Advanced Optimization of Bioprocess Parameters for Exopolysaccharides Synthesis in Extremophiles

Processes, Journal Year: 2025, Volume and Issue: 13(3), P. 822 - 822

Published: March 11, 2025

Exopolysaccharides (EPSs) represent versatile biopolymers finding diverse applications in food, pharmaceuticals, and bioremediation industries. Extremophiles, thriving under extreme environmental conditions, have emerged as a promising source of novel EPSs with better stability bioactivity. The present work reviews the complex influence various abiotic factors bioprocess parameters such temperature, pH, carbon nitrogen sources, C/N ratios, oxygen transfer dynamics on production from extremophilic microorganisms. Results underline important role temperature for structural functional properties EPSs, synthesis cryoprotective polymers psychrophiles to thermostable thermophiles cold stress. pH has an extensive effect enzymatic activities: optimal neutral slightly acidic conditions exist most strains. Carbon sources determine not only yield but also its features, while ratios regulate balance between biomass polymer biosynthesis. Besides that, limitations—which may happen particularly viscous or saline media—are overtaken by optimized bioreactor configuration stirring strategies. These findings are highly relevant development tailored cultivation enabling maximization EPS yields adaptation comply industrial requirements. This study provides framework enhancing leveraging adaptive traits extremophiles. approach supports sustainable use biopolymers, advances fermentation processes, helps uncover underlying mechanisms involved.

Language: Английский

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Hand-to-surface bacterial transfer and healthcare-associated infections prevention: a pilot study on skin microbiome in a molecular biology laboratory

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 21, 2025

Background Healthcare-associated infections (HAIs) are a major global public health problem, contributing significantly to patient morbidity and mortality. This study analyses differences in type amounts of bacteria transferred from volunteers’ dominant palm two healthcare-relevant surfaces (glass laminate table), both before after hand washing with water antibacterial soap. The aim was understand hand-to-surface microbial contamination support the development HAI prevention strategies. Methods Microbial DNA extracted sequenced identify species. Taxonomic statistical were performed evaluate bacterial diversity abundance across experimental groups. Results results confirmed greater species richness on compared surfaces, significant reduction washing, especially glass. Taxa analysis highlighted increased persistence Gram-negative HAIs-related surface, while Gram-positive opportunistic more abundant palms glass surface. Beta composition between groups, highlighting importance bacteria-surface characteristics designing preventive measures. Conclusion Despite some limitations, our emphasizes microbiological surveillance for all pathogenic potential. These findings can contribute effective guidelines surface disinfection key elements preventing HAIs.

Language: Английский

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Probiotic Potential and Exopolysaccharide Characterization of Two Native Lactic Acid Bacteria for Functional Applications

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106600 - 106600

Published: April 1, 2025

Language: Английский

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Phenotyping the Chemical Communications of the Intestinal Microbiota and the Host: Secondary Bile Acids as Postbiotics

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 595 - 595

Published: April 15, 2025

The current definition of a postbiotic is “preparation inanimate microorganisms and/or their components that confers health benefit on the host”. Postbiotics can be mainly classified as metabolites, derived from intestinal bacterial fermentation, or structural components, intrinsic constituents microbial cell. Secondary bile acids deoxycholic acid (DCA) and lithocholic (LCA) are metabolites generated by enzymatic modifications primary enzymes. function receptor ligands modulating activity family bile-acid-regulated receptors (BARRs), including GPBAR1, Vitamin D (VDR) RORγT expressed various cell types within entire human body. integrate postbiotics, exerting potential beneficial effects given ability to regulate multiple biological processes such glucose metabolism, energy expenditure inflammation/immunity. Although there evidence might harmful intestine, most this does not account for dysbiosis. This review examines novel conceptual framework secondary postbiotics how these mediators participate in maintaining host health.

Language: Английский

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Indirect impact of quorum sensing on corrosion of graphene-coated copper via sulfate-reducing bacteria biofilm enhancement

Corrosion Science, Journal Year: 2025, Volume and Issue: unknown, P. 112988 - 112988

Published: April 1, 2025

Language: Английский

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