The Outcome of BA.5 Omicron in Transplant Cases: A Retrospective Single-center Study in Jeddah Saudi Arabia

Dr Sulaiman Al Habib Medical Journal, Journal Year: 2025, Volume and Issue: 7(1), P. 22 - 29

Published: Jan. 1, 2025

Abstract Introduction: The global incidence of coronavirus disease 2019 (COVID-19) has increased significantly due to the Omicron wave. interaction between host factors, including immune status and vaccination history, along with circulating SARS-CoV-2 variant, collectively influences clinical outcomes following exposure COVID-19. Material Methods: This retrospective study examined patients infected COVID-19 during BA.5 wave at King Faisal Specialist Hospital Research Center in Jeddah, Saudi Arabia. Results: A total 25 were included study, comprising 12 (48%) males 13 (52%) females. Despite most having multiple underlying chronic medical conditions a mean age 48 years, isolated home. Three (12%) asymptomatic, 17 (68%) experienced mild symptoms, 1 (4%) developed pneumonia not requiring oxygen, 2 (8%) required low-flow invasive ventilation. 22 (88%) had received vaccinations, 6 (24%) receiving doses, 3 4 doses. Mortality was reported patients; however, no deaths observed among renal transplant recipient variant. Conclusion: Our findings suggest that who underwent transplantation variant lower mortality rates shorter ICU stays compared those BA.1 or BA.2 outcome may be attributed higher proportion three doses vaccine.

Language: Английский

SARS-CoV-2 Alchemy: Understanding the dynamics of age, vaccination, and geography in the evolution of SARS-CoV-2 in India

PLoS neglected tropical diseases, Journal Year: 2025, Volume and Issue: 19(3), P. e0012918 - e0012918

Published: March 10, 2025

Background COVID-19 pandemic had unprecedented global impact on health and society, highlighting the need for a detailed understanding of SARS-CoV-2 evolution in response to host environmental factors. This study investigates via mutation dynamics, focusing distinct age cohorts, geographical location, vaccination status within Indian population, one nations most affected by COVID-19. Methodology Comprehensive dataset, across diverse time points during Alpha, Delta, Omicron variant waves, captured essential phases pandemic’s footprint India. By leveraging genomic data from Global Initiative Sharing Avian Influenza Data (GISAID), we examined substitution landscape three demographic segments: children (1–17 years), working-age adults (18–64 elderly individuals (65+ years). A balanced dataset 69,975 samples was used study, comprising 23,325 each group. design ensured high statistical power, as confirmed power analysis. We employed bioinformatics analyses, explore genetic diversity patterns frequencies groups. Principal findings The group exhibited notably frequency unique substitutions, suggesting that immune pressures highly interactive populations may accelerate viral adaptation. Geographic analysis emphasizes notable regional variation rates, potentially driven population density local transmission while regions with more homogeneous strain circulation show relatively lower rates. also revealed significant surge substitutions all groups period, rates remaining elevated even after widespread vaccination, compared pre-vaccination levels. trend supports virus’s adaptive heightened observed through increased prevalence important genome like ORF1ab Spike, contributing escape transmissibility. Conclusion Our affirm importance continuous surveillance evolution, particularly countries research provides insights anticipating future outbreaks refining preparedness strategies, thus enhancing our capacity proactive responses.

Language: Английский

Comparative Atlas of SARS-CoV-2 Substitution Mutations: A Focus on Iranian Strains Amidst Global Trends

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1331 - 1331

Published: Aug. 20, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new emerging that caused disease 2019 (COVID-19). Whole-genome tracking of SARS-CoV-2 enhanced our understanding the mechanism disease, control, and prevention COVID-19.

Language: Английский