Tracheal tube infections in critical care: A narrative review of influencing factors, microbial agents, and mitigation strategies in intensive care unit settings DOI Creative Commons
Tahereh Motallebirad, Mohammad Reza Mohammadi, Ali Jadidi

et al.

SAGE Open Medicine, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 1, 2024

Tracheal tube infections pose significant challenges in the management of mechanically ventilated patients intensive care units. These contribute to prolonged unit stays, increased healthcare costs, spread antibiotic resistance, and poor patient outcomes. This study aims elucidate complex relationship between environmental factors, hospital practices, incidence tracheal infections. Our comprehensive review explores impact factors such as air quality, water sources, equipment contamination, ventilation strategies, infection control protocols, microbial reservoirs within settings on rates. Additionally, it investigates global variations prevalence, which are influenced by differences infrastructure, adherence, resistance profiles, demographics. findings highlight importance targeted interventions collaborative approaches reduce burden improve By fully understanding interplay conditions effective prevention strategies can be developed outcomes resources, ultimately enhancing quality critical settings.

Language: Английский

Mechanical Ventilator-Associated Pneumonia in the COVID-19 Pandemic Era: A Critical Challenge in the Intensive Care Units DOI Creative Commons
M Stoian, Adina Andone,

Sergiu Rareș Bândilă

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 28 - 28

Published: Jan. 3, 2025

Background/Objectives: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection encountered in intensive care unit (ICU) and associated with prolonged hospitalization increased mortality. We evaluated causative pathogens involved their resistance to major classes of antibiotics patients VAP assessed differences between without coronavirus disease 2019 (COVID-19). Materials Methods: This study was a single-center, cross-sectional, retrospective analysis involving 122 who were hospitalized ICU Târgu Mureș County Clinical Hospital from 1 April 2021, 2023. compares COVID-19 non-COVID-19 groups, examining clinical progression, duration ventilation hospitalization, mortality, pathogen distribution, emergence multidrug-resistant strains. Results: A length stay exceeding 11.5 days development (MDR) infections (AUC: 0.708, p < 0.001). Similarly, MV 196 h MDR acquisition 0.695, = 0.002). Additionally, Pulmonary Infection Score (CPIS) greater than 5 0.854, 0.001) whole group patients. The commonly isolated strains Acinetobacter spp., Pseudomonas Klebsiella Staphylococcus aureus. Among patients, there notably higher frequency baumannii. bacterial carbapenems found spp. (51.6%), (22.6%), (25.8%). Conclusions: experienced longer ventilation, an risk developing MDR. Carbapenem universal pneumoniae, whereas aeruginosa more prevalent among strongly correlates both patient groups.

Language: Английский

Citations

3
The association between neonatal mortality and ventilator association pneumonia DOI Creative Commons
Mai El-Sayad Abd El-Hamid,

Marwa Fekry Hassan,

Mohamed A. Hafez

et al.

Alexandria Journal of Medicine, Journal Year: 2025, Volume and Issue: 61(1), P. 154 - 163

Published: Jan. 16, 2025

Background Ventilator association pneumonia (VAP) is a common healthcare-associated disease that primarily challenges ventilated neonates in neonatal intensive care units (NICU). This study aims to evaluate the between mortality and ventilator-associated pneumonia.

Language: Английский

Citations

0
Ventilator-Associated Pneumonia in Intensive Care Units: A Comparison of Pre-Pandemic and COVID-19 Periods DOI Open Access
Soňa Hlinková, Eva Moraučíková, Agnieszka Strzelecka

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 1000 - 1000

Published: Feb. 4, 2025

Background/Objectives: The COVID-19 pandemic has significantly increased the burden of ventilator-associated pneumonia (VAP) in intensive care units (ICUs) globally. However, epidemiological data on VAP Slovak ICUs, particularly context pandemic, remain limited. This study aimed to evaluate incidence, microbial profiles, and risk factors ICU settings, during pandemic. Methods: A retrospective analysis was conducted for respiratory unit (ICU) patients a university hospital, comparing from pre-pandemic periods. CDC/NHSN definitions were applied, statistical analyses performed using STATISTICA 13.1. Results: total 803 analyzed, representing 8385 bed days 5836 mechanical ventilator days. rates by 111%, 8.46 17.86 events per 1000 MV (p < 0.001). non-COVID-19 86% compared levels. Pandemic conditions also mortality 25.66% 40.52% identified as critical determinant mortality, contributing 21.62% higher rate among Younger age, prolonged ventilation, medical (vs. surgical) hospitalizations associated with incidence. Gram-negative bacteria dominated pathogen significant increases observed Pseudomonas aeruginosa (183%), Klebsiella pneumoniae (150%), Acinetobacter spp. (100%). Conclusions: affected incidence epidemiology highlighting systemic vulnerabilities HAI surveillance IPC practices.

