Pharmacological Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107672 - 107672
Published: Feb. 1, 2025
The
characteristic
of
cardiorenal
syndrome
(CRS)
is
simultaneous
damage
to
both
the
heart
and
kidneys.
CRS
has
caused
a
heavy
burden
mortality
incidence
rates
worldwide.
regulation
host
microbiota
metabolism
that
triggers
kidney
an
emerging
research
field
promotes
new
perspective
on
cardiovascular
risk.
We
summarize
current
studies
from
bench
bedside
gut
microbiota-derived
metabolites
better
understand
in
context
metabolites.
focused
involvement
pathophysiology
CRS,
including
lipid
cholesterol
disorders,
coagulation
abnormalities
platelet
aggregation,
oxidative
stress,
endothelial
dysfunction,
inflammation,
mitochondrial
energy
vascular
calcification
renal
fibrosis,
as
well
therapeutic
approaches
targeting
which
provides
innovative
treatment
approach
for
improve
patient
prognosis
overall
quality
life.
Future Microbiology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 13
Published: Feb. 27, 2025
Kawasaki
disease
(KD)
is
an
acute
systemic
immune
vasculitis
with
predominant
involvement
of
the
medium
and
small
arteries.
It
mostly
affects
pediatric
patients,
representing
most
common
form
in
children
less
than
5
years
old.
Numerous
diseases,
especially
those
related
to
system,
have
established
links
intestinal
flora.
Recent
studies
investigated
flora
changes
throughout
management
KD.
There
was
gut
microbiota
dysbiosis
KD
at
phase,
particularly
downregulation
short-chain
fat
acids-producing
over-proliferation
opportunistic
pathogens.
The
relationship
between
response
therapies
individuals
specific
remains
uncertain.
Targeted
microbial
supplements
dietary
regulation
may
serve
as
potential
measures
alleviate
complications
thus
improve
prognosis.
This
review
provides
overview
current
understanding
interplay
Furthermore,
it
discusses
possibility
altering
reinstate
a
healthy
condition.
