Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 12, 2025
Background
Mild
intestinal
dysfunction,
linked
to
subtle
yet
significant
health
issues,
can
be
induced
by
lipopolysaccharide
(LPS),
a
Gram-negative
bacterial
component
that
disrupts
gut
function
and
triggers
inflammation.
Akkermansia
muciniphila
has
shown
promise
as
probiotic
for
due
its
roles
in
mucin
degradation
short-chain
fatty
acid
production.
This
study
explores
the
therapeutic
effects
of
on
LPS-induced
mild
dysfunction
mice.
Methods
Thirty-eight
6-week-old
C57BL/6
mice
were
split
into
control
(
n
=
19)
LPS-treated
groups.
received
300
μg/kg/day
LPS
4
weeks,
followed
supplementation
at
41
mg/kg/day
(Akk1)
or
82
(Akk2)
another
weeks.
Gut
microbiota
was
analyzed
via
metagenomic
sequencing,
gene
expression
evaluated
through
transcriptomics.
Results
significantly
altered
microbiota,
reducing
diversity
increasing
pathogenic
genera
like
Lachnoclostridium.
supplementation,
particularly
higher
doses,
partially
restored
beneficial
such
Muribaculum.
Transcriptomics
showed
immune
inflammatory
responses,
while
reduced
these
modulating
pathways
TNF
NF-kappa
B
signaling.
Conclusion
mitigates
restoring
balance
highlighting
potential
agent
health.
Neurobiology of Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106836 - 106836
Published: Feb. 1, 2025
Ischemic
stroke
(IS)
is
a
cerebrovascular
disease
that
predominantly
affects
middle-aged
and
elderly
populations,
exhibiting
high
mortality
disability
rates.
At
present,
the
incidence
of
IS
increasing
annually,
with
notable
trend
towards
younger
affected
individuals.
Recent
discoveries
concerning
"gut-brain
axis"
have
established
connection
between
gut
brain.
Numerous
studies
revealed
intestinal
microbes
play
crucial
role
in
onset,
progression,
outcomes
IS.
They
are
involved
entire
pathophysiological
process
through
mechanisms
such
as
chronic
inflammation,
neural
regulation,
metabolic
processes.
Although
numerous
explored
relationship
microbiota,
comprehensive
analyses
specific
microbiota
relatively
scarce.
Therefore,
this
paper
provides
an
overview
typical
changes
following
investigates
microorganisms
context.
Additionally,
it
presents
analysis
post-stroke
microbiological
therapy
diet.
The
aim
to
identify
potential
microbial
targets
for
therapeutic
intervention,
well
highlight
benefits
therapies
significance
dietary
management.
Overall,
seeks
provide
key
strategies
treatment
management
IS,
advocating
healthy
diets
health
programs
Meanwhile,
may
offer
new
perspective
on
future
interdisciplinary
development
neurology,
microbiology
nutrition.
Foods,
Journal Year:
2025,
Volume and Issue:
14(5), P. 821 - 821
Published: Feb. 27, 2025
Chronic
diseases
are
major
contributors
to
global
morbidity
and
mortality.
More
than
70%
of
deaths
worldwide
caused
by
chronic
diseases,
including
cardiovascular
(CVDs),
obesity,
type
2
diabetes,
cancer.
These
characterised
low-grade
inflammation
metabolic
dysregulation.
Incorporating
functional
foods
into
daily
diet
has
been
suggested
as
a
complementary
strategy
promote
health
lower
the
risk
non-communicable
diseases.
Functional
foods,
known
that
confer
benefits
beyond
basic
nutrition,
have
reported
exhibit
preventive
therapeutic
such
anti-inflammatory
properties
for
human
health.
Therefore,
aim
this
state-of-the-art
review
will
synthesise
findings
from
recent
high-quality
studies
investigated
modulatory
role
some
commonly
bioactive
active
compounds,
polyphenols,
omega-3
fatty
acids,
probiotics,
prebiotics,
in
pathways.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(3), P. 665 - 665
Published: March 8, 2025
Despite
the
progress
made
in
oncological
theranostics,
cancer
remains
a
global
health
problem
and
leading
cause
of
death
worldwide.
