Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114288 - 114288
Published: Oct. 5, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 607 - 607
Published: Jan. 13, 2025
Antibiotic resistance in microorganisms is an escalating global concern, exacerbated by their formation of biofilms, which provide protection through extracellular matrix and communication via quorum sensing, enhancing to treatment. This situation has driven the search for alternative approaches, particularly those using natural compounds. study explores potential phytochemicals, such as quercetin, apigenin, arbutin, gallic acid, proanthocyanidins, rutin, known antibacterial properties ability inhibit biofilm disrupt mature biofilms. The methods used this included a comprehensive review current literature assessing bioavailability, distribution, effective concentrations these compounds treating biofilm-associated infections. results indicate that phytochemicals exhibit significant effects, reduce biofilm’s structural integrity, bacterial pathways. Moreover, use combination with existing antibiotics may enhance therapeutic outcomes. findings support conclusion offer promising additions anti-biofilm strategies are capable complementing or replacing conventional treatments, appropriate levels delivery mechanisms being key effectiveness. insight underscores need further research into clinical applications infections complicated
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 194 - 194
Published: Feb. 4, 2025
Background: The skin represents the first barrier of defense, and its integrity is crucial for overall health. Skin wounds present a considerable risk seeing how their progression rapid sometimes they are caused by comorbidities like diabetes venous diseases. Nutraceutical combinations ones between polyphenols metal ions applications thanks to increased bioavailability ability modulate intrinsic molecular pathways. Methods: research findings presented in this paper based on systematic review current literature with an emphasis nanotechnology regenerative medicine strategies that incorporate metallic nanoparticles (NPs). key studies which described action mechanisms, efficacy, safety these hybrid formulations were reviewed. Results: Nanocomposites polyphenol promote healing activating signaling pathways such as PI3K/Akt ERK1/2, turn improve fibroblast migration proliferation. Nanoparticles silver copper have antibacterial, angiogenesis-promoting, inflammation-modulating capabilities. With induce apoptosis restrict cell growth, composites potential cure malignancies addition facilitating wound healing. Conclusions: metals provide hope treatment cancer chronic wounds. Their antimicrobial capabilities, capacity inflammatory responses, enhancement activity all point medicinal potential. Furthermore, decrease inflammation associated tumors while simultaneously inducing death cells. Clarifying guaranteeing stability, enhancing effective delivery techniques clinical usage should be focus future studies.
Language: Английский
Citations
0
Materials Advances, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Quercetin, a bioactive flavonoid with limited bioavailability, was investigated using BSA-coated MnFe 2 O 4 nanoparticles as novel delivery system.
Language: Английский
Citations
0
World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(4)
Published: April 1, 2025
Language: Английский
Citations
0
Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2025, Volume and Issue: unknown, P. 223 - 229
Published: April 7, 2025
Objectives: This study aims to develop and evaluate quercetin-loaded silver nanoparticles (Q-AgNPs) as a potential therapeutic agent against cervical cancer, assessing their cytotoxic effects on HeLa cell lines. Methods: Quercetin was synthesized into AgNPs using bioreduction method involving nitrate, with subsequent characterization performed ultraviolet (UV)-Visible spectroscopy, Fourier Transform Infrared X-ray diffraction, scanning electron microscopy. The cytotoxicity of Q-AgNPs evaluated in vitro cancer cells the MTT assay determine viability calculate IC50 value. Results: revealed successful synthesis, distinctive peaks observed UV-Visible spectroscopy confirming interaction between quercetin silver. particle size analysis indicated range sizes, an entrapment efficiency 85.4%. assessment demonstrated dose-dependent decrease viability, value calculated at 11.765 μg/mL, indicating significant effects. Conclusion: findings highlight promising innovative approach for therapy. Further optimization vivo studies are warranted explore mechanisms action enhance efficacy this nanoparticle formulation.
Language: Английский
Citations
0
Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 161, P. 108527 - 108527
Published: April 26, 2025
Language: Английский
Citations
0
Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114682 - 114682
Published: May 1, 2025
Language: Английский
Citations
0
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: unknown, P. 107156 - 107156
Published: Nov. 1, 2024
Language: Английский
Citations
1
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114288 - 114288
Published: Oct. 5, 2024
Language: Английский
Citations
0