Supportive Care in Cancer,
Journal Year:
2024,
Volume and Issue:
32(8)
Published: July 30, 2024
Advances
in
the
treatment
of
cancer
have
significantly
improved
mortality
rates;
however,
this
has
come
at
a
cost,
with
many
treatments
still
limited
by
their
toxic
side
effects.
Mucositis
both
mouth
and
gastrointestinal
tract
is
common
following
anti-cancer
agents,
manifesting
as
ulcerative
lesions
associated
symptoms
throughout
alimentary
tract.
The
pathogenesis
mucositis
was
first
defined
2004
Sonis,
almost
20
years
on,
model
continues
to
be
updated
reflecting
ongoing
research
initiatives
more
sophisticated
analytical
techniques.
most
recent
update,
published
Multinational
Association
for
Supportive
Care
Cancer
International
Society
Oral
Oncology
(MASCC/ISOO),
highlights
numerous
co-occurring
events
that
underpin
development.
Most
notably,
role
ecosystem
microorganisms
reside
(the
oral
gut
microbiota)
explored,
building
on
initial
concepts
proposed
Sonis.
However,
questions
remain
regarding
true
causal
contribution
microbiota
metabolome.
This
review
aims
provide
an
overview
rapidly
evolving
area,
synthesizing
current
evidence
microbiota's
development
progression,
highlighting
(i)
components
5-phase
where
microbiome
may
involved,
(ii)
methodological
challenges
hindered
advances
(iii)
opportunities
intervention.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 2, 2024
Abstract
In
consideration
of
the
important
influence
gut
microbiota
on
colorectal
cancer
(CRC)
development
and
host
immune
system,
regulating
intestinal
environment
can
be
an
assisting
approach
to
CRC
treatment.
To
remodel
tumor
microenvironment,
anti‐CRC
molecular
targeting
drug
regorafenib
(REG)‐encapsulating
nanoparticle
(UIRN)
is
constructed
with
amphiphilic
inulin‐ursodeoxycholic
acid
conjugate.
UIRN
increases
intra‐tumoral
concentration
accumulation
time
REG.
CT26
tumor‐bearing
mouse
model,
relative
abundance
probiotics
short‐chain
fatty
concentrations
in
colon
are
upregulated
after
treatment
UIRN,
decreased
proportion
pro‐tumoral
bacteria.
Combining
modulation
function
REG
induce
polarization
tumor‐associated
macrophages
toward
M1‐type,
conquers
immunosuppression
enhances
anti‐tumor
immunity.
not
only
efficiently
controls
progression
alone
but
also
exhibits
adjuvant
effects
chemotherapy
immunotherapy
agents.
The
microbiota‐regulating
tumor‐suppressing
functions
work
colitis‐associated
model.
With
good
biosafety,
displays
hopeful
application
prospects
therapy.
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(12), P. 3117 - 3117
Published: Dec. 2, 2022
The
gastrointestinal
(GI)
tract
is
one
of
the
most
studied
compartments
human
body
as
it
hosts
largest
microbial
community
including
trillions
germs.
relationship
between
and
its
associated
flora
complex,
microbiome
plays
an
important
role
in
nutrition,
metabolism
immune
function.
With
a
dynamic
composition,
influenced
by
many
intrinsic
extrinsic
factors,
there
equilibrium
maintained
composition
GI
microbiota,
translated
“eubiosis”.
Any
disruption
microbiota
leads
to
development
different
local
systemic
diseases.
This
article
reviews
microbiome’s
function
healthy
individuals
well
involvement
pathogenesis
digestive
disorders.
It
also
highlights
possibility
consider
manipulation
therapeutic
option
when
treating
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9422 - 9422
Published: Aug. 30, 2024
The
gut
barrier
is
essential
for
protection
against
pathogens
and
maintaining
homeostasis.
Macrophages
are
key
players
in
the
immune
system,
indispensable
intestinal
health,
contribute
to
defense
repair
mechanisms.
Understanding
multifaceted
roles
of
macrophages
can
provide
critical
insights
into
restoring
gastrointestinal
(GI)
health.
This
review
explores
role
function
their
contribution
post-inflammatory
post-infectious
responses
gut.
significantly
integrity
through
epithelial
repair,
modulation,
interactions
with
microbiota.
They
demonstrate
active
plasticity
by
switching
phenotypes
resolve
inflammation,
facilitate
tissue
regulate
microbial
populations
following
an
infection
or
inflammation.
In
addition,
tissue-resident
(M2)
infiltration
(M1)
convert
each
other
problems
such
as
IBS
IBD
via
major
signaling
pathways
mediated
NF-κB,
JAK/STAT,
PI3K/AKT,
MAPK,
Toll-like
receptors,
specific
microRNAs
miR-155,
miR-29,
miR-146a,
miR-199,
which
may
be
good
targets
new
therapeutic
approaches.
Future
research
should
focus
on
elucidating
detailed
molecular
mechanisms
developing
personalized
approaches
fully
harness
potential
maintain
restore
permeability
Supportive Care in Cancer,
Journal Year:
2024,
Volume and Issue:
32(8)
Published: July 30, 2024
Advances
in
the
treatment
of
cancer
have
significantly
improved
mortality
rates;
however,
this
has
come
at
a
cost,
with
many
treatments
still
limited
by
their
toxic
side
effects.
Mucositis
both
mouth
and
gastrointestinal
tract
is
common
following
anti-cancer
agents,
manifesting
as
ulcerative
lesions
associated
symptoms
throughout
alimentary
tract.
The
pathogenesis
mucositis
was
first
defined
2004
Sonis,
almost
20
years
on,
model
continues
to
be
updated
reflecting
ongoing
research
initiatives
more
sophisticated
analytical
techniques.
most
recent
update,
published
Multinational
Association
for
Supportive
Care
Cancer
International
Society
Oral
Oncology
(MASCC/ISOO),
highlights
numerous
co-occurring
events
that
underpin
development.
Most
notably,
role
ecosystem
microorganisms
reside
(the
oral
gut
microbiota)
explored,
building
on
initial
concepts
proposed
Sonis.
However,
questions
remain
regarding
true
causal
contribution
microbiota
metabolome.
This
review
aims
provide
an
overview
rapidly
evolving
area,
synthesizing
current
evidence
microbiota's
development
progression,
highlighting
(i)
components
5-phase
where
microbiome
may
involved,
(ii)
methodological
challenges
hindered
advances
(iii)
opportunities
intervention.