Multidrug
radiation
therapy
resistance
is
an
important
challenge
treatment.
To
overcome
this
great
concern
clinical
practice,
conventional
therapies
are
more
used
combination
with
modern
approaches
to
improve
quality
patients’
lives.
In
review,
we
emphasize
how
small
biological
entities,
such
as
viruses,
bacteria,
archaea,
fungi,
protozoans,
microalgae,
well
their
related
structural
compounds
toxins/metabolites/bioactive
molecules,
can
prevent
suppress
or
regulate
malignant
initiation,
progression,
metastasis,
responses
different
therapies.
All
these
fighters
free-living
parasitic
nature
and,
furthermore,
protozoans
components
human
animal
microbiomes.
Recently,
polymorphic
microbiomes
have
been
recognized
new
emerging
hallmark
cancer.
Fortunately,
there
no
limit
development
novel
biomedicine.
Thus,
viral
vector-based
based
on
genetically
engineered
bacteriotherapy,
mycotherapy
anti-cancer
fungal
bioactive
compounds,
use
protozoan
parasite-derived
proteins,
nanoarchaeosomes,
microalgae-based
microrobots
oncology,
promoting
biomimetic
biology-inspired
strategies
maximize
diagnostic
efficiency,
improved
life.
Journal of Multidisciplinary Healthcare,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1493 - 1510
Published: March 1, 2025
Abstract:
This
review
explores
the
multifaceted
roles
and
applications
of
probiotics,
emphasizing
their
significance
in
maintaining
enhancing
host
health
through
microbial
interactions.
It
includes
concept
holobionts
symbiotic
relationships
between
hosts
microbiomes,
illustrating
how
various
microbiota
can
enhance
immunity,
support
growth,
prevent
diseases.
delves
into
customization
probiotics
using
molecular
genomic
techniques,
focusing
Enterococcus,
Bifidobacterium
,
Lactobacillus
species.
Furthermore,
it
discusses
effects
symbiotics
which
aids
survivability
beneficial
probiotics.
The
role
microbes
gut
is
emphasized,
noting
its
impact
on
preventing
diseases
a
stable
community.
potential
therapeutic
value
ability
to
treat
gastrointestinal
diseases,
as
well
strengthen
immune
system
reduce
number
free
radicals
that
are
present
body.
Additionally,
secondary
metabolites
produced
by
bacteria
gut,
such
bacteriocins
exopolysaccharides,
effect
human,
particularly
tract.
concludes
addressing
use
traditional
medicine
novel
applications,
including
treatment
endangered
wildlife
species
human
ailments.
Keywords:
health,
microbiota,
metabolites,
synergistic
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 12, 2025
Background
Mild
intestinal
dysfunction,
linked
to
subtle
yet
significant
health
issues,
can
be
induced
by
lipopolysaccharide
(LPS),
a
Gram-negative
bacterial
component
that
disrupts
gut
function
and
triggers
inflammation.
Akkermansia
muciniphila
has
shown
promise
as
probiotic
for
due
its
roles
in
mucin
degradation
short-chain
fatty
acid
production.
This
study
explores
the
therapeutic
effects
of
on
LPS-induced
mild
dysfunction
mice.
Methods
Thirty-eight
6-week-old
C57BL/6
mice
were
split
into
control
(
n
=
19)
LPS-treated
groups.
received
300
μg/kg/day
LPS
4
weeks,
followed
supplementation
at
41
mg/kg/day
(Akk1)
or
82
(Akk2)
another
weeks.
Gut
microbiota
was
analyzed
via
metagenomic
sequencing,
gene
expression
evaluated
through
transcriptomics.
Results
significantly
altered
microbiota,
reducing
diversity
increasing
pathogenic
genera
like
Lachnoclostridium.
supplementation,
particularly
higher
doses,
partially
restored
beneficial
such
Muribaculum.
Transcriptomics
showed
immune
inflammatory
responses,
while
reduced
these
modulating
pathways
TNF
NF-kappa
B
signaling.
Conclusion
mitigates
restoring
balance
highlighting
potential
agent
health.
