Improved Biomineralization Using Cellulose Acetate/Magnetic Nanoparticles Composite Membranes
Polymers,
Journal Year:
2025,
Volume and Issue:
17(2), P. 209 - 209
Published: Jan. 15, 2025
Following
implantation,
infections,
inflammatory
reactions,
corrosion,
mismatches
in
the
elastic
modulus,
stress
shielding
and
excessive
wear
are
most
frequent
reasons
for
orthopedic
implant
failure.
Natural
polymer-based
coatings
showed
especially
good
results
achieving
better
cell
attachment,
growth
tissue-implant
integration,
it
was
found
that
inclusions
of
nanosized
fillers
coating
structure
improves
biomineralization
consequently
osseointegration,
as
nanoparticles
represent
calcium
phosphate
nucleation
centers
lead
to
deposition
highly
organized
hydroxyapatite
crystallites
on
surface.
In
this
study,
magnetic
synthesized
by
co-precipitation
method
were
used
preparation
cellulose
acetate
composite
through
phase-inversion
method.
The
ability
membranes
tested
Taguchi
method,
nanostructured
formed
at
surface
membrane
(with
a
higher
organization
degree
purity,
Ca/P
percentage
closer
one
seen
with
stoichiometric
hydroxyapatite,
compared
deposited
neat
acetate).
obtained
indicate
potential
new
application
field
orthopedics.
Language: Английский
Lipid nanoparticles for treatment of glioblastoma multiforme: current status of research and clinical translation
Journal of Drug Delivery Science and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106891 - 106891
Published: April 1, 2025
Language: Английский
Nanoparticle‐Based Therapeutics for Glioblastoma Multiforme Treatment
Advanced Therapeutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Abstract
Glioblastoma
multiforme
(GBM)
is
a
grade
4
primary
malignant
brain
neoplasm
with
poor
prognosis.
GBM
has
an
average
survival
of
12–18
months
despite
aggressive
treatments,
such
as
maximal
safe
resection,
radiation,
and
chemotherapy
temozolomide.
always
associated
high
incidences
treatment
resistance
recurrence,
which
largely
driven
by
glioma
stem
cells
presents
significant
therapeutic
challenges.
The
blood–brain
barrier
(BBB)
the
most
obstacle
in
treating
since
it
restricts
delivery
agents
to
tumor
site.
Recent
advancements
nanotechnology
offer
promising
alternatives
overcome
restrictions,
enabling
targeted
drug
significantly
reducing
systemic
toxicity.
Additionally,
discussing
various
types
nanoparticles
liposomes,
lipid‐based,
dendrimers,
polymeric,
metallic
that
have
shown
promise
preclinical
models
for
become
pertinent.
These
can
attach
glioblastoma
using
antigens
membrane
receptors
site‐directed
targeting.
Furthermore,
potential
cross
BBB,
enhancing
minimizing
off‐target
effects.
This
review
explores
latest
nanoparticle‐based
therapies
their
revolutionize
treatment,
particularly
through
precise
targeting
controlled
release
within
microenvironment.
Language: Английский
Nanotechnology-Enhanced siRNA Delivery: Revolutionizing Cancer Therapy
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 12, 2025
RNA
interference
(RNAi)
has
emerged
as
a
transformative
approach
for
cancer
therapy,
enabling
precise
gene
silencing
through
small
interfering
(siRNA).
However,
the
clinical
application
of
siRNA-based
treatments
faces
challenges
such
rapid
degradation,
inefficient
cellular
uptake,
and
immune
system
clearance.
Nanotechnology-enhanced
siRNA
delivery
revolutionized
therapy
by
addressing
these
limitations,
improving
stability,
tumor-specific
targeting,
therapeutic
efficacy.
Recent
advancements
in
nanocarrier
engineering
have
introduced
innovative
strategies
to
enhance
safety
precision
therapies,
offering
new
opportunities
personalized
medicine.
This
review
highlights
three
key
innovations
nanotechnology-enhanced
delivery:
artificial
intelligence
(AI)-driven
design,
multifunctional
nanoparticles
combined
strategies,
biomimetic
nanocarriers
enhanced
biocompatibility.
AI-driven
utilize
machine
learning
algorithms
optimize
nanoparticle
properties,
drug
release
profiles
minimizing
off-target
effects.
Multifunctional
integrate
with
chemotherapy,
immunotherapy,
or
photothermal
synergistic
treatment
approaches
that
outcomes
reduce
resistance.
Biomimetic
nanocarriers,
including
exosome-mimicking
systems
cell-membrane-coated
nanoparticles,
improve
circulation
time,
evasion,
targeted
tumor
delivery.
These
collectively
precision,
efficiency,
therapies.
The
scope
novelty
lie
their
ability
overcome
primary
barriers
while
paving
way
clinically
viable
solutions.
provides
comprehensive
analysis
latest
developments
fabrication,
preclinical
studies,
assessments.
By
integrating
multifunctionality,
biomimicry,
holds
immense
potential
future
therapy.
Language: Английский