Advanced Drug Delivery Systems for Topical Insulin in Diabetic Wound Healing

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(44)

Published: Nov. 1, 2024

Abstract Diabetes mellitus is a chronic condition characterized by impaired insulin production or utilization, leading to serious complications such as diabetic foot ulcers (DFUs). DFUs are wounds with high levels of inflammatory cytokines, arterial occlusion, and persistent infection, often resulting in significant morbidity. Traditional treatment methods, including debridement, offloading, infection control, have shown limited success, prompting the exploration novel therapeutic strategies. Insulin, known for its role glucose metabolism, also possesses wound‐healing properties promoting cell proliferation, protein synthesis, modulating inflammation. However, systemic administration not ideal due hypoglycemia risks difficulties achieving concentrations at wound sites. This review focuses on advanced drug delivery systems topical application dressings. Various platforms, hydrogels, nanoparticles, liposomes, microemulsions been developed optimize bioavailability, protect it from degradation, ensure controlled release. These aim enhance management addressing multifactorial nature healing patients. The provides comprehensive overview current advancements, evaluates efficacy these preclinical clinical studies, discusses challenges future perspectives this field. By highlighting potential innovative approaches, underscores promise improving patient outcomes.

Language: Английский

---

Cytotoxicity properties of green synthesized cupric oxide nanoparticles on neural cells: Rat pheochromocytoma (PC-12) cells and melanoma stem cells A375 cells

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 160, P. 111935 - 111935

Published: Dec. 19, 2023

Language: Английский

---

Synergistic Antifungal Efficiency of Eco-Friendly Synthesized Zinc Oxide Nanoparticles in Combination with Fluconazole against Drug-Resistant Candidal Strains

Polish Journal of Environmental Studies, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

The resistance of fungal pathogens to traditional antifungal medications presents a significant public health concern, particularly for immunocompromised patients, leading elevated rates illness and death.This study aimed explore the properties zinc oxide nanoparticles (ZnO NPs) produced using natural approach involving aqueous seed extract Trigonella foenumgracium (Fenugreek).Additionally, assessed combined effectiveness these biologically synthesized ZnO NPs with fluconazole against pathogens.The were observed have hexagonal shape an average diameter 27 nm surface charge -18.3 mV.Notably, exhibited most potent activity Candida tropicalis, relative inhibition zone 18.67±0.56mm.The minimum inhibitory concentration C. tropicalis was determined be 100 µg/mL, while fungicidal found 200 µg/mL.The greatest synergistic effect between glabrata, followed by parapsilosis.In summary, underscores potential combining formulate effective treatment drug-resistant pathogens, thereby enhancing therapeutic efficacy conventional drugs.

Language: Английский

---

Green Synthesis of Luminescent Carbon Dots from Ficus benghalensis Aerial Roots for Bioimaging

Journal of Fluorescence, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Language: Английский

---

Biosynthesis of Ocimum basilicum leaf extract mediated zinc oxide nanoparticles and their cytotoxic activity

Biomass Conversion and Biorefinery, Journal Year: 2023, Volume and Issue: 13(9), P. 8373 - 8380

Published: May 2, 2023

Language: Английский

---