Language: Английский

Citations

0
The Interactive Dynamics of Pseudomonas aeruginosa in Global Ecology DOI Open Access
Telma de Sousa, Catarina Silva, Gilberto Igrejas

et al.

Journal of Basic Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

ABSTRACT Pseudomonas aeruginosa is an opportunistic bacterium widely distributed in both natural and urban environments, playing a crucial role global microbial ecology. This article reviews the interactive dynamics of P. across different ecosystems, highlighting its capacity for adaptation resistance response to environmental therapeutic pressures. We analyze mechanisms antibiotic resistance, including presence genes efflux systems, which contribute persistence clinical nonclinical settings. The interconnection between human, animal, health, within context One Health concept, discussed, emphasizing importance monitoring sustainable management practices mitigate spread resistance. Through holistic approach, this work offers insights into influence on public health biodiversity.

Language: Английский

Citations

0
Procalcitonin as a biomarker for postoperative pneumonia: a study on dynamics following cardiopulmonary bypass in adults DOI Creative Commons

G. Le Mao,

Liyun Wang, Wensen Chen

et al.

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 30, 2025

Language: Английский

Citations

0
Impact of prolonged versus intermittent infusion of meropenem on mortality and clinical outcomes in patients with severe infection: A systematic review and meta-analysis DOI
昭 高木, Jinli Wang,

En Mu

et al.

Journal of Infection and Chemotherapy, Journal Year: 2025, Volume and Issue: unknown, P. 102634 - 102634

Published: Jan. 1, 2025

Language: Английский

Citations

0
Inhaled Alone versus Inhaled Plus Intravenous Polymyxin B for the Treatment of Pneumonia Due to Carbapenem-Resistant Gram-Negative Bacteria: A Prospective Randomized Controlled Trial DOI
Yu Cheng, Lili Zhou,

Danjie Wang

et al.

International Journal of Antimicrobial Agents, Journal Year: 2025, Volume and Issue: unknown, P. 107483 - 107483

Published: Feb. 1, 2025

Language: Английский

Citations

0
Impact of sedation levels on outcomes in neurocritical care patients with intracranial hemorrhage: a retrospective cohort study DOI
Hyo Jeong Kim,

Yoohyun Kwon,

Jae Yeon Seok

et al.

Neurosurgical Review, Journal Year: 2025, Volume and Issue: 48(1)

Published: April 3, 2025

Language: Английский

Citations

0
Model-based translation of the PKPD-relationship for linezolid and vancomycin on methicillin-resistant Staphylococcus aureus: from in vitro time–kill experiments to a mouse pneumonia model DOI Creative Commons
Diego Vera‐Yunca,

Carina Matias,

Carina Vingsbo Lundberg

et al.

Journal of Antimicrobial Chemotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Objectives MRSA is one of the main pathogens that cause nosocomial pneumonia. Based on longitudinal in vitro and vivo data, a pharmacokinetic–pharmacodynamic (PKPD) model was built to quantify effect two control antibiotics (LZD VAN) for Gram-positive bacteria standardized mouse pneumonia Methods The PKPD developed data generated strain 160 079 static time–kill experiments thereafter adjusted fit from lungs neutropenic mice administered with single or multiple doses LZD (0.5–40 mg/kg) VAN (1–40 mg/kg). Simulations human PK were run predict antibacterial response patients. Results Bacterial regrowth observed when exposed concentrations described by an adaptive resistance model. selected isolate showed good virulence load decreased up 2-log respect after treatment. A 70%–75% lower killing rate estimated compared vitro. displayed bacterial stasis at 24 h patients infected MICs below clinical breakpoint both drugs administering standard-of-care dosing regimens. Conclusions translational workflow allowed us build characterized dynamics following exposure, showing this approach can inform development antibiotics. We also showcased first successful use bacteria.

Language: Английский

Citations

0
Investigating the Effectiveness of Ceragenins against Acinetobacter baumannii to Develop New Antimicrobial and Anti-Adhesive Strategies DOI Open Access
Maciej Karasiński, Urszula Wnorowska, Tamara Daniluk

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7036 - 7036

Published: June 27, 2024

A growing body of experimental data indicates that ceragenins (CSAs), which mimic the physicochemical properties host's cationic antimicrobial peptide, hold promise for development a new group broad-spectrum antimicrobials. Here, using set in vivo experiments, we assessed potential eradication an important etiological agent nosocomial infections, Acinetobacter baumannii. Assessment bactericidal effect CSA-13, CSA-44, and CSA-131 on clinical isolates A. baumannii (n = 65) their effectiveness against bacterial cells embedded biofilm matrix after growth abiotic surfaces showed strong tested molecules regardless pattern. AFM assessment cell topography, stiffness, adhesion significant membrane breakdown rheological changes, indicating ability to target surface structures cells. In culture A549 lung epithelial cells, ceragenin CSA-13 had inhibit host suggesting it interferes with mechanism invasion. These findings highlight as therapeutic agents strategies infections caused by

Language: Английский

Citations

1