Microbial Fermentation and Therapeutic Potential of p-Cymene: Insights into Biosynthesis and Antimicrobial Bioactivity DOI Creative Commons
Yeonhee Pyo,

Yeon Ja Jung

Fermentation, Journal Year: 2024, Volume and Issue: 10(9), P. 488 - 488

Published: Sept. 19, 2024

p-Cymene (p-C) [1-methyl-4-(1-methylethyl)-benzene] is a monoterpene found in variety of plants and has several biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer properties. This paper explores the microbial fermentation pathways involved biosynthesis p-C, with an emphasis on its potential as therapeutic agent. Through biochemical processes, p-C can be produced using renewable precursors such limonene 1,8-cineole. Recent advances technology have enhanced efficiency production, highlighting role various industries. Additionally, this reviews antimicrobial bioactivity focusing ability to inhibit pathogens modulate immune responses. The integration methods offers sustainable approach producing for applications perfume, cosmetics, food, pharmaceutical sectors. Understanding these biosynthetic crucial advancing use bio-based chemical potential. In particular, inhibits expression cytokine signal 3 intestinal inflammation modulates antioxidant immunomodulatory systems protect barrier cells maintain mucus layer.

Language: Английский

Review on recent advances in supported metal catalysts for synthesis of high energy density fuels DOI
Li Tian, Dandan Jia,

Shenglan Zhou

et al.

Fuel, Journal Year: 2024, Volume and Issue: 373, P. 132329 - 132329

Published: July 1, 2024

Language: Английский

Citations

8
Research progress in the synthesis of high-energy-density fuels DOI

Lifu Xiong,

C.-Y. Wu,

M.L. Li

et al.

Fuel Processing Technology, Journal Year: 2025, Volume and Issue: 271, P. 108200 - 108200

Published: March 10, 2025

Language: Английский

Citations

0
Engineering Escherichia coli for Perillyl Alcohol Production with Reduced Endogenous Dehydrogenation DOI

Yan‐Peng Hao,

Meiling Liu, Eric Fordjour

et al.

ACS Synthetic Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 1594 - 1605

Published: April 25, 2025

Perillyl alcohol is a widely utilized antitumor agent in cancer therapy. Due to the limitations associated with chemical synthesis and plant extraction methods, bioengineering microorganisms for production of perillyl its precursor limonene offers more scalable industrially compatible approach. In this study, we present design an Escherichia coli cell factory capable de novo from glucose. A comprehensive systems engineering approach was employed increase availability, enhance electron transfer efficiency, reduce byproduct formation, resulting efficient production. Specifically, ribosome-binding site optimization increased enzyme expression improved 417.04 mg/L. Additionally, overexpression cytochrome P450 transport proteins, knockdown endogenous ethanol dehydrogenase prevent product loss, implementation two-phase fermentation led 309.1 mg/L shake flask cultures, which marks highest titer reported systems. This illustrates critical role reducing aldehyde formation enhancing feasibility coli-based production, providing foundation economical large-scale via microbial bioprocessing.

Language: Английский

Citations

0
Microbial Fermentation and Therapeutic Potential of p-Cymene: Insights into Biosynthesis and Antimicrobial Bioactivity DOI Creative Commons
Yeonhee Pyo,

Yeon Ja Jung

Fermentation, Journal Year: 2024, Volume and Issue: 10(9), P. 488 - 488

Published: Sept. 19, 2024

p-Cymene (p-C) [1-methyl-4-(1-methylethyl)-benzene] is a monoterpene found in variety of plants and has several biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer properties. This paper explores the microbial fermentation pathways involved biosynthesis p-C, with an emphasis on its potential as therapeutic agent. Through biochemical processes, p-C can be produced using renewable precursors such limonene 1,8-cineole. Recent advances technology have enhanced efficiency production, highlighting role various industries. Additionally, this reviews antimicrobial bioactivity focusing ability to inhibit pathogens modulate immune responses. The integration methods offers sustainable approach producing for applications perfume, cosmetics, food, pharmaceutical sectors. Understanding these biosynthetic crucial advancing use bio-based chemical potential. In particular, inhibits expression cytokine signal 3 intestinal inflammation modulates antioxidant immunomodulatory systems protect barrier cells maintain mucus layer.

Language: Английский

Citations

1