Green Technologies and Sustainability, Journal Year: 2024, Volume and Issue: unknown, P. 100152 - 100152
Published: Nov. 1, 2024
Language: Английский
Tissue Engineering and Regenerative Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Language: Английский
Citations
1
Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 340, P. 103470 - 103470
Published: March 7, 2025
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
We demonstrated the implementation of a machine-learning-mediated approach to identify secondary structures proteins based on different spectral and structural descriptors.
Language: Английский
Citations
0
Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 32
Published: Jan. 25, 2025
The cytosolic delivery of therapeutic proteins represents a promising strategy for addressing diseases caused by protein dysfunction. Despite significant advances, efficient remains challenging due to barriers such as cell membrane impermeability, endosomal sequestration, and instability. This review summarizes recent progress in systems, including physical, chemical, biological approaches, with particular focus on strategies that enhance escape targeting specificity. We further discuss the clinical translatability these approaches propose future directions improving efficiency safety, ultimately unlocking potential intracellular proteins.
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 13, 2025
Therapeutic protein delivery has ushered in a promising new generation of disease treatment, garnering more recognition for its clinical potential than ever. However, proteins' limited stability, extremely short average half-lives, and evidenced toxicity following systemic continue to undercut their efficacy. Biomaterial-based delivery, however, demonstrates the overcome these obstacles. To this end, we have developed heparinized alginate collagen hydrogel local, sustained therapeutic proteins. In an effort match ubiquitous application various states target tissues with sufficient versatility, identified three distinct modes as design targets. A shear-thinning, low-viscosity injectable minimal tissue damage, higher-viscosity gel plug subcutaneous injection, submillimeter-thickness film solid-form implantation were optimized characterized work. vitro assessments confirmed feasible injection control, mechanical stability up 6 h unsubmerged storage, isotropic early fibril assembly. Release kinetics assessed both vivo, demonstrating 14 days functional vascular endothelial growth factor delivery. Rodent models pulmonary hypertension, myocardial infarction, applications therapeutics, used assess biocompatibility gel, plug, film, respectively. Histological evaluation delivered materials surrounding showed high cell blood vessel infiltration, remodeling, integration host tissue. Our successful customization biomaterial heterogeneous versatile capacity proteins diverse array regenerative medicine applications.
Language: Английский
Citations
0
Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 367 - 412
Published: April 25, 2025
Because biomaterials can improve tissue repair and regeneration, their use in wound healing has drawn much attention. Biomaterials facilitate cellular connections, create favorable microenvironments, offer mechanical support, making them vital for promoting healing. These materials fall into three categories: natural, synthetic, hybrid. Natural polymers such as collagen, alginate, chitosan mimic the extracellular matrix biocompatibility, while synthetic like PLGA provide adjustable qualities strength degradation rates. Advanced hydrogels, nanoparticles, electrospun fibers enhance moisture retention, control drug release, reduce infection. They release bioactive chemicals growth factors antimicrobial peptides, preventing chronic wounds. This chapter examines various used healing, therapeutic uses, modes of action, well future developments challenges design, scalability.
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: May 9, 2025
Pulmonary hypertension (PH) is still an aggressive and progressive illness with vascular remodeling right heart failure despite the therapeutic advances made in recent past. Biomaterials offer attractive route to break current paradigms by inducing repair, facilitating drug targeting, allowing dynamic regeneration of tissue. This review taking integrated approach investigates revolutionary role played novel biomaterials bio–nano interfaces PH treatment. We classify evaluate several classes biomaterial platforms including natural polymers, scaffolds based on synthetic extracellular vesicles (EVs), stimulus-responsive systems emphasis both underlying mechanisms clinical relevance. further address progress artificial intelligence (AI)-based integrating multi-omics tools provide patient-tailored therapy. finally touch ongoing limitations enumerate future directions required take forward biomaterial-based therapies towards reality.
Language: Английский
Citations
0
Green Technologies and Sustainability, Journal Year: 2024, Volume and Issue: unknown, P. 100152 - 100152
Published: Nov. 1, 2024
Language: Английский
Citations
1