Nanotechnology-Enhanced siRNA Delivery: Revolutionizing Cancer Therapy DOI

Donya Esmaeilpour,

Matineh Ghomi, Ehsan Nazarzadeh Zare‬

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

RNA interference (RNAi) has emerged as a transformative approach for cancer therapy, enabling precise gene silencing through small interfering (siRNA). However, the clinical application of siRNA-based treatments faces challenges such rapid degradation, inefficient cellular uptake, and immune system clearance. Nanotechnology-enhanced siRNA delivery revolutionized therapy by addressing these limitations, improving stability, tumor-specific targeting, therapeutic efficacy. Recent advancements in nanocarrier engineering have introduced innovative strategies to enhance safety precision therapies, offering new opportunities personalized medicine. This review highlights three key innovations nanotechnology-enhanced delivery: artificial intelligence (AI)-driven design, multifunctional nanoparticles combined strategies, biomimetic nanocarriers enhanced biocompatibility. AI-driven utilize machine learning algorithms optimize nanoparticle properties, drug release profiles minimizing off-target effects. Multifunctional integrate with chemotherapy, immunotherapy, or photothermal synergistic treatment approaches that outcomes reduce resistance. Biomimetic nanocarriers, including exosome-mimicking systems cell-membrane-coated nanoparticles, improve circulation time, evasion, targeted tumor delivery. These collectively precision, efficiency, therapies. The scope novelty lie their ability overcome primary barriers while paving way clinically viable solutions. provides comprehensive analysis latest developments fabrication, preclinical studies, assessments. By integrating multifunctionality, biomimicry, holds immense potential future therapy.

Language: Английский

Improved Biomineralization Using Cellulose Acetate/Magnetic Nanoparticles Composite Membranes DOI Open Access
Mădălina Oprea, Andreea Mădălina Pandele, Aurelia Cristina Nechifor

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 209 - 209

Published: Jan. 15, 2025

Following implantation, infections, inflammatory reactions, corrosion, mismatches in the elastic modulus, stress shielding and excessive wear are most frequent reasons for orthopedic implant failure. Natural polymer-based coatings showed especially good results achieving better cell attachment, growth tissue-implant integration, it was found that inclusions of nanosized fillers coating structure improves biomineralization consequently osseointegration, as nanoparticles represent calcium phosphate nucleation centers lead to deposition highly organized hydroxyapatite crystallites on surface. In this study, magnetic synthesized by co-precipitation method were used preparation cellulose acetate composite through phase-inversion method. The ability membranes tested Taguchi method, nanostructured formed at surface membrane (with a higher organization degree purity, Ca/P percentage closer one seen with stoichiometric hydroxyapatite, compared deposited neat acetate). obtained indicate potential new application field orthopedics.

Language: Английский

Citations

0

Lipid nanoparticles for treatment of glioblastoma multiforme: current status of research and clinical translation DOI Creative Commons
Mugdha Kulkarni, Karthik Nadendla, Ananth Pai

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106891 - 106891

Published: April 1, 2025

Language: Английский

Citations

0

Nanoparticle‐Based Therapeutics for Glioblastoma Multiforme Treatment DOI
Papihra Sethi, Shampa Ghosh, Krishna Kumar Singh

et al.

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Glioblastoma multiforme (GBM) is a grade 4 primary malignant brain neoplasm with poor prognosis. GBM has an average survival of 12–18 months despite aggressive treatments, such as maximal safe resection, radiation, and chemotherapy temozolomide. always associated high incidences treatment resistance recurrence, which largely driven by glioma stem cells presents significant therapeutic challenges. The blood–brain barrier (BBB) the most obstacle in treating since it restricts delivery agents to tumor site. Recent advancements nanotechnology offer promising alternatives overcome restrictions, enabling targeted drug significantly reducing systemic toxicity. Additionally, discussing various types nanoparticles liposomes, lipid‐based, dendrimers, polymeric, metallic that have shown promise preclinical models for become pertinent. These can attach glioblastoma using antigens membrane receptors site‐directed targeting. Furthermore, potential cross BBB, enhancing minimizing off‐target effects. This review explores latest nanoparticle‐based therapies their revolutionize treatment, particularly through precise targeting controlled release within microenvironment.

Language: Английский

Citations

0

Nanotechnology-Enhanced siRNA Delivery: Revolutionizing Cancer Therapy DOI

Donya Esmaeilpour,

Matineh Ghomi, Ehsan Nazarzadeh Zare‬

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

RNA interference (RNAi) has emerged as a transformative approach for cancer therapy, enabling precise gene silencing through small interfering (siRNA). However, the clinical application of siRNA-based treatments faces challenges such rapid degradation, inefficient cellular uptake, and immune system clearance. Nanotechnology-enhanced siRNA delivery revolutionized therapy by addressing these limitations, improving stability, tumor-specific targeting, therapeutic efficacy. Recent advancements in nanocarrier engineering have introduced innovative strategies to enhance safety precision therapies, offering new opportunities personalized medicine. This review highlights three key innovations nanotechnology-enhanced delivery: artificial intelligence (AI)-driven design, multifunctional nanoparticles combined strategies, biomimetic nanocarriers enhanced biocompatibility. AI-driven utilize machine learning algorithms optimize nanoparticle properties, drug release profiles minimizing off-target effects. Multifunctional integrate with chemotherapy, immunotherapy, or photothermal synergistic treatment approaches that outcomes reduce resistance. Biomimetic nanocarriers, including exosome-mimicking systems cell-membrane-coated nanoparticles, improve circulation time, evasion, targeted tumor delivery. These collectively precision, efficiency, therapies. The scope novelty lie their ability overcome primary barriers while paving way clinically viable solutions. provides comprehensive analysis latest developments fabrication, preclinical studies, assessments. By integrating multifunctionality, biomimicry, holds immense potential future therapy.

Language: Английский

Citations

0