Bibliometric analysis of neutrophil extracellular traps induced by protozoan and helminth parasites (2008–2024)

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Introduction Parasitic diseases pose a significant global public health challenge, affecting billions of people and causing substantial economic losses in livestock poultry. In the fight against these infections, neutrophils play crucial role, employing various strategies, including release neutrophil extracellular traps (NETs). Recent studies have made progress understanding NETs triggered by protozoa helminths. However, comprehensive bibliometric analysis that compiles findings identifies research hotspots trends this field is still lacking. Methods We utilized Web Science Core Collection Scopus databases to retrieve original articles on induced After screening, data was transferred visualization tools VOSviewer, Biblioshiny, CiteSpace for analysis. Results Our study included 159 published 69 journals, involving 909 authors from 270 institutions across 41 countries. Germany Brazil most contributions parasites, accounting 45 32 publications, 1,495 1,342 citations, respectively. Carlos Hermosilla Anja Taubert (Justus Liebig University Giessen, Germany), Elvira Saraiva (Federal Rio de Janeiro, Brazil), are leaders field, both terms publication output citations. Frontiers Immunology has consistently significantly impacted an article Proceedings National Academy Sciences United States America providing first direct evidence response parasite far cited. Current focuses malaria, Toxoplasma gondii , Besnoitia besnoiti nematodes, mechanisms production their effects parasites host cells. Emerging include therapeutic targeting comparative different species. Conclusion This offers overview visual highlighting key areas future research.

Language: Английский

Neutrophils is triggered against Paragonimus skrjabini infection while Th2 cell response was attenuated

Authorea (Authorea), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

To study on the proteome and to investigate immune response mechanisms in P. skrjabini infection. Serum samples were randomly collected from patients with infection healthy individuals Guizhou Province. ITRAQ (Isobaric Tags for Relative Absolute Quantitation) assays utilized analysis of protein catalogs serum samples. Bioinformatics differed proteins was performed. River crabs sampled patients’ habitats, Paragonimus metacercariae isolated subsequent rat experimental White blood cells at 42 days post-infection, changes expression IL-4 assessed. In result, a total 50 identified. Typically, increased neutrophil defensin 3, S100-A9 (S100A9) amyloid A-1 (SAA1) found. S100A9 SAA1 involved main network but DEFA3 not. The interaction networks constituted core Apolipoproteins family interactions fibrinogen fibrinolytic system. Through infections rats, Th2 cytokines remains unaltered. conclusion, neutrophils may play pivotal role elimination parasites, whereas host cell is suppressed eliminating worms.

Language: Английский