Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

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Gut Microbiota Disruption in Hematologic Cancer Therapy: Molecular Insights and Implications for Treatment Efficacy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10255 - 10255

Published: Sept. 24, 2024

Hematologic malignancies (HMs), including leukemia, lymphoma, and multiple myeloma, involve the uncontrolled proliferation of abnormal blood cells, posing significant clinical challenges due to their heterogeneity varied treatment responses. Despite recent advancements in therapies that have improved survival rates, particularly chronic lymphocytic leukemia acute lymphoblastic treatments like chemotherapy stem cell transplantation often disrupt gut microbiota, which can negatively impact outcomes increase infection risks. This review explores complex, bidirectional interactions between microbiota cancer patients with HMs. Gut influence drug metabolism through mechanisms such as production enzymes bacterial β-glucuronidases, alter efficacy toxicity. Moreover, microbial metabolites short-chain fatty acids modulate host immune response, enhancing effectiveness. However, therapy reduces diversity beneficial bacteria, Bifidobacterium Faecalibacterium, while increasing pathogenic bacteria Enterococcus Escherichia coli. These findings highlight critical need preserve during treatment. Future research should focus on personalized microbiome-based therapies, probiotics, prebiotics, fecal transplantation, improve quality life for hematologic malignancies.

Language: Английский

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Evaluation of Drug Permeation Enhancement by Using In Vitro and Ex Vivo Models

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 195 - 195

Published: Jan. 31, 2025

Drugs administered by means of extravascular routes drug administration must be absorbed into the systemic circulation, which involves movement molecules across biological barriers such as epithelial cells that cover mucosal surfaces or stratum corneum covers skin. Some drugs exhibit poor permeation membranes may experience excessive degradation during first-pass metabolism, tends to limit their bioavailability. Various strategies have been used improve Absorption enhancement include co-administration chemical enhancers, enzymes, and/or efflux transporter inhibitors, changes, and specialized dosage form designs. Models with physiological relevance are needed evaluate efficacy absorption techniques. in vitro cell culture models ex vivo tissue explored quantify effectiveness strategies. This review deliberates on use for evaluation selected including nasal, oromucosal, pulmonary, oral, rectal, transdermal administration.

Language: Английский

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A Mini-Review on Enhancing Solubility in Topical Hydrogel Formulations Using Solid Dispersion Technology for Poorly Water-Soluble Drugs

Colloids and Interfaces, Journal Year: 2025, Volume and Issue: 9(2), P. 17 - 17

Published: March 21, 2025

The solubility behavior of drugs is a critical factor in formulation development. Approximately 40–45% new face market entry challenges due to low water solubility. Enhancing drug bioavailability thus essential developing pharmaceutical dosage forms. Many biopharmaceutical class II and IV are commonly prescribed treat inflammations, infections, pain from various pathologies. Their oral administration has several drawbacks, including significant first-pass liver effects, bioavailability, adverse gastrointestinal effects. Topical application gained relevance its advantages delivering directly the target site, avoiding irritation, increasing their effectiveness. However, topical hydrogel formulations with poorly water-soluble related skin’s permeability. Therefore, preparing hydrogels using solid dispersions (SDs) an effective strategy enhance dissolution rate soluble drugs, thereby improving bioavailability. In this review, concepts SDs, delivery systems, incorporating as well preparation methods, characterization, applications, will be discussed.

Language: Английский

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Targeted and intelligent nano-drug delivery systems for colorectal cancer treatment

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 25, 2025

Colorectal cancer (CRC) remains a highly heterogeneous malignancy with significant morbidity and mortality worldwide. Despite advancements in surgery, chemotherapy, immunotherapy, targeted therapy, treatment efficacy is often hampered by drug resistance systemic toxicity. In recent years, nano-drug delivery systems (NDDS) have emerged as promising strategy to enhance therapeutic precision, reduce adverse effects, overcome CRC treatment. This review discusses the NDDS for treatment, focusing on optimization of oral systems, development tumor-specific targeting strategies, design intelligent responsive tumor microenvironment (TME). Furthermore, we summarize current challenges translation explore future research directions enhancing their clinical feasibility impact.

Language: Английский

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“Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems”

Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 16, 2024

Polymers have become a versatile tool in pharmaceutical chemistry through techniques and new formulation. This review presents an overview of the general topic drug delivery polymers, places particular focus on their specific contributions, discusses significant issues like biocompatibility, controlled release targeted delivery. Unlike previous reviews, it captures recent development biodegradable, smart stimuli-responsive abilities to improve therapy outcomes patient adherence treatments. Furthermore, this work also has enhanced understanding advanced polymer-based systems such as polymeric nanoparticles, bioconjugation strategies natural with examples various therapeutic areas. The stands for itself by expanding discussion regulatory clinical realism difficulties well safety, efficacy, acceptance considerations. In addition, emphasizes role interdisciplinary intersectoral cooperation cross-country collaborations developing polymers-based applications precision medicine. way, provides fresh view both present advancements future possibilities technologies dedicated achievements globally inspire researchers practitioners.

Language: Английский

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