A Systematic Review of Denture Stomatitis: Predisposing Factors, Clinical Features, Etiology, and Global Candida spp. Distribution

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(5), P. 328 - 328

Published: April 30, 2024

Denture stomatitis (DS) is a very common disease in wearers of removable complete and partial dentures with worldwide prevalence the range 20–67%. Both industrially developed impoverished nations are affected by illness. DS often associated ill-fitting or fungal infection Candida spp. normally found oral cavity microbiota, but it can be harmful to health elderly people underlying diseases. Therefore, purpose present study offer most recent information about epidemiology, etiology, global distribution species through systematic review. Several databases, including Medline, Web Science, Scopus, were used conduct an extensive search literature published previous 20 years. The selection studies was performed two authors. extracted data as follows: author, year publication, country, sample, frequency DS, method diagnosing stomatitis, Candida, risk factors, etiology disease. JBI Critical appraisal tools assess quality studies. Eventually, twenty-eight included Twenty-one investigated while seven examined colonization patients using dentures. results show that main causes include type dentures, continuous wearing formation biofilm, which facilitated poor dental hygiene. Additionally, have pinpointed significance salivary flow, saliva composition, pH. findings current review indicate crucial monitor denture for appearance especially whose immunity has been impaired due systemic condition. Finally, frequent follow-ups should clinical examination microbial swabs palatal mucosa mucosal surface denture.

Language: Английский

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The effect of photobiomodulation on oral microbiota dysbiosis: A literature review

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 104525 - 104525

Published: Feb. 1, 2025

Language: Английский

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Denture stomatitis: Treatment with antimicrobial drugs or antifungal gels? A systematic review of clinical trials

Journal of Prosthetic Dentistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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Living together: The role of Candida albicans in the formation of polymicrobial biofilms in the oral cavity

Yeast, Journal Year: 2023, Volume and Issue: 40(8), P. 303 - 317

Published: May 16, 2023

The oral cavity of humans is colonized by diversity microbial community, although dominated bacteria, it also constituted a low number fungi, often represented Candida albicans. Although in the vast minority, this usually commensal fungus under certain conditions host (e.g., immunosuppression or antibiotic therapy), can transform into an invasive pathogen that adheres to mucous membranes and medical dental devices, causing mucosal infections. This transformation correlated with changes cell morphology from yeast-like cells hyphae supported numerous virulence factors exposed C. albicans at site infection, such as multifunctional adhesins, degradative enzymes, toxin. All them affect surrounding proteins, leading their destruction. However, interact different bacterial species its filamentous form may produce biofilms-the elaborated consortia microorganisms, present increased ability colonization resistance antimicrobial agents. In review, we highlight modification infectious potential contact species, consider mutual bacterial-fungal relationships, involving cooperation, competition, antagonism, lead increase propagation infection. mycofilm excellent hiding place for especially those prefer oxygen availability, where during co-existence avoid recognition elimination action. these identified mainly vitro studies, are modified depending on complexity dominance vivo.

Language: Английский

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Adhesion of Candida Albicans to digital versus conventional acrylic resins: a systematic review and meta-analysis

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 4, 2024

Abstract Background The present systematic review and meta-analysis investigated the available evidence about adherence of Candida Albicans to digitally-fabricated acrylic resins (both milled 3D-printed) compared conventional heat-polymerized . Methods This study followed guidelines Preferred Reporting Items for Systematic Review Meta-analyses (PRISMA). A comprehensive search online databases/search tools (Web Science, Scopus, PubMed, Ovid, Google Scholar) was conducted all relevant studies published up until May 29, 2023. Only in-vitro comparing albicans digital were included. quantitative analyses performed using RevMan v5.3 software. Results Fourteen included, 11 which meta-analyzed based on Colony Forming Unit (CFU) Optical Density (OD) outcome measures. pooled data revealed significantly lower candida colonization conventionally-fabricated resin materials (MD = − 0.36; 95%CI 0.69, 0.03; P 0.03 MD 0.04; 0.06, 0.01; 0.0008; as measured by CFU OD respectively). However, no differences found in adhesion between 3D-printed (CFU: 0.11, OD: 0.20). Conclusion suggests that is less likely adhere ones.

Language: Английский

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Lung antimicrobial proteins and peptides: From host defense to therapeutic strategies

Physiological Reviews, Journal Year: 2024, Volume and Issue: 104(4), P. 1643 - 1677

Published: July 25, 2024

Representing severe morbidity and mortality globally, respiratory infections associated with chronic diseases, including complicated pneumonia, asthma, interstitial lung disease, obstructive pulmonary are a major public health concern. Lung the prevention of disease rely on mechanisms airway surface fluid secretion, mucociliary clearance, adequate immune response to eradicate inhaled pathogens particulate matter from environment. The antimicrobial proteins peptides contribute maintaining an milieu in human lungs eliminate prevent them causing diseases. predominant molecules environment include α- β-defensins cathelicidins, among numerous other host defense antibiofilm activity such as PLUNC (palate, lung, nasal epithelium clone) family proteins, elafin, collectins, lactoferrin, lysozymes, mucins, secretory leukocyte proteinase inhibitor, surfactant SP-A SP-D, RNases. It has been demonstrated that changes molecule expression levels regulating inflammation, potentiating exacerbations, pathological changes, modifications severity. Antimicrobial also display roles both anticancer tumorigenic effects. promising alternative therapeutics for treating preventing multidrug-resistant bacterial therapies.

