Diabetes Mellitus and Pneumococcal Pneumonia

Diagnostics, Journal Year: 2024, Volume and Issue: 14(8), P. 859 - 859

Published: April 22, 2024

Currently, there are more than 500 million people suffering from diabetes around the world. People aged 65 years or older most affected by this disease, and it is estimated that approximately 96% of cases worldwide type 2 diabetes. with mellitus at an increased risk infections such as pneumonia, due to a series factors may contribute immune dysfunction, including hyperglycemia, inhibition neutrophil chemotaxis, impaired cytokine production, phagocytic cell altered T cell-mediated responses co-existence chronic comorbidities. Rates infection, hospitalization mortality in diabetic patients reported be higher general population. Research into infectious diseases pneumonia these very important because will help improve their management treatment.

Language: Английский

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A Review on Risk Factors, Traditional Diagnostic Techniques, and Biomarkers for Pneumonia Prognostication and Management in Diabetic Patients

Diseases, Journal Year: 2024, Volume and Issue: 12(12), P. 310 - 310

Published: Dec. 2, 2024

People of all ages can contract pneumonia, and it cause mild to severe disease even death. In addition being a major death for elderly people those with prior medical conditions such as diabetes, isthe world’s biggest infectious children. Diabetes mellitus is metabolic condition high glucose level leading lower limb amputation, heart attacks, strokes, blindness, renal failure. Hyperglycemia known impair neutrophil activity, damage antioxidant status, weaken the humoral immune system. Therefore, diabetic patients are more susceptible pneumonia than without diabetes linked fatalities. The absence quick, precise, simple, affordable ways identify etiologic agents community-acquired has made diagnostic studies’ usefulness contentious. Improvements in biological markers molecular testing techniques have significantly increased ability diagnose other related respiratory infections. Identifying risk factors developing early might lead significant decrease mortality pneumonia. this regard, various factors, traditional techniques, pathomechanisms discussed review. Further, biomarkers next-generation sequencing briefly summarized. Finding distinguish between bacterial viral could be crucial because identifying precise pathogen would stop unnecessary use antibiotics effectively save patient’s life.

Language: Английский

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Neurological Sequelae of Post-COVID-19 Fatigue: A Narrative Review of Dipeptidyl Peptidase IV-Mediated Cerebrovascular Complications

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(12), P. 13565 - 13582

Published: Nov. 28, 2024

Coronavirus disease 2019 (COVID-19) has been a global pandemic affecting millions of people’s lives, which led to ‘post-COVID-19 fatigue’. Alarmingly, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) not only infects the lungs but also influences heart and brain. Endothelial cell dysfunction hypercoagulation, we know occur with this infection, lead thrombo-inflammation that can manifest as many myriad cardio-cerebrovascular disorders, such brain fog, fatigue, cognitive dysfunction, etc. Additionally, SARS-CoV-2 associated oxidative stress, protein aggregation, cytokine storm, mitochondrial in neurodegenerative diseases. Accordingly, identification molecular targets involved these actions could provide strategies for preventing treating disease. In particular, very common enzyme dipeptidyl peptidase IV (DPPIV) recently identified candidate co-receptor entry virus its involvement infection. addition, DPPIV reported some viruses Middle East (MERS-CoV). It mediates immunologic reactions diseases type diabetes mellitus, obesity, hypertension, have considered prime risk factors stroke among other types Unlike angiotensin-converting (ACE2), implicated aggravating course infection due disruptive effect on inflammatory signaling networks neuro–glia–vascular unit. Regarding neurological, physiological, grounds governing post-COVID-19 review focuses one reasons progressively establishes cerebrovascular grievances following SARS-CoV

Language: Английский

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Clinical outcome of patients with diabetes mellitus infected by SARS-COV-2

Revista Prevenção de Infecção e Saúde, Journal Year: 2023, Volume and Issue: 8(1)

Published: July 18, 2023

Introduction: Diabetes, a chronic metabolic disease with high prevalence in Brazil, is risk factor for severe SARS COV-2 infection. The relationship between previous glycemic control and the prognosis of patients hospitalized COVID-19 not fully understood. Objective: analyze clinical outcome diabetes mellitus infected by SARS-COV-2. Outlining: A retrospective analysis medical records was carried out using Trakcare electronic system all diabetic confirmatory diagnosis pneumonia due to clinic ward HRAN, from June August 2021, who, upon admission, performed glycated hemoglobin test analyzed it SPSS software (20.0). Results: sample 52 obtained during study period. Most are female, mean age approximately 58 years. comorbidity most associated participants systemic arterial hypertension, diabetics presenting good prior control, represented HbA1c ≤ 7%. lethality found 7.7%. Implications: shows COVID 19, but no statistical significance levels increase length stay, use non-rebreathing mask, need invasive mechanical ventilation or

Language: Английский

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