Genetic diversity and seroprevalence of Toxoplasma gondii in COVID‑19 patients; a first case-control study in Iran
BMC Infectious Diseases,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 3, 2024
Abstract
Background
Toxoplasmosis
is
a
serious
or
life-threatening
disease
in
immunosuppressed
patients
and
pregnant
women.
This
study
examined
the
likely
association
between
Toxoplasma
gondii
infection
COVID-19
with
moderate
illness.
Methods
Seventy
blood
samples
were
collected
from
at
Health
Reference
Laboratory
of
Tabriz,
Northwest
Iran
April
2021
to
September
2021.
In
addition,
70
healthy
subjects
same
age
(37
±
15
years)
sex
distribution
ethnically
matched.
Sera
for
detection
anti
-Toxoplasma
antibodies
using
ELISA.
Nested-PCR
targets
amplified
based
on
B1
GRA6
genes.
amplicons
subjected
sequencing
phylogenetic
analysis.
Results
The
seroprevalence
toxoplasmosis
IgG
titer
was
35.7%
COVID‑19
27.1%
control
group,
representing
not
be
associated
seropositivity
(
P
=
0.18)
compared
subjects.
Anti-
T.
IgM
found
any
individuals.
According
PCR
amplification
genes,
frequency
14.2%
(10/70).
However,
no
detected
group.
CD4
+
T
cell
count
relatively
lower
toxoplasmosis-infected
(430–450
cells/mm3)
than
group
(500–1500
cells/mm3).
High
genetic
diversity
(Hd:
0.710)
type
I
strain
characterized
patients.
Present
results
showed
that
consumption
raw
vegetables
close
contact
stray
cats
can
increase
transmission
<
0.01).
Conclusions
current
revealed
unequivocally
circulating
among
Tabriz;
significant
observed
occurrence
severity
COVID-19.
To
make
more
accurate
health
decisions,
multicenter
investigations
larger
sample
size
different
ethnic
groups
Iranian
population
are
needed.
Language: Английский
A Review of Immunological and Neuropsychobehavioral Effects of Latent Toxoplasmosis on Humans
Parasite Immunology,
Journal Year:
2024,
Volume and Issue:
46(7)
Published: July 1, 2024
ABSTRACT
Toxoplasmosis
as
a
zoonotic
disease
has
worldwide
distribution
and
can
infect
wide
range
of
animal
hosts,
well
at
least
one
third
the
world's
human
population.
The
is
usually
mild
or
asymptomatic
in
immunocompetent
individuals,
but
dormant
tissue
cysts
survive
especially
brain
for
host
lifespan,
known
latent
toxoplasmosis
(LT).
Recent
studies
suggest
that
LT
have
certain
neurological,
immunological
psychological
behavioural
effects
on
including
schizophrenia,
bipolar
disorder,
Alzheimer's
disease,
depression,
suicide
anxiety
sleeping
disorders.
are
controversial,
their
exact
mechanisms
action
not
yet
fully
understood.
This
review
aims
to
provide
an
overview
potential
effects,
basic
alteration
neurotransmitter
levels,
immune
activation
central
nervous
system
induction
oxidative
stress.
Additionally,
beneficial
LT,
explanation
within
framework
manipulation
hypothesis,
finally,
challenges
limitations
current
research
discussed.
Language: Английский
Association between breakthrough infection with COVID-19 and Toxoplasma gondii: a cross-sectional study
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Oct. 17, 2023
Abstract
The
breakthrough
infection
following
COVID-19
vaccination
has
been
a
subject
of
concern
recently.
Evidence
suggests
that
vaccine
efficacy
diminishes
over
time
due
to
multiple
factors
related
the
host,
and
vaccine.
Coinfection
with
other
pathogens
was
claimed
earlier
as
contributing
cause
for
this
phenomenon.
Hence,
we
aimed
stratify
association
post-COVID-19
coinfection
Toxoplasma
gondii
(
T.
)
its
impact
on
disease
severity.
This
cross-sectional
study
included
330
COVID-19-vaccinated
patients
confirmed
by
RT-PCR.
They
were
also
screened
anti-
antibodies
using
ELISA.
seropositive
cases’
whole
blood
DNA
PCR
correlate
results
Out
vaccinated
infection,
34.5%
(114
patients)
showed
positivity
IgG
ELISA,
none
cases
IgM
positive.
Eleven
(9.6%)
IgG-positive
positive
PCR.
Positive
correlated
positively
titer
P
<
0.001),
Cutoff
point
191.5.
Molecular
analysis
severity
8
(72.7%),
1
(9.1%),
2
(18.2%)
had
mild,
moderate,
severe
courses
disease,
respectively,
no
significant
correlation.
Our
reported
heightened
prevalence
latent
toxoplasmosis
among
mild
infection.
Nevertheless,
discernible
correlation
between
is
lacking.
implementing
studies
larger
scale
could
provide
more
comprehensive
comprehension
association.
Language: Английский
Impact of latent toxoplasmosis on pneumonic and non-pneumonic COVID-19 patients with estimation of relevant oxidative stress biomarkers
Folia Parasitologica,
Journal Year:
2024,
Volume and Issue:
71
Published: April 4, 2024
Susceptibility
to
COVID-19,
the
most
devastating
global
pandemic,
appears
vary
widely
across
different
population
groups.
Exposure
toxoplasmosis
has
been
proposed
as
a
theory
explain
diversity
of
these
populations.
