Inorganics,
Journal Year:
2024,
Volume and Issue:
12(12), P. 308 - 308
Published: Nov. 26, 2024
Recently,
we
discovered
and
proved
the
essentiality
of
organic
boron
species
(OBS),
such
as
borate–pectic
polysaccharides
borate–phenolic
esters,
for
healthy
symbiosis
(HS)
between
microbiota
human/animal
(H/A)
host.
The
OBS
will
provide
new
options
B
supplementation
in
H/A
nutrition
a
long
life.
New
knowledge
on
naturally
occurring
microbiota-accessible
borate
HS
host
allow
use
natural
B-based
dietary
supplements
to
target
microbiome
(the
gut,
skin,
oral,
scalp,
vaginal
microbiome).
In
literature,
there
is
evidence
that
certain
bacteria
need
(autoinducer-2
borate)
communication
our
preliminary
data
show
takes
place
when
colonic
mucus
gel
layer
contains
B.
Subsequently,
become
novel
prebiotic
candidates
colon
foods.
BMC Gastroenterology,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Aug. 19, 2024
Constipation
is
one
of
the
most
common
gastrointestinal
disorders
afflicting
population,
with
recent
observational
studies
implicating
dysfunction
gut
microbiota
in
constipation.
Despite
indicating
a
relationship,
clear
causality
remains
unclear.
This
study
aims
to
use
two-sample
Mendelian
randomization
(MR)
establish
clearer
causal
relationship
between
two.
The Journal of Infectious Diseases,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Abstract
Background
Aging-related
comorbidities
are
more
common
in
people
with
human
immunodeficiency
virus
(HIV)
compared
to
without
HIV.
The
gut
microbiome
may
play
a
role
healthy
aging;
however,
this
relationship
remains
unexplored
the
context
of
Methods
16S
rRNA
gene
sequencing
was
conducted
on
stool
from
1409
women
(69%
HIV;
2304
samples)
and
990
men
(54%
1008
MACS/WIHS
Combined
Cohort
Study.
Associations
age
diversity,
uniqueness,
genus-level
abundance
were
examined
separately,
followed
by
examining
relationships
aging-related
genera
frailty
(Fried
phenotype)
mortality
risk
(Veterans
Aging
Study
[VACS]
index).
Results
Older
associated
greater
diversity
Akkermansia
Streptococcus,
lower
Prevotella
Faecalibacterium,
among
others;
findings
generally
consistent
sex
HIV
status.
An
score,
generated
via
combination
18
age-related
genera,
significantly
increased
both
independently
demographic,
behavioral,
cardiometabolic
factors.
In
general,
strongly
related
features
(eg,
score)
HIV,
but
age-microbiome
associations
similar
Some
healthy/unhealthy
aging,
such
as
Faecalibacterium
(related
reduced
frailty)
Streptococcus
higher
VACS
Conclusions
Age
is
changes
or
microbiota
declines
health.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(4), P. 725 - 725
Published: March 24, 2025
Bibliometric
analyses
are
increasingly
used
to
evaluate
scientific
domains,
revealing
research
trends,
productivity,
and
impact.
This
study
provides
a
bibliometric
analysis
of
microbiome-related
conducted
by
Greek
scientists.
Data
were
retrieved
from
the
Scopus
database,
using
keyword
“microbiome”
(English)
for
publications
until
December
2024.
was
performed
VOSviewer
bibliometrix
package
in
R.
Our
findings
indicate
that
output
has
increased
exponentially
since
2018,
with
National
Kapodistrian
University
Athens
Aristotle
Thessaloniki
leading
microbiome
Greece.
Medicine,
biochemistry,
genetics,
molecular
biology,
immunology,
microbiology
predominant
fields.
The
highlights
“microbiome”,
“microbiota”,
“probiotics”,
“prebiotics”,
“intestinal
flora”,
“16S
rRNA”
as
central
topics.
Additionally,
we
acknowledge
role
played
alternative
microbial
markers,
including
18S
rRNA/ITS
sequencing,
fungal
diversity
studies.
demonstrates
dynamic
evolving
landscape
Greece
international
relevance
contributions
science.
Aging Cell,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
ABSTRACT
The
influence
of
gut
microbes
on
aging
has
been
reported
in
several
studies,
but
the
mediating
pathways
microbiota,
whether
there
is
a
causal
relationship
between
two,
and
biomarker
screening
validation
have
not
fully
discussed.
