Characteristics of Intestinal Microbiota and Host Gene Regulation in Coilia nasus Responding to Stress DOI Creative Commons
Jun Gao,

Haojun Zhu,

Jiancao Gao

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(6), P. 626 - 626

Published: May 23, 2025

Transport stress in aquaculture poses significant challenges to fish health by inducing oxidative and intestinal damage. This study investigated the effects of transport on microbiota, host gene regulation, metabolic responses Coilia nasus. The were subjected simulated conditions, followed an analysis their antioxidant capacity, inflammatory factors, transcriptome sequencing, metagenomic profiling, metabolomic assays. results revealed that significantly suppressed enzyme activities (e.g., catalase, superoxide dismutase, glutathione peroxidase) elevated damage (malondialdehyde, lipid peroxidation) alongside upregulating pro-inflammatory cytokines. transcriptomic identified differentially expressed genes enriched metabolism ferroptosis pathways, with increased peroxidation iron overload activating ferroptosis. data showed altered gut microbiota composition, including Aeromonas reduced beneficial metabolites propionic acid, bile acids). Correlation analyses linked microbial shifts metabolite changes barrier dysfunction. These findings demonstrate disrupts redox balance, induces ferroptosis, reshapes collectively compromising integrity C.

Language: Английский

The Significance of Probiotics in Aquaculture: A Review of Research Trend and Latest Scientific Findings DOI Creative Commons

Elshafia Ali Hamid Mohammed,

Abdelhakam Esmaeil Mohamed Ahmed, Béla Kovács

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 242 - 242

Published: Feb. 27, 2025

Millions of people around the world rely on aquaculture as a major source food. In recent few years, probiotics have gained considerable attention an alternative agent to antibiotics. They been shown play important role in improving species through different mechanisms, mainly disease management, their growth performance, and water quality. Consequently, this review aimed identify key areas research global literature about influence based selected keywords “aquaculture” AND “probiotics” “growth performance” “disease resistance” (APGD). The meta-data published were extracted from Web Science (WoS) database 23 December 2024, then co-authors, countries, analyzed visualized using VOSviewer (v. 1.6.20). search found remarkable number documents, which included 175 APGD documents. results bibliometric analysis reveal substantial increase publication documents 2019 2024. Asia, particularly China (32.3% documents), has emerged leader publications, followed by Iran (8.67%), India (8.01%), Malaysia (7.5%), Spain respectively. Keyword revealed prevalence resistance (length = 1793), (1348), (1169), performance (913) most impactful WoS database. This could indicate that focused relationships. addition, extensive showed demonstrated efficacy feed utilization efficiency, prevention, quality management various under systems when used or additives for 30–90 days. It can be concluded Asia is lead continent research, with significant last 5 years. Probiotics played aquatic species. aims provide valuable insight into use highlights need further fully understand benefits mechanisms action.

Language: Английский

Citations

3
Probiotic Supplementation Improves Lipid Metabolism Disorders and Immune Suppression Induced by High-Fat Diets in Coilia nasus Liver DOI Creative Commons
Jun Gao,

Qi Mang,

Yi Sun

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 381 - 381

Published: April 7, 2025

High-fat diets (HFDs) usually trigger disruptions in lipid metabolic processes and immune suppression fish. As an eco-friendly potent additive, the inclusion of probiotics fish ameliorates dysregulations metabolism, mitigates oxidative stress, reduces inflammatory reactions triggered by HFDs. However, little current research has focused on improvement hazards HFDs probiotics. Therefore, we employed 4-dimensional data-independent (4D-DIA) proteomic analysis to investigate mechanism protective impact against HFD-induced hepatic injury Coilia nasus between HFD group probiotic supplementation (PHFD) group. Additionally, accumulation antioxidant indicators liver were also measured via Oil Red O staining activity detection. Administration markedly attenuated concentrations triglycerides (TG), cholesterol (CHO), low-density lipoprotein (LDL-C) C. subjected Furthermore, it significantly upregulated expression differentially expressed proteins (DEPs) implicated metabolism fatty acid oxidation, while concurrently downregulating DEPs associated with synthesis. reduced aspartate aminotransferase (AST), alanine (ALT), malondialdehyde (MDA) levels induced It activities catalase (CAT) superoxide dismutase (SOD). Probiotic related antioxidants, responses autophagy. These findings suggested that ameliorated enhancing concomitantly synthesis pathways. protected defenses suppressing inflammation nasus.

Language: Английский

Citations

0
Microbial-algal symbiotic system drives reconstruction of nitrogen, phosphorus, and methane cycles for purification of pollutants in aquaculture water DOI
Jun Gao,

Qi Mang,

Quanjie Li

et al.

Bioresource Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132531 - 132531

Published: April 1, 2025

Language: Английский

Citations

0
Characteristics of Intestinal Microbiota and Host Gene Regulation in Coilia nasus Responding to Stress DOI Creative Commons
Jun Gao,

Haojun Zhu,

Jiancao Gao

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(6), P. 626 - 626

Published: May 23, 2025

Transport stress in aquaculture poses significant challenges to fish health by inducing oxidative and intestinal damage. This study investigated the effects of transport on microbiota, host gene regulation, metabolic responses Coilia nasus. The were subjected simulated conditions, followed an analysis their antioxidant capacity, inflammatory factors, transcriptome sequencing, metagenomic profiling, metabolomic assays. results revealed that significantly suppressed enzyme activities (e.g., catalase, superoxide dismutase, glutathione peroxidase) elevated damage (malondialdehyde, lipid peroxidation) alongside upregulating pro-inflammatory cytokines. transcriptomic identified differentially expressed genes enriched metabolism ferroptosis pathways, with increased peroxidation iron overload activating ferroptosis. data showed altered gut microbiota composition, including Aeromonas reduced beneficial metabolites propionic acid, bile acids). Correlation analyses linked microbial shifts metabolite changes barrier dysfunction. These findings demonstrate disrupts redox balance, induces ferroptosis, reshapes collectively compromising integrity C.

Language: Английский

Citations

0