The
aim
present
study
was
investigate
possible
association
between
latent
and
COVID-19
its
probable
correlation
with
markers
oxidative
stress,
C-reactive
protein
(CRP)
ferritin.
In
case-control
study,
blood
samples
were
collected
from
91
confirmed
(48
non-pneumonic;
NP,
43
pneumonic;
P)
patients
45
healthy
controls.
All
participants
tested
for
IgG
anti-Toxoplasma
gondii
antibodies
stress
(nitric
oxide
[NO],
superoxide
dismutase
[SOD]
reduced
glutathione
[GSH]),
CRP
serum
ferritin
levels
determined.
patients,
anti-T.
found
in
54%
compared
7%
control
group,
difference
being
statistically
significant
(P
˂
0.001).
However,
no
severity
T.
infection.
Latent
had
strong
influence
on
risk
COVID-19.
NO
SOD
significantly
increased
while
GSH
decreased
them
subjects
0.001
both
values).
also
elevated
P
infected
toxoplasmosis.
This
is
first
look
at
importance
indicators
co-infection
gondii.
high
prevalence
suggests
that
infection
can
be
considered
indicator
Language: Английский
Frequency of exposure to Toxoplasma gondii in COVID-19 patients. a systematic review and meta-analysis
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 6, 2024
Abstract
Background
Toxoplasmosis
is
a
chronic
protozoan
parasitic
infection
that
affects
nearly
one-third
of
the
global
population.
During
COVID-19
pandemic,
cases
were
observed
in
patients
with
and
toxoplasmosis.
Therefore,
this
systematic
review
meta-analysis
aimed
to
determine
frequency
Toxoplasma
gondii
exposure
COVID-19.
Methods
A
literature
search
was
conducted
six
databases
(PubMed,
Scopus,
Embase,
Web
Science,
ScienceDirect,
Google
Scholar)
until
March
3,
2024.
Study
selection,
quality
assessment,
data
extraction
performed
independently
by
three
investigators.
Statistical
analysis
using
R
version
4.3,
applying
random-effects
model.
The
included
observational
studies
assessed
"JBI-MAStARI".
Results
total
5,936
retrieved,
13
which
final
meta-analysis.
sample
2,947
from
four
countries,
whom
approximately
43.26%
men
49.41%
women.
Among
patients,
1,323
showed
evidence
T.
through
IgG
detection,
while
1,302
specifically
examined
for
presence
IgM
36
positive
identified.
,
determined
COVID-19,
reached
49%
(95%
CI:
34-63%;
participants;
studies;
I
2
=
98%,
p
<
0.01).
In
addition,
evaluated
2%
0-6%;
6
94%,
Conclusion
It
shown
almost
half
had
previous
IgG,
small
percentage,
2%,
active
detection.
Language: Английский
Frequency of exposure to Toxoplasma gondii in COVID-19 patients: a systematic review and meta-analysis
BMC Public Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 19, 2024
Toxoplasmosis
is
a
chronic
protozoan
parasitic
infection
that
affects
nearly
one-third
of
the
global
population.
During
COVID-19
pandemic,
cases
were
observed
in
patients
with
and
toxoplasmosis.
Therefore,
this
systematic
review
meta-analysis
aimed
to
determine
frequency
Toxoplasma
gondii
exposure
COVID-19.
A
literature
search
was
conducted
six
databases
or
tools
(PubMed,
Scopus,
Embase,
Web
Science,
ScienceDirect,
Google
Scholar)
until
March
3,
2024.
Study
selection,
quality
assessment,
data
extraction
performed
independently
by
three
investigators.
Statistical
analysis
using
R
version
4.3,
applying
random-effects
model.
The
included
observational
studies
assessed
"JBI-MAStARI".
total
5,936
retrieved,
13
which
final
meta-analysis.
sample
2,947
from
four
countries,
whom
approximately
43.3%
men
49.4%
women.
Among
patients,
1,323
showed
evidence
T.
through
IgG
detection,
while
1,302
explicitly
examined
for
IgM
36
positive
identified.
gondii,
determined
presence
COVID-19,
reached
49%
(95%
CI:
34–63%;
participants;
studies;
I2
=
98%,
p
<
0.01).
In
addition,
evaluated
2%
0–6%;
6
94%,
It
shown
almost
half
had
previous
IgG,
small
percentage,
2%,
active
detection.
Although
results
indicate
possible
correlation
between
it
essential
note
study
based
on
research,
precludes
establishing
causal
relationship.
Consequently,
further
research
required
deepen
understanding
interaction
two
conditions.
Joanna
Briggs
Institute
Meta-Analysis
Statistics
Assessment
Review
Instrument
(JBI-MAStARI),
Prospective
International
Registry
Systematic
Reviews
(PROSPERO),
Preferred
Reporting
Items
Meta-Analyses
(PRISMA).
Language: Английский
Prevalence of Toxoplasma gondii infection in covid-19 patients: a systematic review and meta-analysis
Mahdi Fakhar,
No information about this author
Khadijeh Najafi Ghobadi,
No information about this author
Nastaran Barati
No information about this author
et al.
Microbial Pathogenesis,
Journal Year:
2024,
Volume and Issue:
197, P. 107064 - 107064
Published: Oct. 21, 2024
Language: Английский
Coinfection of Toxoplasma gondii and Other Microorganisms: A Systematic Review and Meta-Analysis
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2106 - 2106
Published: Oct. 21, 2024
Toxoplasmosis
is
a
disease
caused
by
the
intracellular
protozoan
Language: Английский