In
this
study,
Mendelian
Randomization
(MR)
Linkage
Disequilibrium
Score
Regression
(LDSC)
are
used
to
systematically
investigate
associations
three
indicators,
14
age‐related
diseases.
Additionally,
study
integrates
machine
learning
algorithms
explore
potential
MR
LDSC
methods
for
screening.
Gut
microbiota
found
be
risk
factor
effects
chronic
kidney
disease,
cirrhosis,
heart
failure
partially
mediated
by
indicators.
identified
through
exhibit
properties
disease
prediction
(average
AUC
=
0.731).
These
can
serve
as
auxiliary
tools
conventional
screening,
effectively
enhancing
performance
models
increased
from
0.808
0.832).
This
provides
evidence
that
supports
association
highlights
genetic
correlation
analysis
discovery.
findings
may
help
develop
new
approaches
healthy
detection
intervention.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(12), P. 6335 - 6346
Published: Jan. 1, 2024
Currently,
sleep
disorders
(SD)
in
the
elderly
are
gaining
prominence
globally
and
becoming
a
significant
public
health
concern.
Methyl
donor
nutrients
(MDNs),
such
as
vitamin
B6,
B12,
folate,
choline,
have
been
reported
to
potential
improve
disorders.
Moreover,
MDNs
help
maintain
gut
flora
homeostasis,
closely
associated
with
development
of
SD.
Nevertheless,
there
has
lack
comprehensive
human
studies
examining
association
between
intake
In
our
study,
we
comprehensively
evaluated
SD
used
16S
rRNA
gene
sequencing
explore
underlying
mechanism.
We
found
that
group
(n
=
91)
had
lower
methyl-donor
nutritional
quality
index
(MNQI)
trend
toward
compared
control
147).
Based
on
intestinal
microbiome,
beta
diversity
was
higher
high
(HQ)
low
(LQ)
group,
it
group.
This
suggests
may
regulate
by
modulating
abundance
distribution
microbiota.
Subsequently,
performed
correlation
analyses
relative
microbiota,
intake,
Pittsburgh
Sleep
Quality
Index
(PSQI),
identifying
five
genera
regulatory
roles.
The
KEGG
pathway
analysis
indicated
energy
metabolism
one-carbon
might
be
pathways
through
which
modulate
sleep.
study
offers
dietary
guidance
strategies
for
managing
provides
insights
targeted
microbiota
intervention.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1716 - 1716
Published: Aug. 1, 2024
The
term
'inflammaging'
has
been
coined
to
describe
the
chronic
state
of
inflammation
derived
from
ongoing
cycles
tissue
damage
and
subsequent
immune
responses.
This
inflammatory
status
contributes
decline
organs
physiological
functions,
accelerates
aging
process,
increases
risk
age-related
illnesses
death.
During
aging,
gut
microbiota
(GM)
undergoes
significant
changes,
including
a
decreased
diversity
species,
in
beneficial
bacteria,
rise
proinflammatory
ones,
resulting
persistent
low-grade
inflammation.
Moreover,
environmental
factors,
such
as
diet
medications,
contribute
changes
GM
function,
preventing
or
promoting
inflammaging.
narrative
review
aims
clarify
underlying
mechanisms
inflammaging
specifically
investigate
influence
several
factors
on
these
mechanisms,
while
also
exploring
potential
differences
related
sex.
lifestyle
pharmacological
interventions
will
be
suggested
promote
healthy
aging.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1719 - 1719
Published: Aug. 20, 2024
Factors
driving
accelerated
biological
age
(BA),
an
important
predictor
of
chronic
diseases,
remain
poorly
understood.
This
study
focuses
on
the
impact
diet
and
gut
microbiome
BA.
Accelerated
Klemera-Doubal
(KDM-BA)
was
estimated
as
difference
between
KDM-BA
chronological
age.
We
assessed
cross-sectional
association
diet/gut
in
117
adult
participants
from
10,000
Families
Study.
16S
rRNA
sequencing
used
to
estimate
abundances
bacterial
genera.
Multivariable
linear
mixed
models
evaluated
associations
after
adjusting
for
family
relatedness,
diet,
age,
sex,
smoking
status,
alcohol
intake,
BMI.
One
standard
deviation
(SD)
increase
processed
meat
associated
with
a
1.91-year
(
