Gut microbiota from patients with mild COVID-19 cause alterations in mice that resemble post-COVID syndrome DOI Creative Commons
Viviani Mendes de Almeida, Daiane F. Engel, Mayra Fernanda Ricci

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: June 22, 2022

Abstract Background There is mounting evidence that SARS-CoV-2 targets tissues beyond the respiratory tract. Long-term sequelae after COVID-19 are frequent and of major concern. Prolonged virus detection in gut has been particularly intriguing. Of note, infection also disturbs microbiota composition, a finding linked with disease severity patients COVID-19. Here, we aimed to characterize functional role long-term consequences To this end, characterized from human subjects followed effects fecal transfer germ-free mice. Results The post-COVID (up 4 months initial positive test) revealed remarkable predominance Enterobacteriaceae strains multidrug-resistance phenotype compared healthy controls. After mice, animals receiving samples displayed higher lung inflammation increased susceptibility pulmonary caused by an antimicrobial resistant Klebsiella pneumoniae strain. These mice showed poorer cognitive performance associated expression TNF-α, reduced levels brain-derived neurotrophic factor-BDNF postsynaptic density protein-PSD-95 brain, as well alterations several biochemical pathways. were observed absence SARS-CoV-2, suggesting them. Consistent hypothesis, brain dysfunctions induced mouse model coronavirus partially prevented modulation via treatment commensal probiotic bacteria Bifidobacterium longum 51A. Conclusions Our results show prolonged impact persists even individuals have cleared virus. Increased resistance particular Moreover, loss functions impaired defense Altogether, our work emphasizes importance target for therapies help treat sequelae.

Language: Английский

Antibiotic Resistance during COVID-19: A Systematic Review DOI Open Access
Hadi J. Al Sulayyim,

Rohani Ismail,

Abdullah Al Hamid

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(19), P. 11931 - 11931

Published: Sept. 21, 2022

One of the public health issues faced worldwide is antibiotic resistance (AR). During novel coronavirus (COVID-19) pandemic, AR has increased. Since some studies have stated increased during COVID-19 and others otherwise, this study aimed to explore impact. Seven databases-PubMed, MEDLINE, EMBASE, Scopus, Cochrane, Web Science, CINAHL-were searched using related keywords identify relevant published from December 2019 May 2022, according PRISMA guidelines. Twenty-three were included in review, evidence showed that pandemic. The most commonly reported resistant Gram-negative bacteria was

Language: Английский

Citations

82
A parallel and silent emerging pandemic: Antimicrobial resistance (AMR) amid COVID-19 pandemic DOI Creative Commons
Suriya Rehman

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(4), P. 611 - 617

Published: Feb. 22, 2023

World is in the middle of pandemic (COVID-19), caused by SARS-COV-2 virus, which a significant global health crisis after Spanish influenza beginning 20th century. Progressive drastic steps have been enforced to minimize transmission disease. Likewise, current years, antimicrobial resistance (AMR) has referred as one potential perils economy and health; however, it now veiled under present pandemic. During pandemic, AMR available frontline antibiotics may prove fatal life threatening bacterial fungal infections during routine procedures like elective surgery, C-sections, etc. Currently, swift elevation multidrug-resistant organisms (MDROs), carbapenem-resistant New Delhi metallo-β-lactamase (NDM)-producing Acinetobacter baumannii, Enterobacterales, extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), multi-triazole-resistant Aspergillus fumigatus pan-echinocandin-resistant Candida glabrata seen. Thereupon, outbreak COVID-19 also offers some important ramification for developing drug resistance. This article aims highlights episodes aspects prevalence, impact management mismanagement crisis, hospital settings, community, environment, travel on

Language: Английский

Citations

79
Gut microbiota from patients with COVID-19 cause alterations in mice that resemble post-COVID symptoms DOI Creative Commons
Viviani Mendes de Almeida, Daiane F. Engel, Mayra Fernanda Ricci

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Sept. 5, 2023

Long-term sequelae of coronavirus disease (COVID)-19 are frequent and major concern. Severe acute respiratory syndrome 2 (SARS-CoV-2) infection affects the host gut microbiota, which is linked to severity in patients with COVID-19. Here, we report that microbiota post-COVID subjects had a remarkable predominance Enterobacteriaceae strains an antibiotic-resistant phenotype compared healthy controls. Additionally, short-chain fatty acid (SCFA) levels were reduced feces. Fecal transplantation from germ-free mice led lung inflammation worse outcomes during pulmonary by multidrug-resistant Klebsiella pneumoniae. transplanted also exhibited poor cognitive performance. Overall, show prolonged impacts SARS-CoV-2 on persist after have cleared virus. Together, these data demonstrate can directly contribute sequelae, suggesting it may be potential therapeutic target.

