Cross-trait multivariate GWAS confirms health implications of pubertal timing

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 18, 2025

Pubertal timing is highly variable and associated with long-term health outcomes. Phenotypes pubertal include age at menarche, voice break, first facial hair growth spurt, seems to have a shared genetic architecture between the sexes. However, puberty phenotypes primarily been assessed separately, failing account for genetics, which limits reliability of purported implications. Here, we model common using multivariate GWAS, an effective population 514,750 European participants. We find 266 independent variants in 197 loci, including 18 novel variants. Transcriptomic, proteome imputation fine-mapping analyses reveal genes causal timing, KDM4C, LEPR, CCNC, ACP1, PCSK1. Linkage disequilibrium score regression Mendelian randomisation analysis establish associations earlier both accelerated ageing risk developing cardiovascular disease osteoporosis. that alanine aminotransferase, glycated haemoglobin, high-density lipoprotein cholesterol Parabacteroides levels are mediators these relationships, controlling oily fish retinol intake may be beneficial promoting healthy development.

Language: Английский

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Alterations in the gut microbiota community are associated with childhood obesity and precocious puberty

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 24, 2024

To explore the distribution and differences in intestinal microbiota girls with obesity-related precocious puberty relationship between puberty. 16 S rRNA gene amplicons from fecal samples obesity-complicated healthy children were sequenced to define microbial taxa. The α- β-diversity indices of microbiome significantly differed among three groups. At phylum level, proportions Firmicutes, Actinobacteriota, Bacteroidota, Bacteria, Campylobacterota, Acidobacteriota different. genus there Bifidobacterium, Bacteroides, Anaerostipes, Fusicatenibacter, Klebsiella, Lachnospiraceae, ErysipelotrichaceaeUCG-003, Prevotella9, Ruminococcus gnavus group, Lachnoclostridium. Additionally, Candidatus Microthrix, Eubacterium hallii Erysipelotrichaceae UCG-003 identified as bacterial biomarkers by LEfSe. Furthermore, Sellimonas, Intestinibacter, Oscillibacter differential random forest. A receiver operating characteristic (ROC) curve was used evaluate high predictive value for Spearman correlation analysis confirmed that Anaerostipes levels negatively correlated body weight, mass index (BMI), bone age, luteinizing hormone, follicle-stimulating estradiol. There a significant obesity-associated gut microbiota, especially functional characteristics its interactions, which can provide theoretical basis clinical intervention obesity through microbiome.

Language: Английский

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Influence of gut microbiota on the pediatric endocrine system and associated disorders

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(4), P. 2149 - 2162

Published: March 27, 2025

Language: Английский

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Small Intestinal Bacterial Overgrowth and Pediatric Obesity—A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1499 - 1499

Published: April 29, 2025

Background/Objectives: Childhood obesity is a growing global concern linked to metabolic disorders such as nonalcoholic fatty liver disease (NAFLD). Small intestinal bacterial overgrowth (SIBO) may exacerbate these conditions by promoting systemic inflammation and dysfunction. This review evaluates the prevalence of SIBO in obese children, its association with inflammatory markers, efficacy diagnostic therapeutic strategies. Methods: A systematic search PubMed, Scopus, Web Science (2010-present) was conducted using Boolean operators: ('small overgrowth' OR 'SIBO') AND 'prevalence' ('low-grade markers' 'metabolic status') 'gut microbiome' 'dysbiosis' 'obese children'. Results: The data show that frequently observed pediatric populations associated gut dysbiosis, impaired nutrient absorption, reduced production short-chain acids. These changes contribute increased permeability, endotoxemia, chronic low-grade inflammation. Several microbial taxa have been proposed biomarkers targets. Diagnostic inconsistencies persist, but treatments probiotics, prebiotics, dietary interventions, selective antibiotics potential, pending further validation. Conclusions: Early identification treatment tailored strategies help reduce complications improve outcomes children obesity.

Language: Английский

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Causal relationship between the composition of the Gut Microbiota and central precocious puberty: a two-sample Mendelian randomization study

Frontiers in Pediatrics, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 14, 2024

Background Previous observational research has demonstrated a possible association between the gut microbiota (GM) and central precocious puberty (CPP). Nevertheless, whether there is causal relationship GM CPP uncertain due to possibility of confounding factors influencing result. Methods We collected summary data from genome-wide studies (MiBioGen, n = 18,340) (FinnGen Consortium, 185 case groups 395,289 controls). Most participants were European origin. Mendelian randomization analysis was utilized investigate using inverse-variance weighted average technique, median, Egger. The reliability results evaluated leave-one-out test sensitivity analyses, including heterogeneity horizontal pleiotropy testing . Results According substantial correlation composition GM. Specifically, relative abundance genus Bacteroides (OR 0.222, 95% CI 0.06–0.822, P 0.024) Alistipes 0.197, 0.056–0.697, 0.012), others, showed significant associations. Furthermore, associations with phylum Euryarchaeota , orders Gastranaerophilales Rhodospirillales families Bacteroidaceae Desulfovibrionaceae also observed. Sensitivity analyses generated positive for implying that this reliable reduces risk CPP. Conclusions may have effect on present finding be protective against expected offer novel insights into management

Language: Английский

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Methylome analysis in girls with idiopathic central precocious puberty

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 22, 2024

Abstract Background Genetic and environmental factors are implicated in many developmental processes. Recent evidence, however, has suggested that epigenetic changes may also influence the onset of puberty or susceptibility to a wide range diseases later life. The present study aims investigate genomic DNA methylation profiles associated with pubertal analyzing human peripheral blood leukocytes from three different groups subjects: 19 girls central precocious (CPP), 14 healthy prepubertal matched by age 13 stage. For this purpose, comparisons were performed between pre- controls identify normal transition CPP versus controls. Results Analysis identified 1006 differentially methylated CpG sites, 86% them found be hypermethylated Some these sites reside genes menarche transcription involved process development. methylome patients showed 65% 55% hypomethylated compared controls, respectively. In addition, interestingly, our results revealed presence 43 coding for zinc finger (ZNF) proteins. Gene ontology IPA analysis studied significant enrichment some pathways related neuronal communication (semaphorin gustation pathways), estrogens action, cancers (particularly breast ovarian) metabolism sirtuin). Conclusions indicate regulation humans is specific changes. Differentially include ZNF play role control. data highlight status signaling determine migration function GnRH neurons metabolic neoplastic

Language: Английский

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Metabolomic disorders caused by an imbalance in the gut microbiota are associated with central precocious puberty

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Central precocious puberty (CPP) is characterized by the premature activation of hypothalamic-pituitary-gonadal axis, resulting in early onset sexual development. The incidence CPP has been rising recent years, with approximately 90% cases lacking a clearly identifiable etiology. While an association between and gut microbiota observed, precise causal pathways underlying mechanisms remain poorly understood. study aims to investigate potential through which imbalances may contribute CPP.

Language: Английский

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Microbiome in Teenagers – Acquisition and Development

BENTHAM SCIENCE PUBLISHERS eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: July 22, 2024

Adolescence is the stage of life between childhood and adulthood, ranging from 10 to 19 years. It a distinct period in human development crucial for setting groundwork long-term health. Teenagers grow quickly terms their physical, cognitive, emotional development.In body teenagers, major changes microorganisms take place. With these microbiome diseases are also developed. future world. Microbiota have an impact on emotions, thoughts, decisions, interactions with others environment. This chapter written acknowledge readers about resident during adolescence many kinds that occur due lifestyle changes.

Language: Английский

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