Probiotics and Antimicrobial Proteins, Journal Year: 2023, Volume and Issue: 15(4), P. 1001 - 1013
Published: May 13, 2023
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129994 - 129994
Published: Feb. 6, 2024
Language: Английский
Citations
17
Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 81 - 81
Published: Jan. 3, 2025
Studies on the gastric microbiota associated with precancerous lesions remain limited. This study aimed to profile mucosal in patients Helicobacter pylori-negative lesions. Gastric samples were obtained from 67 H. patients, including those chronic gastritis (CG), intestinal metaplasia (IM), and dysplasia. The V3–V4 region of 16S rRNA gene was sequenced analyzed. No significant difference observed alpha or beta diversity among groups. However, a taxonomic analysis revealed enrichment Lautropia mirabilis depletion Limosilactobacillus reuteri, Solobacxterium moorei, Haemophilus haemolyticus, Duncaniella dubosii IM dysplasia groups compared CG group. Prevotella jejuni genus Parvimonas enriched A predictive functional ornithine degradation pathway groups, suggesting its role persistent inflammation showed an increased abundance oral microbes linked cancer reduction anti-inflammatory bacteria. These alterations might contribute inflammation, promoting carcinogenesis absence pylori infection.
Language: Английский
Citations
1
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 17, 2025
The gut microbiome plays a key role in human health, influencing various biological processes and disease outcomes. historical roots of probiotics are traced back to Nobel Laureate Élie Metchnikoff, who linked the longevity Bulgarian villagers their consumption sour milk fermented by Lactobacilli. His pioneering work led global recognition as beneficial supplements, now multibillion-dollar industry. Modern have been extensively studied for immunomodulatory effects. Limosilactobacillus reuteri (L. reuteri), widely used probiotic, has garnered significant attention its systemic immune-regulatory properties, particularly relation autoimmunity cancer. This review delves into L. modulating immune responses, with focus on impact diseases.
Language: Английский
Citations
1
Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
Language: Английский
Citations
1
ACS Nano, Journal Year: 2024, Volume and Issue: 18(25), P. 16297 - 16311
Published: June 13, 2024
While mesalamine, a 5-aminosalicylic acid (5-ASA), is pivotal in the management of inflammatory bowel disease (IBD) through both step-up and top-down approaches clinical settings, its widespread utilization limited by low bioavailability at desired site action due to rapid extensive absorption upper gastrointestinal (GI) tract. Addressing mesalamine's pharmacokinetic challenges, here, we introduce nanoassemblies composed exclusively mesalamine prodrug that pairs 5-ASA with mucoadhesive cathepsin B-cleavable peptide. In an IBD model, orally administered demonstrate enhanced accumulation sustained retention GI tract their properties epithelial permeability (eEPR) effect. This enables efficient uptake intestinal pro-inflammatory macrophages expressing high B, triggering burst release 5-ASA. cascade fosters polarization toward M2 macrophage phenotype, diminishes responses, simultaneously facilitates delivery active agents adjacent cells. Therefore, show outstanding therapeutic efficacy inhibiting local inflammation contribute suppressing systemic restoring damaged barriers. Collectively, this study highlights promising role enhancing targeted drug delivery, potentially broadening use managing IBD.
Language: Английский
Citations
8
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(17), P. 9880 - 9892
Published: April 22, 2024
Limosilactobacillus reuteri (L. reuteri) is an efficacious probiotic that could reduce inflammation and prevent metabolic disorders. Here, we innovatively found Polygonatum kingianum polysaccharides (PKP) promoted proliferation increased stability of L. WX-94 (a strain showing anti-inflammation potentials) in simulated digestive fluids vitro. PKP was composed galactose, glucose, mannose, arabinose. The cell-free supernatant extracted from cultured with ABTS•+, DPPH•, FRAP scavenging capacities compared the medium without metabolites health-promoting activities, e.g., 3-phenyllactic acid, indole-3-lactic indole-3-carbinol, propionic acid. Moreover, enhanced alleviating effects heat-inactivated on high-fat-high-sucrose-induced liver injury rats via reducing regulating expressions protein genes involved fatty acid metabolism (such as HIF1-α, FAβO, CPT1, AMPK) profiles liver. Such benefits correlated its prominent enriching Lactobacillus short-chain acids while Dubosiella, Fusicatenilacter, Helicobacter, Oscillospira. Our work provides novel insights into property emphasizes great potential inactivated contracting unhealthy diet-induced dysfunctions gut dysbacteriosis.
Language: Английский
Citations
6
Nature Cancer, Journal Year: 2023, Volume and Issue: 4(8), P. 1083 - 1094
Published: July 31, 2023
Language: Английский
Citations
15
Food & Function, Journal Year: 2024, Volume and Issue: 15(3), P. 1340 - 1354
Published: Jan. 1, 2024
The cholesterol-lowering effect of lactic acid bacteria with high activity bile salt hydrolase (BSH) is unclear. We believe that distinguishing BSH substrate specificity necessary to study the various enzymes. engineered a mutant enzyme recombinant strain named F67A, which exclusively hydrolyzes taurocholic (TCA) using site-directed mutagenesis, and previously lab-constructed strain, YB81 glycocholic (GCA). also constructed NB5462, carries empty pSIP411 plasmid was used as blank control strain. intestinal flora in pseudo-germ-free (PGF) mice were eliminated
Language: Английский
Citations
4
Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21
Published: June 26, 2024
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Citations
4
Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
ABSTRACT Chickens are one of the most economically important poultry species, and their egg-laying performance is a crucial economic trait. The intestinal microbiome plays significant role in performance. To clarify diversity chicken microbiota its connection to performance, this study utilized 16S rRNA sequencing technology characterize microbiomes 101 chickens from 13 breeds with varying levels egg production. results reveal differences gut structure among groups production levels. High egg-producing showed significantly higher abundances Firmicutes , Proteobacteria Lactobacillus while low displayed greater microbial α-diversity more complex community structures. These influence key physiological functions, including nutrient absorption hormone regulation through metabolic pathways, directly affect medium partially overlapped on principal coordinates analysis plot, whereas high-production group was distinctly separate. This provides scientific basis data for selecting probiotics related high chickens. IMPORTANCE elucidates critical chickens, indicator industry. By employing sequencing, we uncovered distinct profiles associated exhibit abundance specific bacterial taxa, such as which linked enhanced efficiency. Conversely, lower display diversity, suggesting but less efficient ecosystem. Our findings provide valuable insights into relationship between production, offering foundation selection that could potentially improve research not only advances our understanding avian microbiology also has practical implications optimizing farming practices enhancing outcomes.
Language: Английский
Citations
0