Language: Английский

Citations

40
Current Insights into Diagnosis, Prevention Strategies, Treatment, Therapeutic Targets, and Challenges of Monkeypox (Mpox) Infections in Human Populations DOI Creative Commons
Mitesh Patel, Mohd Adnan, Abdu Aldarhami

et al.

Life, Journal Year: 2023, Volume and Issue: 13(1), P. 249 - 249

Published: Jan. 16, 2023

In the wake of emergence and worldwide respread a viral infection called Monkeypox (Mpox), there is serious threat to health safety global population. This was endemic western central parts Africa, but has recently spread out this area various countries, including United Kingdom (UK), Portugal, Spain, States America (USA), Canada, Sweden, Belgium, Italy, Australia, Germany, France, Netherlands, Israel, Mexico. timely review focusing on recent findings developments in epidemiology, clinical features, therapeutic targets, diagnosis, prevention mechanisms, research challenges possible treatment for Mpox. To date (29 November 2022), have been around 81,225 reported cases most cases, illness mild; however, fatality rate ranging from 1 10%, which might be increased due associated complications and/or secondary infections. There real challenge diagnosis Mpox, since its symptoms are very similar those other infections, smallpox chickenpox. Generally, prevent/limit risk transmission detection isolation infected individuals, as well hand hygiene cleanliness, essential effective approaches control/combat infection. Nevertheless, updated information about Mpox different angles lacking. Thus, provides comprehensive illness, should highlight burden, pathogenicity, symptoms, measures emerging disease.

Language: Английский

Citations

30
The Hidden Cost of COVID-19: Focus on Antimicrobial Resistance in Bloodstream Infections DOI Creative Commons
Giulia Micheli,

Flavio Sangiorgi,

Francesca Catania

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(5), P. 1299 - 1299

Published: May 16, 2023

Antibiotic resistance is one of the greatest growing public health threats and a worldwide priority. According to WHO, drug-resistant diseases may cause 10 million deaths year by 2050 have substantial impact on global economy, driving up 24 people into poverty. The ongoing COVID-19 pandemic has exposed fallacies vulnerability healthcare systems worldwide, displacing resources from existing programs reducing funding for antimicrobial (AMR) fighting efforts. Moreover, as already seen other respiratory viruses, such flu, often associated with superinfections, prolonged hospital stays, increased ICU admissions, further aggravating disruption. These events are accompanied widespread antibiotic use, misuse, inappropriate compliance standard procedures potential long-term AMR. Still, COVID-19-related measures increasing personal environmental hygiene, social distancing, decreasing admissions could theoretically help AMR cause. However, several reports shown during pandemic. This narrative review focuses this “twindemic”, assessing current knowledge in era focus bloodstream infections provides insights lessons learned field that be applied stewardship initiatives.

Language: Английский

Citations

25
“Klebsiella pneumoniae: A Growing Threat in the Era of Antimicrobial Resistance” DOI Creative Commons

Sijo Asokan,

Thomas Prem Jacob,

Jenny Jacob

et al.

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100333 - 100333

Published: April 1, 2025

Language: Английский

Citations

2
Antimicrobial Potential of Pithecellobium dulce Seed Extract against Pathogenic Bacteria: In Silico and In Vitro Evaluation DOI Creative Commons
Abdu Aldarhami, Abdulrahman S. Bazaid, Abdullah S. Alhamed

et al.

BioMed Research International, Journal Year: 2023, Volume and Issue: 2023(1)

Published: Jan. 1, 2023

Clinical multi-drug-resistant bacteria continue to be a serious health problem. Plant-derived molecules are an important source of bioactive compounds counteract these pathogenic bacteria. In this paper, we studied the chemical composition methanol (80%) extract from Pithecellobium dulce seed (Hail, Saudi Arabia) and its ability inhibit growth clinically relevant Molecular docking analysis was performed predict best with low binding energy high affinity interact two Staphylococcus aureus receptors. Data showed that P. is rich D-turanose (55.82%), hexadecanoic acid (11.56%), indole-1-acetic (11.42%), inositol (5.78%), octadecanoic (4.36%). The obtained antibacterial activity towards tested clinical bacterial strains MIC values ranging 233 mg/mL for Acinetobacter baumannii 300 S. Escherichia coli. Turanose interaction has resulted in -7.4 -6.6 kcal/mol 1JIJ 2XCT macromolecules, while (-7.2 -5.4 kcal/mol) same Multiple identified desirable bioavailability properties indicating great potential therapeutic use human. Overall, current investigation highlights possible as valuable drug development against drug-resistant

