Anthranilic Acid: A Versatile Monomer for the Design of Functional Conducting Polymer Composites

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(6), P. 208 - 208

Published: June 3, 2024

Polyaniline has been utilized in various applications, yet its widespread adoption often impeded by challenges. Composite systems have proposed as a means of mitigating some these limitations, and anthranilic acid (2-aminobenzoic acid) emerged possible moderator for use co-polymer systems. It offers improved solubility retention electroactivity neutral alkaline media, and, significantly, it can also bestow chemical functionality through carboxylic substituent, which greatly ease post-polymer modification. The benefits using (as homopolymer or copolymer) demonstrated applications including corrosion protection, memory devices, photovoltaics, biosensors. Moreover, this polymer used versatile framework the sequestration metal ions water treatment, critically, same mechanisms serve facile route production catalytic metallic nanoparticles. However, polyanthranilic limited, aim present narrative review is to revisit early promise assess potential future within modern smart materials. A critical evaluation properties presented, versatility both monomer across spectrum highlighted.

Language: Английский

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Relationship Between Pyochelin and Pseudomonas quinolone signal in Pseudomonas aeruginosa: A Direction for Future Research

Published: July 4, 2024

Pseudomonas aeruginosa is an opportunistic pathogen that requires iron to survive in the host; however, host immune system limits availability of iron. Pyochelin (PCH) a major siderophore produced by P. during infection, which can help iron-restricted environment and cause infection. The infection activity regulated quinolone signal (PQS) quorum-sensing system. uses 2-heptyl-3-hydroxy-4-quinolone or its precursor, 2-heptyl-4-quinolone (HHQ), as molecule. PQS control specific life processes such mediating quorum sensing, cytotoxicity, acquisition. This review summarizes biosynthesis PCH PQS, shared transport regulatory relationship between PQS. correlation emphasized provide new direction for future research.

Language: Английский

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Systematic Insights into the Relationship between the Microbiota–Gut–Brain Axis and Stroke with the Focus on Tryptophan Metabolism

Metabolites, Journal Year: 2024, Volume and Issue: 14(8), P. 399 - 399

Published: July 24, 2024

Stroke, as a serious cerebral vascular disease with high incidence and rates of disability mortality, has limited therapeutic options due to the narrow time window. Compelling evidence highlighted significance gut microbiota gut-brain axis critical regulatory factors affecting stroke. Along microbiota-gut-brain axis, tryptophan metabolism further acquires increasing attention for its intimate association central nervous system diseases. For purpose exploring potential role in stroke providing systematic insights into intricate connection pathological procedure stroke, this review first summarized practical relationship between by compiling latest case-control research. Then, well interaction were comprehensively elucidated on basis basic anatomical structure physiological function. Based crosstalk microbiota-gut-brain, we focused from three major metabolic pathways, namely, kynurenine pathway, serotonin microbial within axis. Moreover, effects appreciated elaborated here, which is scarcely found other reviews. Hopefully, illustration mechanisms pathways along will inspire more translational research perspectives, paid promising pharmaceutical target order reduce risk mitigate progression, ameliorate prognosis.

Language: Английский

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Characterization of anthranilic acid produced by Virgibacillus salarius MML1918 and its bio-imaging application

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(6)

Published: April 17, 2024

Language: Английский

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Anthranilic Acid–G-Protein Coupled Receptor109A–Cytosolic Phospholipase A2–Myelin–Cognition Cascade: A New Target for the Treatment/Prevention of Cognitive Impairment in Schizophrenia, Dementia, and Aging

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13269 - 13269

Published: Dec. 10, 2024

Cognitive impairment is a core feature of neurodevelopmental (schizophrenia) and aging-associated (mild cognitive Alzheimer’s dementia) neurodegenerative diseases. Limited efficacy current pharmacological treatments warrants further search for new targets nootropic interventions. The breakdown myelin, phospholipids axonal sheath that protects the conduction nerve impulse between neurons, was proposed as neuropathological abnormality precedes promotes deposition amyloid-β in neuritic plaques. present review recent literature our own pre- clinical data suggest (for first time) anthranilic acid (AA)-induced activation microglial-expressed G-protein coupled receptor (GPR109A) inhibits cytosolic phospholipase A2 (cPLA2), an enzyme triggers degradation myelin consequently attenuates impairment. suggests up-regulation AA formation sex-specific compensatory (adaptive) reaction aimed to prevent/treat AA–GPR109A–cPLA2–myelin–cognition cascade interventions, e.g., administration pegylated kynureninase, catalyzes from Kynurenine (Kyn), tryptophane catabolite; interferon-alpha; central peripheral Kyn aminotransferase inhibitors increase availability substrate formation; vagus stimulation. predicts activity exogenous GPR109A agonists were designed underwent trials (unsuccessful) anti-dyslipidemia agents. might contribute pathogenesis Data on disorders are scarce, needs exploration studies

Language: Английский

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