7, 2022
Recent
years
have
witnessed
the
emergence
of
innovative
analytical
methods
with
high
sensitivity
and
spatiotemporal
resolution
that
allowed
qualitative
quantitative
analysis
to
be
carried
out
at
single-cell
subcellular
levels.
Electrochemiluminescence
(ECL)
is
a
unique
chemiluminescence
high-energy
electron
transfer
triggered
by
electrical
excitation.
The
ingenious
combination
electrochemistry
results
in
distinct
advantages
sensitivity,
wide
dynamic
range
good
reproducibility.
Specifically,
ECL
(SCECL)
excellent
has
emerged
as
promising
toolbox
bioanalysis
for
revealing
individual
cells'
heterogeneity
stochastic
processes.
This
review
focuses
on
advances
SCECL
bioimaging.
history
recent
probes
strategies
system
design
are
briefly
reviewed.
Subsequently,
latest
representative
techniques
bioassays,
bioimaging
therapeutics
also
highlighted.
Then,
current
challenges
future
perspectives
discussed.
Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(25), P. 8857 - 8866
Published: June 14, 2022
In
this
study,
a
carbon
paste
filling
method
was
proposed
as
simple
strategy
for
fabricating
high-density
bipolar
electrode
(BPE)
arrays
electrochemical
microscopy
(BEM).
High
spatiotemporal
resolution
imaging
achieved
using
the
fabricated
BPE
array.
BEM,
which
is
an
emerging
microscopic
system
in
recent
years,
achieves
label-free
and
high
of
molecular
distributions
electrochemiluminescence
(ECL)
signals.
We
devised
to
fabricate
array
by
porous
plate
with
succeeded
(15
μm
pitch).
After
detailed
observation
surface
scanning
electron
microscope,
basic
ECL
emission
characteristics
were
evaluated
potassium
ferricyanide
solution
sample
solution.
Moreover,
inflow
molecules
conducted
evaluate
ability
prepared
addition,
Prussian
Blue
containing
ink
applied
side
provide
catalytic
activity
hydrogen
peroxide,
quantification
peroxide
signals
achieved.
This
fabrication
can
accelerate
research
development
BEM.
Furthermore,
BEM
important
milestone
achieving
bioimaging
such
biomolecule
enzymes.
Molecules,
Journal Year:
2023,
Volume and Issue:
29(1), P. 1 - 1
Published: Dec. 19, 2023
The
excessive
concentration
of
heavy-metal
mercury
ions
(Hg2+)
in
the
environment
seriously
affects
ecological
and
even
threatens
human
health.
Therefore,
it
is
necessary
to
develop
rapid
low-cost
determination
methods
achieve
trace
detection
Hg2+.
In
this
paper,
an
Electrochemiluminescence
(ECL)
sensing
platform
using
a
functionalized
rare-earth
material
(cerium
oxide,
CeO2)
as
luminescent
unit
aptamer
capture
was
designed
constructed.
Using
specific
asymmetric
matching
between
Hg2+
thymine
(T)
base
pairs
deoxyribonucleic
acid
(DNA)
single
strand,
“T−Hg−T”
structure
formed
change
ECL
signal,
leading
direct
sensitive
response
results
show
good
linear
relationship
signal
within
range
10
pM–100
µM
for
Hg2+,
with
limit
low
0.35
pM.
addition,
probe
exhibits
stable
performance
excellent
specificity
identifying
target
It
then
successfully
used
spiked
recovery
tests
actual
samples
environment.
analytical
method
solves
problem
poor
recognition
specificity,
provides
new
idea
efficient
pollutant
environment,
broadens
prospects
development
application
materials.
ChemElectroChem,
Journal Year:
2021,
Volume and Issue:
8(18), P. 3492 - 3498
Published: June 10, 2021
Abstract
A
2D
imaging
system
using
closed
bipolar
electrodes
(cBPEs)
and
electrochemiluminescence
(ECL)
is
expected
to
realize
high
spatio‐temporal
resolution
imaging.
However,
of
the
distributions
molecules
that
cause
an
oxidation
reaction
on
electrode
surface
was
not
achieved
by
cBPE/ECL
because
conventionally
used
luminophore
can
generate
ECL
only
reaction.
In
this
paper,
we
propose
implement
a
cathodic
luminophore,
[Ru(bpy)
3
]Cl
2
/glutathione
disulfide
(GSSG)
producing
reduction
into
enable
detection
dopamine,
which
oxidizable
redox
species
important
neurotransmitter.
The
applicability
/GSSG
for
dopamine
single
cBPE
shown
its
electrochemical
properties
were
discussed.
addition,
demonstration
performed
array.
These
results
show
potential
greatly
expand
systems
cBPE/ECL.
ACS Applied Electronic Materials,
Journal Year:
2021,
Volume and Issue:
3(9), P. 4180 - 4188
Published: Sept. 13, 2021
Electrogenerated
chemiluminescence
(ECL)
is
a
phenomenon
of
light
emission
from
molecular
species
that
triggered
by
an
electrochemical
reaction.
As
with
many
systems,
ECL
highly
dependent
on
the
electrode
material
and
its
surface
state.
Boron-doped
diamond
(BDD)
has
been
applied
for
ECL,
however,
thoughtful
investigation
remains
scarce.
In
particular,
peculiar
feature
BDD
tuning
properties
changing
amount
boron
doping
which
in
turn
affects
response.
Here,
we
summarize
results
most
important
such
as
Ru(bpy)32+
(bpy
=
2,2′-bipyridine)/tri-n-propylamine
(TPrA),
Ru(bpy)32+/S2O82–,
Ru(bpy)32+/SO42–,
Ru(bpy)32+/CO32–,
luminol/CO32–
system,
using
correlating
level
to
We
showed
suitable
state
are
system
investigated,
highlighting
importance
right
choice
electrode.
While
focused
these
offer
general
interpretation
might
be
adapted
different
systems
where
finds
application.
The Analyst,
Journal Year:
2022,
Volume and Issue:
148(1), P. 9 - 25
Published: Dec. 7, 2022
Recent
years
have
witnessed
the
emergence
of
innovative
analytical
methods
with
high
sensitivity
and
spatiotemporal
resolution
that
allowed
qualitative
quantitative
analysis
to
be
carried
out
at
single-cell
subcellular
levels.
Electrochemiluminescence
(ECL)
is
a
unique
chemiluminescence
high-energy
electron
transfer
triggered
by
electrical
excitation.
The
ingenious
combination
electrochemistry
results
in
distinct
advantages
sensitivity,
wide
dynamic
range
good
reproducibility.
Specifically,
ECL
(SCECL)
excellent
has
emerged
as
promising
toolbox
bioanalysis
for
revealing
individual
cells'
heterogeneity
stochastic
processes.
This
review
focuses
on
advances
SCECL
bioimaging.
history
recent
probes
strategies
system
design
are
briefly
reviewed.
Subsequently,
latest
representative
techniques
bioassays,
bioimaging
therapeutics
also
highlighted.
Then,
current
challenges
future
perspectives
discussed.
