Bioactive Molecules from Marine Diatoms and Their Value for the Nutraceutical Industry

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 464 - 464

Published: Jan. 16, 2023

The search for novel sources of nutrients is among the basic goals achievement sustainable progress. In this context, microalgae are relevant organisms, being rich in high-value compounds and able to grow open ponds or photobioreactors, thus enabling profitable exploitation aquatic resources. Microalgae, a huge taxon containing photosynthetic microorganisms living freshwater, as well brackish marine waters, typically unicellular eukaryotic, include green algae (Chlorophyceae), red (Rhodophyceae), brown (Phaeophyceae) diatoms (Bacillariophyceae). recent decades, have been considered most humans with respect other microalgae. This review focuses on studies exploring their bio-pharmacological activities when human disease prevention and/or treatment. addition, we extracts (or purified compounds) specific nutraceutical applications.

Language: Английский

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Nanoparticles from Microalgae and Their Biomedical Applications

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(6), P. 352 - 352

Published: June 7, 2023

Over the years, microalgae have been a source of useful compounds mainly used as food and dietary supplements. Recently, metabolites that can participate in synthesis several nanoparticles through inexpensive environmentally friendly routes alternative to chemical synthesis. Notably, occurrence global health threats focused attention on application medicinal field. In this review, we report influence secondary from marine freshwater cyanobacteria were applied therapeutics. addition, use isolated surface combat diseases has also addressed. Although studies proven beneficial effect high-value bioproducts their potential medicine, there is still room for understanding exact role human body translating lab-based research into clinical trials.

Language: Английский

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Enhanced Expression of p53 and Suppression of PI3K/Akt/mTOR by Three Red Sea Algal Extracts: Insights on Their Composition by LC-MS-Based Metabolic Profiling and Molecular Networking

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(7), P. 404 - 404

Published: July 17, 2023

Brown algae comprise up to 2000 species with wide dissemination in temperate zones. A comprehensive untargeted metabolic profiling guided by molecular networking of three uninvestigated Red-Sea-derived brown algae, namely Sirophysalis trinodis, Polycladia myrica, and Turbinaria triquetra, led the identification over 115 metabolites categorized as glycerolipids, fatty acids, sterol lipids, sphingolipids, phospholipids. The exhibited low-to-moderate antioxidant capacity using DPPH ABTS assays. Preliminary vitro antiproliferative studies showed that algal extracts displayed high cytotoxic activity against a panel cancer cell lines. most potent was recorded MCF-7 IC50 values 51.37 ± 1.19, 63.44 1.13, 59.70 1.22 µg/mL for S. P. T. respectively. cytotoxicity selective without showing notable effects on proliferation normal human WISH cells. Morphological revealed caused shrinkage, increased cellular debris, triggered detachment, rounding, cytoplasmic condensation Mechanistic investigations flow cytometry, qPCR, Western blot induced apoptosis, initiated cycle arrest sub-G0/G1 phase, inhibited cells via increasing mRNA protein expression p53, while reducing PI3K, Akt, mTOR.

Language: Английский

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A potential paradigm in CRISPR/Cas systems delivery: at the crossroad of microalgal gene editing and algal-mediated nanoparticles

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Oct. 10, 2023

Abstract Microalgae as the photosynthetic organisms offer enormous promise in a variety of industries, such generation high-value byproducts, biofuels, pharmaceuticals, environmental remediation, and others. With rapid advancement gene editing technology, CRISPR/Cas system has evolved into an effective tool that revolutionised genetic engineering microalgae due to its robustness, high target specificity, programmability. However, lack robust delivery system, efficacy is significantly impaired, limiting application microalgae. Nanomaterials have become potential platform for systems their advantages precise targeting, stability, safety, improved immune system. Notably, algal-mediated nanoparticles (AMNPs), especially microalgae-derived nanoparticles, are appealing sustainable because biocompatibility low toxicity homologous relationship. In addition, living demonstrated regulated distribution specified areas biohybrid microrobots. This review extensively summarised uses recent developments nanoparticle-based systems. A systematic description properties AMNPs, microrobots also been discussed. Finally, this highlights challenges future research directions development gene-edited Graphical

Language: Английский

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Algal lipids: A review on current status and future prospects in food processing

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(1)

