Microbiota and Autism: A Review on Oral and Gut Microbiome Analysis Through 16S rRNA Sequencing

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2686 - 2686

Published: Nov. 25, 2024

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with multifactorial etiologies, including genetic, environmental, and microbiological factors. In recent years, increasing attention has been given to the role of gut microbiota in ASD. Emerging evidence suggests that dysbiosis may influence central nervous system through gut-brain axis, potentially impacting behavior neurodevelopment. The use 16S rRNA gene sequencing become pivotal tool profiling microbial communities associated ASD, offering valuable insights into bacterial diversity, composition, potential functional roles. This review aims provide comprehensive analysis current findings on relationship between oral particular focus studies utilizing sequencing. We will explore how microbiome alterations contribute ASD pathophysiology, discuss limitations existing research, propose future directions for integration diagnostics treatment strategies. These underscore modulating symptoms. data suggest specific taxa are consistently altered which have implications understanding axis its

Language: Английский

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Syndrome Pattern Recognition Method Using Sensed Patient Data for Neurodegenerative Disease Progression Identification

Diagnostics, Journal Year: 2023, Volume and Issue: 13(5), P. 887 - 887

Published: Feb. 26, 2023

Neurodegenerative diseases are a group of conditions that involve the progressive loss function neurons in brain and spinal cord. These can result wide range symptoms, such as difficulty with movement, speech, cognition. The causes neurodegenerative poorly understood, but many factors believed to contribute development these conditions. most important risk include ageing, genetics, abnormal medical conditions, toxins, environmental exposures. A slow decline visible cognitive functions characterises progression diseases. If left unattended or unnoticed, disease serious issues cessation motor even paralysis. Therefore, early recognition is becoming increasingly modern healthcare. Many sophisticated artificial intelligence technologies incorporated into healthcare systems for This research article introduces Syndrome-dependent Pattern Recognition Method detection monitoring proposed method determines variance between normal intrinsic neural connectivity data. observed data combined previous healthy examination identify variance. In this analysis, deep recurrent learning exploited by tuning analysis layer based on suppressed identifying patterns analysis. from different recurrently used train model maximising accuracy. achieves 16.77% high accuracy, 10.55% precision, 7.69% pattern verification. It reduces verification time 12.08% 12.02%, respectively.

Language: Английский

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Epidermal microorganisms contributed to the toxic mechanism of nZVI and TCEP in earthworms by robbing metal elements and nutrients

Eco-Environment & Health, Journal Year: 2023, Volume and Issue: 3(1), P. 80 - 88

Published: Nov. 29, 2023

Disrupting effects of pollutants on symbiotic microbiota have been regarded as an important mechanism host toxicity, with most current research focusing the intestinal microbiota. In fact, epidermal microbiota, which participates in nutrient exchange between hosts and environments, could play a crucial role toxicity via community changes. To compare contributions microorganisms to this study designed single combined scenarios soil contamination [nano zero-valent iron tris (2-chloroethyl) phosphate], revealed coupling mechanisms intestinal/epidermal bacterial communities earthworm toxicological endpoints. Microbiome analysis showed that 15% microbes were highly correlated endpoints, compared 45% showing similar correlation. Functional comparisons key species epidermis mainly heterotrophic genetic abilities utilize metal elements carbohydrate nutrients. Further verifications demonstrated when facing co-contamination nZVI TCEP, certain became dominant consumed zinc, copper, manganese along saccharides amino acids, may be responsible for nutritional deficiencies earthworms. The findings can enrich understanding relationship highlighting importance resistance environmental pollution.

Language: Английский

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Gut Microbiome and Psychiatric Disorders

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 527 - 558

Published: Jan. 1, 2024

Language: Английский

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Human microbiome and neuro-developmental disorders

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 133 - 150

Published: Oct. 25, 2024

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