Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

The extensive use of antibiotics in animal husbandry, either for therapeutic purposes or as growth promoters, has raised significant concerns about their effects on poultry. However, when are used agents, impact the gut microbiota poultry remains unknown. This study aimed to address this gap by simulating application six frequently (lincomycin hydrochloride, gentamicin sulfate, florfenicol injection, benzylpenicillin potassium, ceftiofur sodium, and enrofloxacin infection) investigated composition structure microbiota. Single-molecule real-time 16S rRNA sequencing was performed analyze fecal samples collected from chickens treated with each antibiotic assess exposure community diversity dominant microbial species. Although results demonstrated that reduced disrupted stability, impacts different differed considerably, specifically number ASVs. Notably, bacterial phyla— Pseudomonadota Bacillota— largely consistent across exposures, except 11 days after sulfate exposure. Moreover, third-category pathogens were identified samples, namely, Shigella boydii , Escherichia coli flexneri Salmonella enterica Corynebacterium bovis Proteus mirabilis . Of these, three strains potential novel pathogenic bacteria. These findings demonstrate critical importance rational husbandry. provides a scientific basis improving current treatment prevention diseases, advancing standardization precision usage.

Language: Английский