Published: Jan. 1, 2025

Abstract The consumer demand for functional foods derived from natural sources has been enhanced due to health‐promoting effects. Algae are widely available globally as a sustainable source of proteins, lipids, and carbohydrates. Algal lipids underexplored that exhibit several nutraceutical effects applications in fortification, cosmetics, pharmaceuticals. Both macro‐ microalgae composed high‐quality lipids. These latter involve polar nonpolar essential fatty acids. Therefore, this review aimed bring out knowledge on the chemistry various isolated identified micro‐ macroalgae. Further, their extraction using traditional thermal (solid–liquid, liquid–liquid) advanced nonthermal (supercritical fluid, microwave‐, ultrasound‐, enzyme‐assisted) techniques explored. Along with this, bioactivities algal have discussed. This study explored advancing food processing technologies contribute positively environmental sustainability global health, line United Nations Sustainable Development GroupUnited Group UNSDGs.

Language: Английский

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Preclinical and clinical applications of algal biomedical products

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 89 - 111

Published: Jan. 1, 2025

Language: Английский

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Carbon capture by algae for sustainable product generation

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 57 - 68

Published: Jan. 1, 2025

Language: Английский

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Microalgae-Based Functional Foods: A Blue-Green Revolution in Sustainable Nutrition and Health

Applied Microbiology, Journal Year: 2025, Volume and Issue: 5(2), P. 39 - 39

Published: April 23, 2025

The projected global population of 9.22 billion by 2075 necessitates sustainable food sources that provide health benefits beyond essential nutrition, as the relationship between biochemistry and human well-being is becoming increasingly significant. Microalgae are simple microscopic organisms rich in various bioactive compounds, such pigments, vitamins, polyunsaturated fatty acids, polysaccharides, peptides, polyphenols, which can be used to develop novel foods with potential benefits. Bioactive substances offer numerous benefits, including anti-inflammatory, anticancer, antioxidant, anti-obesity, heart-protective effects. However, incorporating microalgal biomass into functional products presents several challenges, species diversity, fluctuations production, factors affecting cultivation, suboptimal bioprocessing methods, inconclusive evidence regarding bioavailability safety, undesirable flavors aromas formulations. Despite these significant opportunities exist for future development microalgae-derived products. Extensive investigations overcome challenges enable large-scale commercialization nutritious microalgae-based This review aims examine microalgae natural ingredients explore limiting their industrial acceptance utilization, assess safety issues associated consumption.

Language: Английский

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The Plethora of Microbes with Anti-Inflammatory Activities

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2980 - 2980

Published: March 4, 2024

Inflammation, which has important functions in human defense systems and maintaining the dynamic homeostasis of body, become a major risk factor for progression many chronic diseases. Although applied medical products alleviate general status, they still exert adverse effects long term. For this reason, solution should be sought more harmless affordable agents. Microorganisms offer wide range active substances with anti-inflammatory properties. They confer advantages such as their renewable inexhaustible nature. This review aims to provide most recent updates on microorganisms different types genera, being carriers activity.

Language: Английский

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Antibacterial Activity of Bioactive Compounds Extracted from the Egyptian Untapped Green Alga Rhizoclonium hieroglyphicum

Water, Journal Year: 2023, Volume and Issue: 15(11), P. 2030 - 2030

Published: May 26, 2023

Finding alternative powerful antibacterial drugs of natural origins is, today, a crucial prerequisite due to the resistance some bacterial strains commercial and widely-used medications. Algae are characterized by their bioactive constituents have wide spectrum biotechnological aspects, particularly implications. During this study, four concentrations (5, 10, 20, 40 mg mL–1) Egyptian untapped green microalga Rhizoclonium hieroglyphicum (Chlorophyta) were prepared using polar solvents ethanol, methanol, acetone. The activity above-mentioned extracts was assessed, agar disc diffusion technique against three pathogenic bacteria, Staphylococcus aureus ATCC 6538, Escherichia coli 8739, Pseudomonas aeruginosa 9027, which compared standard antibiotics. minimal inhibitory (MICs) also assessed determined broth dilution assay. Our findings revealed that R. ethanolic extract exhibited most potent effect its MICs values 0.533, 2.25, 5.34 mL–1 P. aeruginosa, E. coli, S. aureus, respectively. A gas chromatography–mass spectrometry (GC–MS) approach crude uncovered 30 different constituents, mainly including long-chain polyunsaturated saturated fatty acids such as myristic (C14:0), palmitic (C16:0), stearic (C18:0), α-linolenic (C18:3; ω–3), oleic (C18:1, ω–9) acids, synergistically make action. mechanism action these discussed. Conclusively, could be good candidate for production development promising agents.

Language: Английский

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