Language: Английский

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Effect of nanogold incorporation into polymethyl methacrylate denture bases on microbial activity in implant-retained mandibular overdentures

International Journal of Implant Dentistry, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 6, 2025

Abstract Purpose In this randomized clinical trial, we examined the incorporation of nanogold particles into polymethyl methacrylate denture bases and compared these modified with conventional ones in mandibular implant-retained overdentures, focusing on microbiological growth adhesion characteristics. Methods study, twenty-two male patients who were completely edentulous participated a rehabilitation program involving overdentures retained by two dental implants placed canine area. The subjects categorized equal groups, each comprising eleven patients. Group I received fabricated from acrylic bases, whereas II that had undergone treatment. Microbial colonization evaluated around implant’s necks fitting surface patient’s dentures. Three types bacteria studied: Candida albicans, Escherichia coli, Streptococcus mutans. mean difference counts before was inserted after two, four, six months has been calculated analyzed statistically. Results Regarding colony count (log 10 CFUs/mmL), there significant between research groups. significantly lower values measured at 2, 4, 6 for mutans, respectively, than group I. Conclusion addition gold nanoparticles to PMMA greater benefit inhibiting microbial resin bases.

Language: Английский

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Effect of polishing methods on Candida albicans adhesion and contributing factors in heat-cured acrylic dentures: an in-vitro comparative study

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 8, 2025

Heat-polymerized acrylic resin is widely used in prosthodontics due to its various advantages. However, susceptibility microbial colonization, influenced by surface properties such as roughness, water sorption, and free energy, poses challenges maintaining oral health. Microbial adhesion, particularly of Candida albicans, plays a significant role the overall load on denture surface, predisposing several health related complications. While polishing techniques improve smoothness, their effects sorption which are critical remain understudied. This study explores impact Mechanical Polishing (MP) Chemical (CP) methods these potential reduce albicans adhesion. Twenty-four square samples heat-cured were fabricated divided into two groups 12 for MP CP respectively. Surface roughness (Ra) was measured using profilometer. Scanning Electron Microscopy (SEM) analysis conducted polished unpolished specimens. Water assessed through weekly weighing, energy determined goniometer. identification done Dichloran Rose-Bengal Chloramphenicol (DRBC) agar confirmation achieved microscopy growth selective media. Adherence viable assays performed both non-polished Statistical SPSS (Version 24.0). Mann-Whitney U test compared initial adherence between groups. Linear regression examined influence factors adherence. did not significantly differ methods. resulted reduced lower decreased adhesion MP. A negative association observed Both desired level smoothness. demonstrated superior performance reducing suggests practical benefits clinical settings, intaglio surfaces where impractical.

Language: Английский

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A Novel Approach of Administering Cranberry Extract Into 3D-Printed Denture Bases for the Prevention of Denture-Induced Stomatitis: An Observational Study

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Background: Complete dentures play an important role in restoring oral function and aesthetics, yet they may contribute to denture stomatitis, necessitating improved materials hygiene practices. Cranberry extract, known for its antifungal properties, presents a promising avenue preventing stomatitis when incorporated into novel materials. Aims objectives: This research aimed assess the efficiency of cranberry extract-infused stereolithography (SLA) 3D-printable resins denture-induced compare their mechanical properties with conventional heat-cured base polymers. Materials methods: Fifteen patients aged 45 60 completely edentulous maxillary mandibular arches received two sets dentures: control made from heat-activated polymethyl methacrylate (PMMA) treatment cranberry-infused 3D-printed resin. Candidal colony-forming units (CFUs) confocal microscopy were used biofilm formation on 30 samples. For evaluation samples each group, flexural strength fracture toughness examined both test groups. Results: Significantly fewer CFUs observed compared PMMA at 104 concentrations (p=0.03). Biofilm thickness was significantly lower (p=0.039), but volume fraction exhibited no discernible change (p>0.05). Surface coverage reduced (p=0.028). Flexural higher (124.25±2.67 MPa) (109.76±9.35 MPa), statistically significant difference. Fracture also (1.60±0.12) (1.38±0.95) Conclusion: Cranberry-infused demonstrate promise dropping Candida adhesion formation, potentially lowering risk stomatitis. Moreover, these exhibit superior polymers, suggesting potential alternative prosthodontic applications.

Language: Английский

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Candida Infections: The Role of Saliva in Oral Health—A Narrative Review

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 717 - 717

Published: March 23, 2025

Candida species, particularly albicans, are causative agents of oral infections to which immunocompromised patients especially susceptible. Reduced saliva flow (xerostomia) can lead overgrowth, as contains antibacterial components such histatins and β-defensins that inhibit fungal growth adhesion the mucosa. adheres host tissues, forms biofilms, secretes enzymes required for tissue invasion immune evasion. Secretory asparaginyl proteinases (Saps) candidalysin, a cytolytic peptide toxin, vital virulence, agglutinin-like sequence (Als) proteins crucial adhesion, invasion, biofilm formation. C. albicans is risk factor dental caries may increase periodontal disease virulence when it coexists with Porphyromonas gingivalis. have been suggested heighten cancer based on relationship between species squamous cell carcinoma (OSCC) or potentially malignant disorder (OPMD). Meanwhile, β-glucan in wall has antitumor effects. In addition, biofilms protect viruses herpesviruses coxsackieviruses. Understanding intricate interactions responses, coexisting microbial communities essential developing preventive therapeutic strategies against infections, individuals.

Language: Английский

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