Language: Английский

Citations

19
Pre- and post-COVID-19 antimicrobial resistance profile of bacterial pathogens, a comparative study in a tertiary hospital DOI Creative Commons
Mohammed Taleb, Abdelraouf A. Elmanama,

Alaa H Taleb

et al.

The Journal of Infection in Developing Countries, Journal Year: 2023, Volume and Issue: 17(05), P. 597 - 609

Published: May 31, 2023

Antimicrobial resistance (AMR) is a natural evolutionary process in bacteria that accelerated by selection pressure from the frequent and irrational use of antimicrobial drugs. This study aimed to determine variations AMR patterns priority bacterial pathogens at tertiary care hospital Gaza Strip during pre- post-COVID-19 pandemic.This retrospective observational pandemic period compared pre-COVID-19 period. Positive-bacterial culture data 2039 samples 1827 were obtained microbiology laboratory records. These analysed Chi square test using Statistical Package for Social Sciences (SPSS) Program.Gram-positive Gram-negative isolated. Escherichia coli was most prevalent both periods. The overall rate high. There statistically significant increase cloxacillin, erythromycin, cephalexin, co-trimoxazole amoxicillin/clavulanic acid also decrease cefuroxime, cefotaxime, gentamicin, doxycycline, rifampicin, vancomycin meropenem period.During COVID-19 pandemic, rates restricted noncommunity-used antimicrobials declined. However, there an used without medical prescription. Therefore, restriction on sale drugs community pharmacies prescription, stewardship awareness about dangers extensive antibiotics are recommended.

Language: Английский

Citations

15
Integration of immunoinformatics and cheminformatics to design and evaluate a multitope vaccine against Klebsiella pneumoniae and Pseudomonas aeruginosa coinfection DOI Creative Commons
Ahmed M. Gouda, Mohamed A. Soltan,

Khalid Abd-Elghany

et al.

Frontiers in Molecular Biosciences, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 14, 2023

Introduction:Klebsiella pneumoniae (K. pneumoniae) and Pseudomonas aeruginosa (P. aeruginosa) are the most common Gram-negative bacteria associated with pneumonia coinfecting same patient. Despite their high virulence, there is no effective vaccine against them. Methods: In current study, screening of several proteins from both pathogens highlighted FepA OmpK35 for K. in addition to HasR OprF P. as promising candidates epitope mapping. Those four were linked form a multitope vaccine, that was formulated suitable adjuvant, PADRE peptides finalize construct. The final vaccine's physicochemical features, antigenicity, toxicity, allergenicity, solubility evaluated use humans. Results: output computational analysis revealed designed construct has passed these assessments satisfactory scores where, last stage, we performed molecular docking study between potential immune receptors, TLR4 TLR2, showing affinitive targets preferentiality receptor protein. Validation studies proceeded through dynamics simulation, which estimated strong binding supported nomination putative solution coinfection. Here, describe approach design assessment our vaccine.

Language: Английский

Citations

14
Coinfections and Superinfections Associated with COVID-19 in Colombia: A Narrative Review DOI Creative Commons

Diana Dueñas,

Jorge Enrique Daza Arana, Yamil Liscano

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(7), P. 1336 - 1336

Published: July 20, 2023

The COVID-19 pandemic has had significant impacts on healthcare systems around the world, including in Latin America. In Colombia, there have been over 23,000 confirmed cases and 100 deaths since 2022, with highest number of occurring females males. elderly those comorbidities, such as arterial hypertension, diabetes mellitus, respiratory diseases, particularly affected. Coinfections other microorganisms, dengue virus, Klebsiella pneumoniae, Mycobacterium tuberculosis, also a factor increasing morbidity mortality rates patients. It is important for surveillance to be improved protocols established early detection management coinfections COVID-19. addition traditional treatments, alternatives zinc supplementation nanomedicine may potential fight against crucial consider social, labor, educational, psychological, emotional costs address issues poverty limited access potable water order better prepare future pandemics.

Language: Английский

Citations

12